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Case Report Open Access

Occult breast cancer in an older woman: A case report

  • Authors:
    • Cong Liu
    • Hua Xing
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
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    Published online on: December 24, 2024
       https://doi.org/10.3892/etm.2024.12788
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Abstract

Occult breast cancer (OBC) is a relatively rare clinical condition that can complicate differential diagnosis efforts and delay the administration of specific treatments. The individualized therapy of patients with OBC should be performed based on their clinical symptoms, imaging findings and pathological diagnosis. The present case study describes a 51‑year‑old woman with a painless left axillary tumor. The axillary lymph nodes of the patient were affected by invasive ductal carcinoma, as determined by histological analysis. However, the primary lesion was missed by numerous testing. The patient underwent surgery and testing for positron emission tomography/computed tomography (PET/CT). The present study comprehensively examined this case and offered a systematic analysis of the relevant scholarly works on the diagnosis, treatment and prognosis of OBC. Ultrasonography revealed the presence of three homogenous hypoechoic masses with irregular margins in the left axilla of the patient. PET/CT scanning identified multiple enlarged left axillary hypermetabolic lymph nodes. After that, the patient underwent a nipple‑sparing mastectomy and an axillary lymphadenectomy. With the lymph nodes showing metastatic, infiltrating ductal carcinoma from the breast, ductal carcinoma in situ of the breast diagnosis was supported by a histological examination. Immunohistochemical staining revealed that resected lymph nodes were positive for both estrogen and progesterone receptors, consistent with the status of the breast as the primary tumor site. Following surgery, the patient underwent adjuvant chemotherapy treatment. At 12 months post‑surgery, the patient remained well without evidence of disease. OBC cases lack the typical clinical and imaging findings associated with breast cancer, and a combination of axillary lymph node examination and immunohistochemistry is essential for accurately diagnosing affected patients. Ensuring the best patient outcomes necessitates accurate and prompt diagnosis, achieved by thorough physical examination, cautious utilization of diagnostic tools, personalized surgical interventions and histological investigation.
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Liu C and Xing H: Occult breast cancer in an older woman: A case report. Exp Ther Med 29: 38, 2025.
APA
Liu, C., & Xing, H. (2025). Occult breast cancer in an older woman: A case report. Experimental and Therapeutic Medicine, 29, 38. https://doi.org/10.3892/etm.2024.12788
MLA
Liu, C., Xing, H."Occult breast cancer in an older woman: A case report". Experimental and Therapeutic Medicine 29.2 (2025): 38.
Chicago
Liu, C., Xing, H."Occult breast cancer in an older woman: A case report". Experimental and Therapeutic Medicine 29, no. 2 (2025): 38. https://doi.org/10.3892/etm.2024.12788
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C and Xing H: Occult breast cancer in an older woman: A case report. Exp Ther Med 29: 38, 2025.
APA
Liu, C., & Xing, H. (2025). Occult breast cancer in an older woman: A case report. Experimental and Therapeutic Medicine, 29, 38. https://doi.org/10.3892/etm.2024.12788
MLA
Liu, C., Xing, H."Occult breast cancer in an older woman: A case report". Experimental and Therapeutic Medicine 29.2 (2025): 38.
Chicago
Liu, C., Xing, H."Occult breast cancer in an older woman: A case report". Experimental and Therapeutic Medicine 29, no. 2 (2025): 38. https://doi.org/10.3892/etm.2024.12788
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