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Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis

  • Authors:
    • Yujing He
    • Caixia Zheng
    • Jianyong Zeng
    • Yaojie Fu
    • Hongjie Ou
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, P.R. China, Emergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: December 31, 2024
       https://doi.org/10.3892/etm.2024.12792
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Abstract

Sepsis, a condition characterized by a dysregulated host response to infection, can progress to septic shock and lead to various complications. The present study aimed to identify risk factors for the early clinical identification of sepsis patients at heightened risk of complications. In the present study, a total of 383 hospitalized patients with sepsis and positive blood cultures were enrolled. Demographic characteristics, laboratory findings at admission and treatment outcomes were collected and analyzed. Among the 383 sepsis patients, 165 were diagnosed with acute kidney injury (AKI). Patients with AKI exhibited significantly lower platelet counts, elevated procalcitonin levels and higher Sequential Organ Failure Assessment (SOFA) scores. Logistic regression analysis identified the SOFA score [odds ratio (OR)=1.269, 95% confidence interval (CI): 1.067‑1.510, P=0.007) as an independent predictor of AKI. Furthermore, patients with septic shock had lower platelet counts and higher white blood cell counts at admission. Multivariable analysis revealed that age (OR=1.024, 95% CI: 1.001‑1.047, P=0.039), procalcitonin (OR=1.018, 95% CI: 1.003‑1.032, P=0.015), SOFA score (OR=1.465, 95% CI: 1.248‑1.719, P<0.001) and Pitt bacteremia score (OR=1.437, 95% CI: 1.204‑1.716, P<0.001) were independently associated with septic shock. In addition, sepsis patients with acute respiratory distress syndrome (ARDS) were observed to have lower platelet counts, higher body weight and elevated alanine aminotransferase levels. Multivariable analysis identified the SOFA score (OR=1.177, 95% CI: 1.095‑1.265, P<0.001) and body weight (OR=1.030, 95% CI: 1.007‑1.054, P=0.010) as independent predictors of ARDS. The present study highlights the risk factors associated with AKI, ARDS and septic shock in sepsis patients with positive blood cultures. Early identification and close monitoring of these factors are crucial for improving outcomes in sepsis management.
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1 

Moore JX, Donnelly JP, Griffin R, Howard G, Safford MM and Wang HE: Defining sepsis mortality clusters in the United States. Crit Care Med. 44:1380–1387. 2016.PubMed/NCBI View Article : Google Scholar

2 

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al: Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the Global Burden of disease study. Lancet. 395:200–211. 2020.PubMed/NCBI View Article : Google Scholar

3 

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, et al: Incidence and trends of sepsis in US Hospitals using clinical vs claims data, 2009-2014. JAMA. 318:1241–1249. 2017.PubMed/NCBI View Article : Google Scholar

4 

Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD and Finfer S: Recognizing sepsis as a global health priority-A WHO resolution. New Engl J Med. 377:414–417. 2017.PubMed/NCBI View Article : Google Scholar

5 

Peerapornratana S, Manrique-Caballero CL, Gomez H and Kellum JA: Acute kidney injury from sepsis: Current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 96:1083–1099. 2019.PubMed/NCBI View Article : Google Scholar

6 

Sun B, Lei M, Zhang J, Kang H, Liu H and Zhou F: Acute lung injury caused by sepsis: How does it happen? Front Med (Lausanne). 10(1289194)2023.PubMed/NCBI View Article : Google Scholar

7 

Cecconi M, Evans L, Levy M and Rhodes A: Sepsis and septic shock. Lancet. 392:75–87. 2018.PubMed/NCBI View Article : Google Scholar

8 

Manrique-Caballero CL, Del Rio-Pertuz G and Gomez H: Sepsis-associated acute kidney injury. Crit Care Clin. 37:279–301. 2021.PubMed/NCBI View Article : Google Scholar

