Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2025 Volume 29 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 29 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma

  • Authors:
    • Jiaqi Fu
    • Xingjun Han
    • Wei Gao
    • Manya Yu
    • Xing Cui
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China, Department of Preventive Treating Disease Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China, Laboratory Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China, Department of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China, Department of Oncology and Hematology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
    |
    Published online on: November 18, 2024
       https://doi.org/10.3892/etm.2024.12768
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

N1‑methyladenosine (m1A), a methylation of RNA, is gaining attention for its role in diverse biological processes. However, the potential roles of m1A regulatory‑mediated methylation modifications in multiple myeloma (MM) remain unclear. The mRNA expression of m1A regulators in normal plasma (NP; n=9) and MM (n=174) bone marrow plasma cells was investigated and the m1A modification patterns of 559 MM samples based on the expression of 10 m1A‑related regulatory genes were comprehensively evaluated. Univariate Cox regression, Kaplan‑Meier survival curve, unsupervised clustering and gene enrichment analyses were used to explore the associations between m1A‑related regulatory genes and MM patient survival/prognosis. The m1A score model was subsequently constructed to quantify the m1A modification patterns of individual tumours, and its predictive performance was further assessed via receiver operating characteristic curves. Immunohistochemistry, Cell Counting Kit‑8, flow cytometry and m1A dot blot assays were performed to investigate the potential role of YTH domain‑containing family protein 2 (YTHDF2) in MM. Moreover, bioinformatics analysis was performed to predict the potential downstream regulatory mechanism of YTHDF2. In total, seven differentially expressed genes [tRNA methyltransferase 61A/B (TRMT61A/B), YTH N6‑methyladenosine RNA binding protein (YTHD)F1/F2/F3/C1 and Alkb homolog 1, histone H2A dioxygenase (ALKBH1)] were identified in MM samples compared with those in NP samples. The forest map and Kaplan‑Meier curve revealed that the expression of m1A‑related regulatory genes could be favourable prognostic factors for patients with MM. A total of three distinct m1A modification patterns were determined, and Cluster B exhibited the worst outcome, which was accompanied by increased expression of YTHDF2, tRNA methyltransferase 6 non‑catalytic subunit (TRMT6), tRNA methyltransferase 10 homolog C (TRMT10C) and TRMT61B. The m1Ascore model was subsequently constructed. A high m1A score was associated with clinical benefit and an improved treatment response. High expression of the reader protein YTHDF2 was associated with poor survival in patients with MM and was superior to other assessed proteins in terms of prognosis. Subsequent cell experiments demonstrated that YTHDF2 promoted the proliferation and inhibited the apoptosis of U266 cells. Notably, an evident increase in the m1A level was observed when YTHDF2 was overexpressed. A total of 150 genes related to YTHDF2 were identified, and these genes were enriched in the peroxisome proliferator‑activated receptor signalling pathway, protein export, positive regulation of protein targeting to the membrane, and gamma‑delta intraepithelial T‑cell differentiation. Serine and arginine rich splicing factor 10 (SRSF10) was subsequently selected because SRSF10 expression was significantly positively correlated with YTHDF2 expression and was also associated with poor prognosis in patients with MM. The present study revealed the modification patterns and high prognostic value of m1A regulators and demonstrated that the reader protein YTHDF2 is a potentially crucial target for MM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, et al: The molecular classification of multiple myeloma. Blood. 108:2020–2028. 2006.PubMed/NCBI View Article : Google Scholar

2 

Allegra A, Casciaro M, Barone P, Musolino C and Gangemi S: Epigenetic crosstalk between malignant plasma cells and the tumour microenvironment in multiple myeloma. Cancers (Basel). 14(2597)2022.PubMed/NCBI View Article : Google Scholar

3 

He L, Yu C, Qin S, Zheng E, Liu X, Liu Y, Yu S, Liu Y, Dou X, Shang Z, et al: The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity. Mol Cell. 83:4000–4016.e6. 2023.PubMed/NCBI View Article : Google Scholar

4 

Muylaert C, Van Hemelrijck LA, Maes A, De Veirman K, Menu E, Vanderkerken K and De Bruyne E: Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity? Front Oncol. 12(979569)2022.PubMed/NCBI View Article : Google Scholar

