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Case Report Open Access

Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review

  • Authors:
    • Zhipeng Shen
    • Masashi Mizumoto
    • Yoshiko Oshiro
    • Yonglong Jin
    • Jie Wang
    • Shuyan Zhang
    • Chao Liu
    • Zishen Wang
    • Wei Wang
    • Yinuo Li
    • Weiwei Wang
    • Jun Zhao
    • Shosei Qingshui Shimizu Xiangxing
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki 305‑8576, Japan, Department of Radiation Oncology, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki 305‑8558, Japan, Department of Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Radiotherapy Physics and Technology, Hebei Yizhou Cancer Hospital, Zhuozhou, Hebei 072750, P.R. China, Department of Pediatric Radiation Therapy Center/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, Hebei 072750, P.R. China, Department of Radiology, Hebei Yizhou Cancer Hospital, Zhuozhou, Hebei 072750, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 14
    |
    Published online on: November 18, 2024
       https://doi.org/10.3892/etm.2024.12763
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Abstract

Intraosseous hemangiomas are rare, benign tumors, predominantly affecting the vertebrae, calvarium and other bones. These lesions, although slow progressing, can lead to complications such as visual disturbances and structural deformities. Standard management includes surgical interventions and more recently, advanced radiation therapies such as proton beam therapy (PBT) have been explored due to their precision and minimized damage to surrounding tissues. The current study presents a compelling case of a 10‑year‑old female patent diagnosed with a giant calvarial hemangioma located at the cranio‑orbital junction. Although it was initially managed with surgery and chemotherapy, the tumor recurred. Given the recurrence and proximity to critical structures, PBT was employed. The treatment was administered over 28 fractions, with a total dose of 50.4 Gy. The patient exhibited good tolerance to the treatment, experiencing only minor acute side effects such as hair loss and skin pigmentation. At 14 months post‑PBT, a marked reduction in tumor size was revealed with no further progression, indicating effective local control of the hemangioma. In addition, the side effects had improved markedly, highlighting the long‑term benefits and efficacy of PBT in managing this challenging case. This is the first case in which PBT has been used to manage a calvarial hemangioma in children to the best of the authors' knowledge. The current case highlights the potential of PBT in treating complex intraosseous hemangiomas where conventional therapies are ineffective. Further research into long‑term outcomes is necessary to establish PBT as a crucial approach for similar cases.
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1 

Yao K, Tang F, Min L, Zhou Y and Tu C: Multifocal intraosseous hemangioma: A case report. Medicine (Baltimore). 98(e14001)2019.PubMed/NCBI View Article : Google Scholar

2 

Choi JS, Bae YC, Kang GB and Choi KU: Intraosseous hemangioma of the orbit. Arch Craniofac Surg. 19:68–71. 2018.PubMed/NCBI View Article : Google Scholar

3 

Akhter AS, El Tecle N, Alexopoulos G, Espinoza G and Coppens J: Intraosseous orbital cavernous hemangioma with frontal extension and dural involvement. Cureus. 11(e4823)2019.PubMed/NCBI View Article : Google Scholar

4 

Ramkumar S: Epithelioid Haemangioma of Bone: A case series and comprehensive literature review reappraising the diagnostic classification of all epithelioid vascular neoplasms of bone. Cureus. 13(e15371)2021.PubMed/NCBI View Article : Google Scholar

5 

Powers DB, Fisher E and Erdmann D: Zygomatic intraosseous hemangioma: Case report and literature review. Craniomaxillofac Trauma Reconstr. 10:1–10. 2017.PubMed/NCBI View Article : Google Scholar

6 

Almeida JA, Gellen PVB, Hiramatsu DM, Santos MAD, Bitencourt L, Marceliano EFV, Galhardi MPW, Marceliano-Alves MF and Marques EF: Cavernous Hemangioma in the Orbital Cavity: Case Report. Eur J Dent. 16:230–233. 2022.PubMed/NCBI View Article : Google Scholar