9 

Chang YM, Chou YT, Kan WC and Shiao CC: Sepsis and acute kidney injury: A review focusing on the bidirectional interplay. Int J Mol Sci. 23(9159)2022.PubMed/NCBI View Article : Google Scholar

10 

Angus DC and van der Poll T: Severe sepsis and septic shock. N Engl J Med. 369:840–851. 2013.PubMed/NCBI View Article : Google Scholar

11 

Chiu C and Legrand M: Epidemiology of sepsis and septic shock. Curr Opin Anaesthesiol. 34:71–76. 2021.PubMed/NCBI View Article : Google Scholar

12 

Fein AM and Calalang-Colucci MG: Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin. 16:289–317. 2000.PubMed/NCBI View Article : Google Scholar

13 

Williams B: The National early warning score: From concept to NHS implementation. Clin Med (Lond). 22:499–505. 2022.PubMed/NCBI View Article : Google Scholar

14 

Brunetti E, Isaia G, Rinaldi G, Brambati T, De Vito D, Ronco G and Bo M: Comparison of diagnostic accuracies of qSOFA, NEWS, and MEWS to identify sepsis in older inpatients with suspected infection. J Am Med Dir Assoc. 23:865–871.e2. 2022.PubMed/NCBI View Article : Google Scholar

15 

Chua WL, Rusli KDB and Aitken LM: Early warning scores for sepsis identification and prediction of in-hospital mortality in adults with sepsis: A systematic review and meta-analysis. J Clin Nurs. 33:2005–2018. 2024.PubMed/NCBI View Article : Google Scholar

16 

Ostermann M, Zarbock A, Goldstein S, Kashani K, Macedo E, Murugan R, Bell M, Forni L, Guzzi L, Joannidis M, et al: Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: A consensus statement. JAMA Netw Open. 3(e2019209)2020.PubMed/NCBI View Article : Google Scholar

17 

Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, et al: Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 46:1222–1231. 2020.PubMed/NCBI View Article : Google Scholar

18 

Gotts JE and Matthay MA: Sepsis: Pathophysiology and clinical management. BMJ. 353(i1585)2016.PubMed/NCBI View Article : Google Scholar

19 

Zhang J, Yan W, Dong Y, Luo X, Miao H, Maimaijuma T, Xu X, Jiang H, Huang Z, Qi L and Liang G: Early identification and diagnosis, pathophysiology, and treatment of sepsis-related acute lung injury: A narrative review. J Thorac Dis. 16:5457–5476. 2024.PubMed/NCBI View Article : Google Scholar

20 

Yoon J, Kym D, Hur J, Park J, Kim M, Cho YS, Chun W and Yoon D: The clinical differentiation of blood culture-positive and -negative sepsis in burn patients: A retrospective cohort study. Burns Trauma. 11(tkad031)2023.PubMed/NCBI View Article : Google Scholar

21 

Afzal MS, Nandan Chennuri R, Naveed H, Raveena Bai B, Hanif R, Shahzad Z, Umer M and Saleem F: Comparison of clinical outcomes between culture-positive and culture-negative sepsis and septic shock patients: A meta-analysis. Cureus. 15(e35416)2023.PubMed/NCBI View Article : Google Scholar

22 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al: The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 315:801–810. 2016.PubMed/NCBI View Article : Google Scholar

23 

ARDS Definition Task Force. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS: Acute respiratory distress syndrome: The Berlin Definition. JAMA. 307:2526–2533. 2012.PubMed/NCBI View Article : Google Scholar

24 

Khwaja A: KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 120:c179–c184. 2012.PubMed/NCBI View Article : Google Scholar

25 

de Prost N, Razazi K and Brun-Buisson C: Unrevealing culture-negative severe sepsis. Crit Care. 17(1001)2013.PubMed/NCBI View Article : Google Scholar

26 

Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS and Wenzel RP: The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 273:117–123. 1995.PubMed/NCBI

27 

Li Y, Guo J, Yang H, Li H, Shen Y and Zhang D: Comparison of culture-negative and culture-positive sepsis or septic shock: A systematic review and meta-analysis. Crit Care. 25(167)2021.PubMed/NCBI View Article : Google Scholar

