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Review Open Access

Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review)

  • Authors:
    • Wan-Yun Lin
    • Yu-Lei Dong
    • Yang Lin
    • Diwas Sunchuri
    • Zhu-Ling Guo
  • View Affiliations / Copyright

    Affiliations: Health Management Center, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China, School of Dentistry, Hainan Medical University, Haikou, Hainan 570100, P.R. China, School of International Education, Hainan Medical University, Haikou, Hainan 570100, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
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    Published online on: October 23, 2024
       https://doi.org/10.3892/etm.2024.12752
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Abstract

G protein‑coupled receptor 124 (GPR124) has a key role in regulating the proliferation and differentiation of endothelial cells, activating inflammatory bodies and promoting angiogenesis and other processes, thus affecting various pathological and physiological processes in the body. GPR124 is vital for promoting the development of the nervous system and maintaining the stability of the blood‑brain barrier, and is also associated with cardiovascular and cerebrovascular diseases and cancer. This article will elaborate on the biological information regarding GPR124 published in recent years and its possible related signaling pathways in the field of diseases and provide a reference for further revealing the role of GPR124 in the occurrence and development of diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Lin W, Dong Y, Lin Y, Sunchuri D and Guo Z: Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review). Exp Ther Med 29: 2, 2025.
APA
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., & Guo, Z. (2025). Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review). Experimental and Therapeutic Medicine, 29, 2. https://doi.org/10.3892/etm.2024.12752
MLA
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., Guo, Z."Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review)". Experimental and Therapeutic Medicine 29.1 (2025): 2.
Chicago
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., Guo, Z."Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review)". Experimental and Therapeutic Medicine 29, no. 1 (2025): 2. https://doi.org/10.3892/etm.2024.12752
Copy and paste a formatted citation
x
Spandidos Publications style
Lin W, Dong Y, Lin Y, Sunchuri D and Guo Z: Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review). Exp Ther Med 29: 2, 2025.
APA
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., & Guo, Z. (2025). Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review). Experimental and Therapeutic Medicine, 29, 2. https://doi.org/10.3892/etm.2024.12752
MLA
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., Guo, Z."Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review)". Experimental and Therapeutic Medicine 29.1 (2025): 2.
Chicago
Lin, W., Dong, Y., Lin, Y., Sunchuri, D., Guo, Z."Potential role of G protein‑coupled receptor 124 in cardiovascular and cerebrovascular disease (Review)". Experimental and Therapeutic Medicine 29, no. 1 (2025): 2. https://doi.org/10.3892/etm.2024.12752
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