5 

Liu R, Shen Y, Hu J, Wang X, Wu D, Zhai M, Bai J and He A: Comprehensive Analysis of m6A RNA methylation regulators in the prognosis and immune microenvironment of multiple myeloma. Front Oncol. 11(731957)2021.PubMed/NCBI View Article : Google Scholar

6 

Jin Z, MacPherson K, Liu Z and Vu LP: RNA modifications in hematological malignancies. Int J Hematol. 117:807–820. 2023.PubMed/NCBI View Article : Google Scholar

7 

Zhao BS, Roundtree IA and He C: Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 18:31–42. 2017.PubMed/NCBI View Article : Google Scholar

8 

Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, Peer E, Kol N, Ben-Haim MS, Dai Q, Di Segni A, Salmon-Divon M, Clark WC, et al: The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature. 530:441–446. 2016.PubMed/NCBI View Article : Google Scholar

9 

Yang Y, Hsu PJ, Chen YS and Yang YG: Dynamic transcriptomic m(6)A decoration: Writers, erasers, readers and functions in RNA metabolism. Cell Res. 28:616–624. 2018.PubMed/NCBI View Article : Google Scholar

10 

Liu Y, Zhang S, Gao X, Ru Y, Gu X and Hu X: Research progress of N1-methyladenosine RNA modification in cancer. Cell Commun Signal. 22(79)2024.PubMed/NCBI View Article : Google Scholar

11 

Zou Z, Sepich-Poore C, Zhou X, Wei J and He C: The mechanism underlying redundant functions of the YTHDF proteins. Genome Biol. 24(17)2023.PubMed/NCBI View Article : Google Scholar

12 

Chen Z, Qi M, Shen B, Luo G, Wu Y, Li J, Lu Z, Zheng Z, Dai Q and Wang H: Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs. Nucleic Acids Res. 47:2533–2545. 2019.PubMed/NCBI View Article : Google Scholar

13 

Liu R, Miao J, Jia Y, Kong G, Hong F, Li F, Zhai M, Zhang R, Liu J, Xu X, et al: N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition. Oncogene. 42:1607–1619. 2023.PubMed/NCBI View Article : Google Scholar

14 

Che F, Ye X, Wang Y, Wang X, Ma S, Tan Y, Mao Y and Luo Z: METTL3 facilitates multiple myeloma tumorigenesis by enhancing YY1 stability and pri-microRNA-27 maturation in m6A-dependent manner. Cell Biol Toxicol. 39:2033–2050. 2023.PubMed/NCBI View Article : Google Scholar

15 

Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R and Dutta A: TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nat Commun. 13(2165)2022.PubMed/NCBI View Article : Google Scholar

16 

Yang Z, Cai Z, Yang C, Luo Z and Bao X: ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner. EBioMedicine. 80(104019)2022.PubMed/NCBI View Article : Google Scholar

17 

Xu A, Zhang J, Zuo L, Yan H, Chen L, Zhao F, Fan F, Xu J, Zhang B, Zhang Y, et al: FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner. Mol Ther. 30:1104–1118. 2022.PubMed/NCBI View Article : Google Scholar

18 

Coira IF, Rincón R and Cuendet M: The Multiple Myeloma Landscape: Epigenetics and Non-Coding RNAs. Cancers (Basel). 14(2348)2022.PubMed/NCBI View Article : Google Scholar

19 

Agnelli L, Mosca L, Fabris S, Lionetti M, Andronache A, Kwee I, Todoerti K, Verdelli D, Battaglia C, Bertoni F, et al: A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: An integrated genomics approach reveals a wide gene dosage effect. Genes Chromosomes Cancer. 48:603–614. 2009.PubMed/NCBI View Article : Google Scholar

20 

López-Corral L, Corchete LA, Sarasquete ME, Mateos MV, García-Sanz R, Fermiñán E, Lahuerta JJ, Bladé J, Oriol A, Teruel AI, et al: Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies. Haematologica. 99:1365–1372. 2014.PubMed/NCBI View Article : Google Scholar

21 

Popovici V, Chen W, Gallas BG, Hatzis C, Shi W, Samuelson FW, Nikolsky Y, Tsyganova M, Ishkin A, Nikolskaya T, et al: Effect of training-sample size and classification difficulty on the accuracy of genomic predictors. Breast Cancer Res. 12(R5)2010.PubMed/NCBI View Article : Google Scholar

