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LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1

  • Authors:
    • Jie Huang
    • Baoqing Wang
    • Qin Wu
    • Liming Wang
    • Chao Guan
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shanghai Xuhui Central Hospital, Zhongshan‑Xuhui Hospital, Fudan University, Xuhui, Shanghai 200031, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
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    Published online on: December 3, 2024
       https://doi.org/10.3892/etm.2024.12777
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Abstract

There is increasing evidence that long non‑coding (lnc)RNA EGFR‑AS1 is involved in the development of numerous types of cancer, including non‑small‑cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) demonstrates that EGFR‑AS1 is highly expressed in NSCLC. Downregulation of EGFR‑AS1 in A549 and PC9 NSCLC cells demonstrates inhibition of NSCLC proliferation, invasion and metastasis. The present study demonstrated that lncRNA EGFR‑AS1 was essential for the development of NSCLC through its function as a competitive endogenous RNA binding to miR‑449a and upregulating histone deacetylase 1. In brief, it identified a novel signaling pathway that mediated the invasion and metastasis of NSCLC and may therefore provide a new treatment target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Wang B, Wu Q, Wang L and Guan C: LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1. Exp Ther Med 29: 27, 2025.
APA
Huang, J., Wang, B., Wu, Q., Wang, L., & Guan, C. (2025). LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1. Experimental and Therapeutic Medicine, 29, 27. https://doi.org/10.3892/etm.2024.12777
MLA
Huang, J., Wang, B., Wu, Q., Wang, L., Guan, C."LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1". Experimental and Therapeutic Medicine 29.2 (2025): 27.
Chicago
Huang, J., Wang, B., Wu, Q., Wang, L., Guan, C."LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1". Experimental and Therapeutic Medicine 29, no. 2 (2025): 27. https://doi.org/10.3892/etm.2024.12777
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Wang B, Wu Q, Wang L and Guan C: LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1. Exp Ther Med 29: 27, 2025.
APA
Huang, J., Wang, B., Wu, Q., Wang, L., & Guan, C. (2025). LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1. Experimental and Therapeutic Medicine, 29, 27. https://doi.org/10.3892/etm.2024.12777
MLA
Huang, J., Wang, B., Wu, Q., Wang, L., Guan, C."LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1". Experimental and Therapeutic Medicine 29.2 (2025): 27.
Chicago
Huang, J., Wang, B., Wu, Q., Wang, L., Guan, C."LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1". Experimental and Therapeutic Medicine 29, no. 2 (2025): 27. https://doi.org/10.3892/etm.2024.12777
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