7 

Ademi Abdyli R, Abdyli Y, Perjuci F, Gashi A, Agani Z and Ahmedi J: Sclerotherapy of Intraoral Superficial Hemangioma. Case Rep Dent. 2016(4320102)2016.PubMed/NCBI View Article : Google Scholar

8 

Sharma S, Kamal R and Rathi AK: Vertebral hemangioma- the current radiation therapy perspective. Rep Pract Oncol Radiother. 28:93–101. 2023.PubMed/NCBI View Article : Google Scholar

9 

Shimizu S, Mizumoto M, Okumura T, Li Y, Baba K, Murakami M, Ishida T, Nakamura M, Hiroshima Y, Iizumi T, et al: Proton beam therapy for a giant hepatic hemangioma: A case report and literature review. Clin Transl Radiat Oncol. 27:152–156. 2021.PubMed/NCBI View Article : Google Scholar

10 

Park S, Yoon SM, Lee S, Park JH, Song SY, Lee SW, Ahn SD, Kim JH and Choi EK: Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus. Radiat Oncol J. 35:268–273. 2017.PubMed/NCBI View Article : Google Scholar

11 

Ooi KH and Low SW: Fractionated External-beam Radiation Therapy For Incompletely Resected Intracranial Extra-axial Cavernous Haemangioma: A Case Report. Cureus. 10(e2285)2018.PubMed/NCBI View Article : Google Scholar

12 

Matsuda M, Mizumoto M, Kohzuki H, Sugii N, Sakurai H and Ishikawa E: High-dose proton beam therapy versus conventional fractionated radiation therapy for newly diagnosed glioblastoma: A propensity score matching analysis. Radiat Oncol. 18(38)2023.PubMed/NCBI View Article : Google Scholar

13 

Senirkentli GB, Ekinci F, Bostanci E, Güzel MS, Dağli Ö, Karim AM and Mishra A: Proton Therapy for Mandibula Plate Phantom. Healthcare (Basel). 9(167)2021.PubMed/NCBI View Article : Google Scholar

14 

Nakamura M, Mizumoto M, Saito T, Shimizu S, Li Y, Oshiro Y, Inaba M, Hosaka S, Fukushima H, Suzuki R, et al: A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024. Front Oncol. 14(1380716)2024.PubMed/NCBI View Article : Google Scholar

15 

Li Y, Mizumoto M, Oshiro Y, Nitta H, Saito T, Iizumi T, Kawano C, Yamaki Y, Fukushima H, Hosaka S, et al: A retrospective study of renal growth changes after proton beam therapy for pediatric malignant tumor. Curr Oncol. 30:1560–1570. 2023.PubMed/NCBI View Article : Google Scholar

16 

Li Y, Mizumoto M, Nitta H, Fukushima H, Suzuki R, Hosaka S, Yamaki Y, Murakami M, Baba K, Nakamura M, et al: Late Changes in Renal Volume and Function after Proton Beam Therapy in Pediatric and Adult Patients: Children Show Significant Renal Atrophy but Deterioration of Renal Function Is Minimal in the Long-Term in Both Groups. Cancers (Basel). 16(1634)2024.PubMed/NCBI View Article : Google Scholar

17 

Jin Y, Shimizu S, Li Y, Yao Y, Liu X, Si H, Sakurai H and Xiao W: Proton therapy (PT) combined with concurrent chemotherapy for locally advanced non-small cell lung cancer with negative driver genes. Radiat Oncol. 18(189)2023.PubMed/NCBI View Article : Google Scholar

18 

Liu H, Chang X, Shang H, Li F, Zhou H and Xue X: Diffuse cavernous hemangioma of the skull misdiagnosed as skull metastasis in breast cancer patient: One case report and literature review. BMC Cancer. 19(172)2019.PubMed/NCBI View Article : Google Scholar

19 

Fujii T, Zen Y, Sato Y, Sasaki M, Enomae M, Minato H, Masuda S, Uehara T, Katsuyama T and Nakanuma Y: Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol. 21:125–130. 2008.PubMed/NCBI View Article : Google Scholar