22 

Li J, Xie L, Xie Y and Wang F: Bregmannian consensus clustering for cancer subtypes analysis. Comput Methods Programs Biomed. 189(105337)2020.PubMed/NCBI View Article : Google Scholar

23 

Hänzelmann S, Castelo R and Guinney J: GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 14(7)2013.PubMed/NCBI View Article : Google Scholar

24 

Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, et al: Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst. 98:262–272. 2006.PubMed/NCBI View Article : Google Scholar

25 

Zhang B, Wu Q, Li B, Wang D, Wang L and Zhou YL: m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer. Mol Cancer. 19(53)2020.PubMed/NCBI View Article : Google Scholar

26 

Bruns I, Cadeddu RP, Brueckmann I, Fröbel J, Geyh S, Büst S, Fischer JC, Roels F, Wilk CM, Schildberg FA, et al: Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells. Blood. 120:2620–2630. 2012.PubMed/NCBI View Article : Google Scholar

27 

Garg TK, Szmania SM, Khan JA, Hoering A, Malbrough PA, Moreno-Bost A, Greenway AD, Lingo JD, Li X, Yaccoby S, et al: Highly activated and expanded natural killer cells for multiple myeloma immunotherapy. Haematologica. 97:1348–1356. 2012.PubMed/NCBI View Article : Google Scholar

28 

Garcia-Gomez A, De Las Rivas J, Ocio EM, Díaz-Rodríguez E, Montero JC, Martín M, Blanco JF, Sanchez-Guijo FM, Pandiella A, San Miguel JF and Garayoa M: Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: Implications in myeloma progression and myeloma bone disease. Oncotarget. 5:8284–8305. 2014.PubMed/NCBI View Article : Google Scholar

29 

Liu H, He J, Koh SP, Zhong Y, Liu Z, Wang Z, Zhang Y, Li Z, Tam BT, Lin P, et al: Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. Sci Transl Med. 11(eaau9087)2019.PubMed/NCBI View Article : Google Scholar

30 

Liu B, Li X, Liu F, Li F, Wei S, Liu J and Lv Y: Expression and Significance of TRIM 28 in Squamous Carcinoma of Esophagus. Pathol Oncol Res. 25:1645–1652. 2019.PubMed/NCBI View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

32 

Frapin M, Guignard S, Meistermann D, Grit I, Moullé VS, Paillé V, Parnet P and Amarger V: Maternal protein restriction in rats alters the expression of genes involved in mitochondrial metabolism and epitranscriptomics in fetal hypothalamus. Nutrients. 12(1464)2020.PubMed/NCBI View Article : Google Scholar

33 

Costa F, Vescovini R, Marchica V, Storti P, Notarfranchi L, Dalla Palma B, Toscani D, Burroughs-Garcia J, Catarozzo MT, Sammarelli G and Giuliani N: PD-L1/PD-1 pattern of expression within the bone marrow immune microenvironment in smoldering myeloma and active multiple myeloma patients. Front Immunol. 11(613007)2021.PubMed/NCBI View Article : Google Scholar

34 

Huang T, Liu Z, Zheng Y, Feng T, Gao Q and Zeng W: YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A/mRNA pathway. Cell Death Dis. 11(37)2020.PubMed/NCBI View Article : Google Scholar

35 

Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, Sun HY, Li A, Ping XL, Lai WY, et al: Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol Cell. 61:507–519. 2016.PubMed/NCBI View Article : Google Scholar

36 

Dai X, Wang T, Gonzalez G and Wang Y: Identification of YTH Domain-Containing Proteins as the Readers for N1-Methyladenosine in RNA. Anal Chem. 90:6380–6384. 2018.PubMed/NCBI View Article : Google Scholar

37 

Seo KW and Kleiner RE: YTHDF2 Recognition of N1-Methyladenosine (m1A)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 15:132–139. 2020.PubMed/NCBI View Article : Google Scholar

38 

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, et al: Targeting the RNA m6A Reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia. Cell Stem Cell. 25:137–148. e6. 2019.PubMed/NCBI View Article : Google Scholar

39 

Hua Z, Wei R, Guo M, Lin Z, Yu X, Li X, Gu C and Yang Y: YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis. Oncogene. 41:1482–1491. 2022.PubMed/NCBI View Article : Google Scholar