28 

Liu J, Xie H, Ye Z, Li F and Wang L: Rates, predictors, and mortality of sepsis-associated acute kidney injury: A systematic review and meta-analysis. BMC Nephrol. 21(318)2020.PubMed/NCBI View Article : Google Scholar

29 

Yang L, Lin Y, Wang J, Song J, Wei B, Zhang X, Yang J and Liu B: Comparison of clinical characteristics and outcomes between positive and negative blood culture septic patients: A retrospective cohort study. Infect Drug Resist. 14:4191–4205. 2021.PubMed/NCBI View Article : Google Scholar

30 

Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S and Kadomatsu K: miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury. Lab Invest. 99:1130–1142. 2019.PubMed/NCBI View Article : Google Scholar

31 

Chen Y, Dabbas W, Gangemi A, Benedetti E, Lash J, Finn PW and Perkins DL: Obesity management and chronic kidney disease. Semin Nephrol. 41:392–402. 2021.PubMed/NCBI View Article : Google Scholar

32 

Jiang Z, Wang Y, Zhao X, Cui H, Han M, Ren X, Gang X and Wang G: Obesity and chronic kidney disease. Am J Physiol Endocrinol Metab. 324:E24–E41. 2023.PubMed/NCBI View Article : Google Scholar

33 

Escasany E, Izquierdo-Lahuerta A and Medina-Gomez G: Underlying mechanisms of renal lipotoxicity in obesity. Nephron. 143:28–32. 2019.PubMed/NCBI View Article : Google Scholar

34 

Martin-Taboada M, Vila-Bedmar R and Medina-Gomez G: From obesity to chronic kidney disease: How can adipose tissue affect renal function? Nephron. 145:609–613. 2021.PubMed/NCBI View Article : Google Scholar

35 

Diaz-Lopez A, Becerra-Tomas N, Ruiz V, Toledo E, Babio N, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, et al: Effect of an intensive weight-loss lifestyle intervention on kidney function: A randomized controlled trial. Am J Nephrol. 52:45–58. 2021.PubMed/NCBI View Article : Google Scholar

36 

Spurny M, Jiang Y, Sowah SA, Nonnenmacher T, Schübel R, Kirsten R, Johnson T, von Stackelberg O, Ulrich CM, Kaaks R, et al: Changes in kidney fat upon dietary-induced weight loss. Nutrients. 14(1437)2022.PubMed/NCBI View Article : Google Scholar

37 

Bolignano D and Zoccali C: Effects of weight loss on renal function in obese CKD patients: A systematic review. Nephrol Dial Transplant 28 Suppl. 4:v82–v98. 2013.PubMed/NCBI View Article : Google Scholar

38 

Morrell ED, Kellum JA, Pastor-Soler NM and Hallows KR: Septic acute kidney injury: Molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 18(501)2014.PubMed/NCBI View Article : Google Scholar

39 

Dellepiane S, Marengo M and Cantaluppi V: Detrimental cross-talk between sepsis and acute kidney injury: New pathogenic mechanisms, early biomarkers and targeted therapies. Crit Care. 20(61)2016.PubMed/NCBI View Article : Google Scholar

40 

Alobaidi R, Basu RK, Goldstein SL and Bagshaw SM: Sepsis-associated acute kidney injury. Semin Nephrol. 35:2–11. 2015.PubMed/NCBI View Article : Google Scholar

41 

Sauter RJ, Sauter M, Obrich M, Emschermann FN, Nording H, Patzelt J, Wendel HP, Reil JC, Edlich F and Langer HF: Anaphylatoxin receptor C3aR contributes to platelet function, thrombus formation and in vivo haemostasis. Thromb Haemost. 119:179–182. 2019.PubMed/NCBI View Article : Google Scholar