20 

Majchrzak K, Kaspera W, Szymaś J, Bobek-Billewicz B, Hebda A and Majchrzak H: Markers of angiogenesis (CD31, CD34, rCBV) and their prognostic value in low-grade gliomas. Neurol Neurochir Pol. 47:325–331. 2013.PubMed/NCBI View Article : Google Scholar

21 

Mehndiratta M, Nayak R, Garg H, Kumar M and Pandey S: Appraisal of Kernig's and Brudzinski's sign in meningitis. Ann Indian Acad Neurol. 15:287–288. 2012.PubMed/NCBI View Article : Google Scholar

22 

Niitsu H, Mizumoto M, Li Y, Nakamura M, Ishida T, Iizumi T, Saito T, Numajiri H, Makishima H, Nakai K, et al: Tumor response on diagnostic imaging after proton beam therapy for hepatocellular carcinoma. Cancers (Basel). 16(357)2024.PubMed/NCBI View Article : Google Scholar

23 

Jorge MIS, Brinkmann JCB, Corchón AG and Ocaña RA: Diagnostic challenge and management of intraosseous mandibular hemangiomas: A case report and literature review. J Korean Assoc Oral Maxillofac Surg. 47:321–326. 2021.PubMed/NCBI View Article : Google Scholar

24 

Yang Y, Guan J, Ma W, Li Y, Xing B, Ren Z, Su C and Wang R: Primary Intraosseous Cavernous Hemangioma in the Skull. Medicine (Baltimore). 95(e3069)2016.PubMed/NCBI View Article : Google Scholar

25 

Kirmani AR, Sarmast AH and Bhat AR: A unique case of calvarial hemangioma. Surg Neurol Int. 7 (Suppl 14):S398–S401. 2016.PubMed/NCBI View Article : Google Scholar

26 

Myadam S, Kishan V, Deepa A, Shri Puja K and Divya Rani K: Intraosseous hemangioma of the zygomatic bone: A rare site for hemangioma. Med J Armed Forces India. 72:85–87. 2015.PubMed/NCBI View Article : Google Scholar

27 

Ilyas M, Shah SA, Gojwari T, Rafiq S, Ellahi I and Ganaie KH: Classic imaging features of calvarial hemangioma-a case report. The Egyptian J Radiol Nucl Med. 49:663–665. 2018.

28 

Geng P, Sun X and Liu J: Adopting quaternion wavelet transform to fuse multi-modal medical images. J Med Biol Eng. 37:230–239. 2017.PubMed/NCBI View Article : Google Scholar

29 

Leong S, Kok HK, Delaney H, Feeney J, Lyburn I, Munk P and Torreggiani W: The Radiologic Diagnosis and Treatment of Typical and Atypical Bone Hemangiomas: Current Status. Can Assoc Radiol J. 67:2–11. 2016.PubMed/NCBI View Article : Google Scholar

30 

Dong WK and Chang HC: A Case of Calvarial Hemangioma in Cranioplasty Site. J Korean Neurosurg Soc. 46:484–487. 2009.PubMed/NCBI View Article : Google Scholar

31 

Tomioka Y, Kondo K, Numahata T, Moriwaki Y and Okazaki M: Endoscopic open rhinoplasty enables a cosmetic approach for a rare case of intraosseous cavernous hemangioma in the nasal bone. Auris Nasus Larynx. 47:1064–1069. 2020.PubMed/NCBI View Article : Google Scholar

32 

Sary A, Yavuzer R, Latfoglu O and Çelebi MC: Intraosseous Zygomatic Hemangioma. Ann Plast Surg. 46:659–660. 2001.PubMed/NCBI View Article : Google Scholar

33 

Lee CC, Sheehan JP, Kano H, Akpinar B, Martinez-Alvarez R, Martinez-Moreno N, Guo WY, Lunsford LD and Liu KD: Gamma Knife radiosurgery for hemangioma of the cavernous sinus. J Neurosurg. 126:1498–1505. 2017.PubMed/NCBI View Article : Google Scholar

34 

Gaspar L, Mascarenhas F, da Costa MS, Dias JS, Afonso JG and Silvestre ME: Radiation therapy in the unresectable cavernous hemangioma of the liver. Radiother Oncol. 29:45–50. 1993.PubMed/NCBI View Article : Google Scholar