40 

Sha Y, Wu J, Paul B, Zhao Y, Mathews P, Li Z, Norris J, Wang E, McDonnell DP and Kang Y: PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo. Cancer Lett. 545(215832)2022.PubMed/NCBI View Article : Google Scholar

41 

Aouali N, Broukou A, Bosseler M, Keunen O, Schlesser V, Janji B, Palissot V, Stordeur P and Berchem G: Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells. PLoS One. 10(e0130339)2015.PubMed/NCBI View Article : Google Scholar

42 

Yu JT, Hu XW, Chen HY, Yang Q, Li HD, Dong YH, Zhang Y, Wang JN, Jin J, Wu YG, et al: DNA methylation of FTO promotes renal inflammation by enhancing m6A of PPAR-α in alcohol-induced kidney injury. Pharmacol Res. 163(105286)2021.PubMed/NCBI View Article : Google Scholar

43 

Long JC and Caceres JF: The SR protein family of splicing factors: Master regulators of gene expression. Biochem J. 417:15–27. 2009.PubMed/NCBI View Article : Google Scholar

44 

Longman D, Johnstone IL and Cáceres JF: Functional characterization of SR and SR-related genes in caenorhabditis elegans. EMBO J. 19:1625–1637. 2000.PubMed/NCBI View Article : Google Scholar

45 

Shkreta L, Delannoy A, Salvetti A and Chabot B: SRSF10: An atypical splicing regulator with critical roles in stress response, organ development, and viral replication. RNA. 27:1302–1317. 2021.PubMed/NCBI View Article : Google Scholar

46 

Jobbins AM, Haberman N, Artigas N, Amourda C, Paterson HAB, Yu S, Blackford SJI, Montoya A, Dore M, Wang YF, et al: Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease. Nucleic Acids Res. 50:3379–3393. 2022.PubMed/NCBI View Article : Google Scholar

47 

Maimaiti A, Tuersunniyazi A, Meng X, Pei Y, Ji W, Feng Z, Jiang L, Wang Z, Kasimu M, Wang Y and Shi X: N6-methyladenosine RNA methylation regulator-related alternative splicing gene signature as prognostic predictor and in immune microenvironment characterization of patients with low-grade glioma. Front Genet. 13(872186)2022.PubMed/NCBI View Article : Google Scholar

48 

Lai S, Wang Y, Li T, Dong Y, Lin Y, Wang L, Weng S, Zhang X and Lin C: N6-methyladenosine-mediated CELF2 regulates CD44 alternative splicing affecting tumorigenesis via ERAD pathway in pancreatic cancer. Cell Biosci. 12(125)2022.PubMed/NCBI View Article : Google Scholar

49 

Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J and Shi Y: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma. Redox Biol. 58(102546)2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fu J, Han X, Gao W, Yu M and Cui X: m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma. Exp Ther Med 29: 18, 2025.
APA
Fu, J., Han, X., Gao, W., Yu, M., & Cui, X. (2025). m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma. Experimental and Therapeutic Medicine, 29, 18. https://doi.org/10.3892/etm.2024.12768
MLA
Fu, J., Han, X., Gao, W., Yu, M., Cui, X."m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma". Experimental and Therapeutic Medicine 29.1 (2025): 18.
Chicago
Fu, J., Han, X., Gao, W., Yu, M., Cui, X."m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma". Experimental and Therapeutic Medicine 29, no. 1 (2025): 18. https://doi.org/10.3892/etm.2024.12768
Copy and paste a formatted citation
x
Spandidos Publications style
Fu J, Han X, Gao W, Yu M and Cui X: m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma. Exp Ther Med 29: 18, 2025.
APA
Fu, J., Han, X., Gao, W., Yu, M., & Cui, X. (2025). m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma. Experimental and Therapeutic Medicine, 29, 18. https://doi.org/10.3892/etm.2024.12768
MLA
Fu, J., Han, X., Gao, W., Yu, M., Cui, X."m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma". Experimental and Therapeutic Medicine 29.1 (2025): 18.
Chicago
Fu, J., Han, X., Gao, W., Yu, M., Cui, X."m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma". Experimental and Therapeutic Medicine 29, no. 1 (2025): 18. https://doi.org/10.3892/etm.2024.12768
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team