42 

Gill P, Jindal NL, Jagdis A and Vadas P: Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. J Allergy Clin Immunol. 135:1424–1432. 2015.PubMed/NCBI View Article : Google Scholar

43 

Verschoor A, Neuenhahn M, Navarini AA, Graef P, Plaumann A, Seidlmeier A, Nieswandt B, Massberg S, Zinkernagel RM, Hengartner H and Busch DH: A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol. 12:1194–1201. 2011.PubMed/NCBI View Article : Google Scholar

44 

Zhang F, Brenner M, Yang WL and Wang P: A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice. Sci Rep. 8(3052)2018.PubMed/NCBI View Article : Google Scholar

45 

Yu Y, Jing L, Zhang X and Gao C: Simvastatin attenuates acute lung injury via regulating CDC42-PAK4 and endothelial microparticles. Shock. 47:378–384. 2017.PubMed/NCBI View Article : Google Scholar

46 

Sharp C, Millar AB and Medford AR: Advances in understanding of the pathogenesis of acute respiratory distress syndrome. Respiration. 89:420–434. 2015.PubMed/NCBI View Article : Google Scholar

47 

Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG and Calfee CS: Acute respiratory distress syndrome. Nat Rev Dis Primers. 5(18)2019.PubMed/NCBI View Article : Google Scholar

48 

Yao RQ, Ren C, Zheng LY, Xia ZF and Yao YM: Advances in immune monitoring approaches for sepsis-induced immunosuppression. Front Immunol. 13(891024)2022.PubMed/NCBI View Article : Google Scholar

49 

de Grooth HJ, Geenen IL, Girbes AR, Vincent JL, Parienti JJ and Oudemans-van Straaten HM: SOFA and mortality endpoints in randomized controlled trials: A systematic review and meta-regression analysis. Crit Care. 21(38)2017.PubMed/NCBI View Article : Google Scholar

50 

Lambden S, Laterre PF, Levy MM and Francois B: The SOFA score-development, utility and challenges of accurate assessment in clinical trials. Crit Care. 23(374)2019.PubMed/NCBI View Article : Google Scholar

51 

Qiu X, Lei YP and Zhou RX: SIRS, SOFA, qSOFA, and NEWS in the diagnosis of sepsis and prediction of adverse outcomes: A systematic review and meta-analysis. Expert Rev Anti Infect Ther. 21:891–900. 2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
He Y, Zheng C, Zeng J, Fu Y and Ou H: Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis. Exp Ther Med 29: 42, 2025.
APA
He, Y., Zheng, C., Zeng, J., Fu, Y., & Ou, H. (2025). Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis. Experimental and Therapeutic Medicine, 29, 42. https://doi.org/10.3892/etm.2024.12792
MLA
He, Y., Zheng, C., Zeng, J., Fu, Y., Ou, H."Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis". Experimental and Therapeutic Medicine 29.2 (2025): 42.
Chicago
He, Y., Zheng, C., Zeng, J., Fu, Y., Ou, H."Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis". Experimental and Therapeutic Medicine 29, no. 2 (2025): 42. https://doi.org/10.3892/etm.2024.12792
Copy and paste a formatted citation
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Spandidos Publications style
He Y, Zheng C, Zeng J, Fu Y and Ou H: Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis. Exp Ther Med 29: 42, 2025.
APA
He, Y., Zheng, C., Zeng, J., Fu, Y., & Ou, H. (2025). Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis. Experimental and Therapeutic Medicine, 29, 42. https://doi.org/10.3892/etm.2024.12792
MLA
He, Y., Zheng, C., Zeng, J., Fu, Y., Ou, H."Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis". Experimental and Therapeutic Medicine 29.2 (2025): 42.
Chicago
He, Y., Zheng, C., Zeng, J., Fu, Y., Ou, H."Risk factors of acute kidney injury, septic shock and acute respiratory distress syndrome in patients with blood culture‑positive sepsis". Experimental and Therapeutic Medicine 29, no. 2 (2025): 42. https://doi.org/10.3892/etm.2024.12792
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