35 

Peters S, Frisch S, Stock A, Merta J, Bäumer C, Blasé C, Schuermann E, Tippelt S, Bison B, Frühwald M, et al: Proton beam therapy for pediatric tumors of the central nervous system-experiences of clinical outcome and feasibility from the KiProReg Study. Cancers (Basel). 14(5863)2022.PubMed/NCBI View Article : Google Scholar

36 

Spiotto MT, McGovern SL, Gunn GB, Grosshans D, McAleer MF, Frank SJ and Paulino AC: Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers. Int J Part Ther. 8:155–167. 2021.PubMed/NCBI View Article : Google Scholar

37 

Takizawa D, Mizumoto M, Yamamoto T, Oshiro Y, Fukushima H, Fukushima T, Terunuma T, Okumura T, Tsuboi K and Sakurai H: A comparative study of dose distribution of PBT, 3D-CRT and IMRT for pediatric brain tumors. Radiat Oncol. 12(40)2017.PubMed/NCBI View Article : Google Scholar

38 

Gross JP, Powell S, Zelko F, Hartsell W, Goldman S, Fangusaro J, Lulla RR, Smiley NP, Chang JH and Gondi V: Improved neuropsychological outcomes following proton therapy relative to X-ray therapy for pediatric brain tumor patients. Neuro Oncol. 21:934–943. 2019.PubMed/NCBI View Article : Google Scholar

39 

Dennis ER, Bussière MR, Niemierko A, Lu MW, Fullerton BC, Loeffler JS and Shih HA: A comparison of critical structure dose and toxicity risks in patients with low grade gliomas treated with IMRT versus proton radiation therapy. Technol Cancer Res Treat. 12:1–9. 2013.PubMed/NCBI View Article : Google Scholar

40 

Sato H, Mizumoto M, Okumura T, Sakurai H, Sakamoto N, Akutsu H, Ishikawa E and Tsuboi K: Long-term outcomes of patients with unresectable benign meningioma treated with proton beam therapy. J Radiat Res. 62:427–437. 2021.PubMed/NCBI View Article : Google Scholar

41 

Kaulfers T, Lattery G, Cheng C, Zhao X, Selvaraj B, Wu H, Chhabra AM, Choi JI, Lin H, Simone CB II, et al: Pencil beam scanning proton bragg peak conformal FLASH in prostate cancer stereotactic body radiotherapy. Cancers (Basel). 16(798)2024.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shen Z, Mizumoto M, Oshiro Y, Jin Y, Wang J, Zhang S, Liu C, Wang Z, Wang W, Li Y, Li Y, et al: Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review. Exp Ther Med 29: 14, 2025.
APA
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S. ... Shimizu Xiangxing, S. (2025). Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review. Experimental and Therapeutic Medicine, 29, 14. https://doi.org/10.3892/etm.2024.12763
MLA
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Zhao, J., Shimizu Xiangxing, S."Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review". Experimental and Therapeutic Medicine 29.1 (2025): 14.
Chicago
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Zhao, J., Shimizu Xiangxing, S."Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review". Experimental and Therapeutic Medicine 29, no. 1 (2025): 14. https://doi.org/10.3892/etm.2024.12763
Copy and paste a formatted citation
x
Spandidos Publications style
Shen Z, Mizumoto M, Oshiro Y, Jin Y, Wang J, Zhang S, Liu C, Wang Z, Wang W, Li Y, Li Y, et al: Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review. Exp Ther Med 29: 14, 2025.
APA
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S. ... Shimizu Xiangxing, S. (2025). Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review. Experimental and Therapeutic Medicine, 29, 14. https://doi.org/10.3892/etm.2024.12763
MLA
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Zhao, J., Shimizu Xiangxing, S."Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review". Experimental and Therapeutic Medicine 29.1 (2025): 14.
Chicago
Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Zhao, J., Shimizu Xiangxing, S."Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review". Experimental and Therapeutic Medicine 29, no. 1 (2025): 14. https://doi.org/10.3892/etm.2024.12763
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