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Article

Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study

  • Authors:
    • Susumu Matsukuma
    • Ayano Matsunaga
    • Sho Ogata
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
  • Article Number: 449
    |
    Published online on: October 3, 2024
       https://doi.org/10.3892/etm.2024.12739
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Abstract

To describe histopathological features of rhinoplasty‑related implanted cartilages, 83 cartilages surgically removed from 42 patients (2 men and 40 women) with a median age of 28.0 years (range, 21‑47 years) following correction/revision rhinoplasty were examined. These cartilages included 16 autologous costal cartilages (ACCs), 14 irradiated homologous costal cartilages (IHCCs), 24 autologous nasal cartilages (ANCs), 2 irradiated homologous nasal cartilages (IHNCs), 14 autologous ear cartilages (ECs) and 13 combined cartilaginous grafts. The median chondrocytic viability in ACCs (35.9%) was higher than that of IHCCs (0.0%) and ECs (21.4%) (both, P<0.001), and showed no significant differences compared with the viability in ANCs (41.3%) (P=0.455). The median organized rate of chondroid matrix in ACCs, IHCCs, ANCs and ECs was 2.5, 1.4, 0.9 and 2.0%, respectively, and there were no significant differences among them (P=0.909). The present study revealed not only enlarged chondrocytic lacunae, chondrocytic cloning and binucleated/trinucleated chondrocytes, but also a possible transition between chondrocytes and fibroblasts in 6 ACCs, 3 ANCs and 1 EC, lipomembranous fat necrosis (LFN)‑like bodies in 15 ACCs, 14 IHCCs, 3 ANCs and 5 ECs, and chondrocytic vacuolar changes in 15 ACCs, 22 ANCs, 2 IHNCs and 16 ECs. A histological transition between LFN‑like bodies and chondrocytic vacuoles was focally observed in 2 ACCs and 1 ANC. The present findings suggested that the stability of implanted cartilage did not depend on chondrocytic viability only. Viable chondrocytes preserve implanted chondroid matrix, but also may, in part, induce organization through their transformation into fibroblasts. LFN‑like bodies are considered to be an underrecognized form of vacuolar change‑related chondrocytic necrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Matsukuma S, Matsunaga A and Ogata S: Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study. Exp Ther Med 28: 449, 2024.
APA
Matsukuma, S., Matsunaga, A., & Ogata, S. (2024). Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study. Experimental and Therapeutic Medicine, 28, 449. https://doi.org/10.3892/etm.2024.12739
MLA
Matsukuma, S., Matsunaga, A., Ogata, S."Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study". Experimental and Therapeutic Medicine 28.6 (2024): 449.
Chicago
Matsukuma, S., Matsunaga, A., Ogata, S."Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study". Experimental and Therapeutic Medicine 28, no. 6 (2024): 449. https://doi.org/10.3892/etm.2024.12739
Copy and paste a formatted citation
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Spandidos Publications style
Matsukuma S, Matsunaga A and Ogata S: Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study. Exp Ther Med 28: 449, 2024.
APA
Matsukuma, S., Matsunaga, A., & Ogata, S. (2024). Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study. Experimental and Therapeutic Medicine, 28, 449. https://doi.org/10.3892/etm.2024.12739
MLA
Matsukuma, S., Matsunaga, A., Ogata, S."Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study". Experimental and Therapeutic Medicine 28.6 (2024): 449.
Chicago
Matsukuma, S., Matsunaga, A., Ogata, S."Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study". Experimental and Therapeutic Medicine 28, no. 6 (2024): 449. https://doi.org/10.3892/etm.2024.12739
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