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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2025 Volume 29 Issue 2

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Case Report

Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report

  • Authors:
    • Suha Shraim
    • Wejdan Al‑Ettewi
    • Ismaiel Abu Mahfouz
    • Mais Al‑Attar
    • Anwar Al‑Masri

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Specialty Hospital, Amman 11194, Jordan, Department of Obstetrics and Gynecology, Faculty of Medicine, Al‑Balqa Applied University, Al‑Salt 19117, Jordan, Department of Histopathology, Specialty Hospital, Amman 11194, Jordan
  • Article Number: 44
    |
    Published online on: January 3, 2025
       https://doi.org/10.3892/etm.2025.12794
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Abstract

In the present case, a 66‑year‑old woman presented to the Specialty Hospital (Amman, Jordan) with recurrent post‑menopausal bleeding. A pelvic ultrasound scan showed an abnormal endometrial thickness of 8 mm and no adnexal masses. An endometrial biopsy revealed abundant foamy histiocyte infiltration features suggestive of xanthogranulomatous endometritis. Subsequently, a total abdominal hysterectomy and bilateral salpingo‑oophorectomy were performed, before histopathology confirmed the co‑existence of uterine malakoplakia (MP) and Rosai‑Dorfman disease (RDD). The patient had recurrent admissions for abscess drainage and pneumonia. MP and RDD of the uterus are both rare inflammatory diseases characterized by the histiocytic infiltration of the endometrium, which can occasionally be misdiagnosed as cancer and associated with an increased risk of systemic infections. The present case report shows that surgical resection provides a definite diagnosis and treatment guidance of this disease, potentially reducing the inflammatory process and recurrence rate. To the best of our knowledge, the present case report was the first of the coexistence of uterine RDD and MP.
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Copy and paste a formatted citation
Spandidos Publications style
Shraim S, Al‑Ettewi W, Mahfouz IA, Al‑Attar M and Al‑Masri A: Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report. Exp Ther Med 29: 44, 2025.
APA
Shraim, S., Al‑Ettewi, W., Mahfouz, I.A., Al‑Attar, M., & Al‑Masri, A. (2025). Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report. Experimental and Therapeutic Medicine, 29, 44. https://doi.org/10.3892/etm.2025.12794
MLA
Shraim, S., Al‑Ettewi, W., Mahfouz, I. A., Al‑Attar, M., Al‑Masri, A."Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report". Experimental and Therapeutic Medicine 29.2 (2025): 44.
Chicago
Shraim, S., Al‑Ettewi, W., Mahfouz, I. A., Al‑Attar, M., Al‑Masri, A."Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report". Experimental and Therapeutic Medicine 29, no. 2 (2025): 44. https://doi.org/10.3892/etm.2025.12794
Copy and paste a formatted citation
x
Spandidos Publications style
Shraim S, Al‑Ettewi W, Mahfouz IA, Al‑Attar M and Al‑Masri A: Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report. Exp Ther Med 29: 44, 2025.
APA
Shraim, S., Al‑Ettewi, W., Mahfouz, I.A., Al‑Attar, M., & Al‑Masri, A. (2025). Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report. Experimental and Therapeutic Medicine, 29, 44. https://doi.org/10.3892/etm.2025.12794
MLA
Shraim, S., Al‑Ettewi, W., Mahfouz, I. A., Al‑Attar, M., Al‑Masri, A."Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report". Experimental and Therapeutic Medicine 29.2 (2025): 44.
Chicago
Shraim, S., Al‑Ettewi, W., Mahfouz, I. A., Al‑Attar, M., Al‑Masri, A."Rare histopathological diagnosis of malakoplakia and Rosai‑Dorfman disease in the same uterus mimicking malignancy: A case report". Experimental and Therapeutic Medicine 29, no. 2 (2025): 44. https://doi.org/10.3892/etm.2025.12794
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