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Article

Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia

  • Authors:
    • Fatma Yilmaz
    • Derya Insal Saygili
    • Bugra Saglam
    • Merih Reis Aras
    • Hacer Berna Afacan Ozturk
    • Ahmet Kursad Gunes
    • Murat Albayrak
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Etlik City Hospital, Ankara 06170, Turkey, Faculty of Medicine, Department of Internal Medicine, Harran Univercity, Şanlıurfa 63290, Turkey, Department of Hematology, Medical Point Hospital, Gaziantep 27584, Turkey
  • Article Number: 45
    |
    Published online on: January 8, 2025
       https://doi.org/10.3892/etm.2025.12795
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Abstract

Whilst severe liver dysfunction is rarely encountered at the time of diagnosis for patients with acute myeloid leukemia (AML), mild elevations aminotransferase (<5 times the upper limit of normal) may be more frequently seen. Liver dysfunction at the time of diagnosis of AML is a parameter that requires investigation and can assist the clinicians in predicting prognosis. The aim of the present study was to investigate liver dysfunction at the time of diagnosis using the assoicated parameters in patients with AML. The present retrospective study included 90 patients diagnosed with AML who were hospitalised in the Hematology Clinic of Dışkapı Yıldırım Beyazıt Training and Research Hospital (Ankara, Turkey). The demographic characteristics of the patients were recorded together with hemogram results, anemia parameters, measurable residual disease positivity (MRD) and risk category, the presence of hepatosplenomegaly, infection, neutrophil recovery time (NRT), platelet recovery time (PRT) and liver dysfunction. The patients were analyzed in two groups following sorting into the liver dysfunction (n=45) and normal liver function test group (n=45). In the analysis of independent quantitative data (age, white blood cell count, hemoglobin, platelet, international normalized ratio, albumin, B12 vitamin, NRT, PRT) the Mann Whitney U‑test was used. Independent qualitative data (sex, hepatomegaly, splenomegaly, MRD, risk category, infection) were analyzed using the χ2 test or the Fischer test. The effect level was investigated using univariate and multivariate logistic regression. A receiver operating characteristic curve was applied to determine the effect level and cut‑off values. In the group with liver dysfunction, NRT, PRT, MRD positivity, risk category and the presence of infection were found to be statistically significantly higher. These findings suggest that during the first evaluation of patients diagnosed with AML, liver function tests are simple, rapid and necessary. The results obtained in the present study showed that liver dysfunction at diagnosis can be associated with the high‑risk group, in addition to more frequent infection, poorer prognosis and mortality.
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Copy and paste a formatted citation
Spandidos Publications style
Yilmaz F, Saygili DI, Saglam B, Aras MR, Afacan Ozturk HB, Gunes AK and Albayrak M: Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia. Exp Ther Med 29: 45, 2025.
APA
Yilmaz, F., Saygili, D.I., Saglam, B., Aras, M.R., Afacan Ozturk, H.B., Gunes, A.K., & Albayrak, M. (2025). Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia. Experimental and Therapeutic Medicine, 29, 45. https://doi.org/10.3892/etm.2025.12795
MLA
Yilmaz, F., Saygili, D. I., Saglam, B., Aras, M. R., Afacan Ozturk, H. B., Gunes, A. K., Albayrak, M."Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia". Experimental and Therapeutic Medicine 29.2 (2025): 45.
Chicago
Yilmaz, F., Saygili, D. I., Saglam, B., Aras, M. R., Afacan Ozturk, H. B., Gunes, A. K., Albayrak, M."Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia". Experimental and Therapeutic Medicine 29, no. 2 (2025): 45. https://doi.org/10.3892/etm.2025.12795
Copy and paste a formatted citation
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Spandidos Publications style
Yilmaz F, Saygili DI, Saglam B, Aras MR, Afacan Ozturk HB, Gunes AK and Albayrak M: Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia. Exp Ther Med 29: 45, 2025.
APA
Yilmaz, F., Saygili, D.I., Saglam, B., Aras, M.R., Afacan Ozturk, H.B., Gunes, A.K., & Albayrak, M. (2025). Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia. Experimental and Therapeutic Medicine, 29, 45. https://doi.org/10.3892/etm.2025.12795
MLA
Yilmaz, F., Saygili, D. I., Saglam, B., Aras, M. R., Afacan Ozturk, H. B., Gunes, A. K., Albayrak, M."Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia". Experimental and Therapeutic Medicine 29.2 (2025): 45.
Chicago
Yilmaz, F., Saygili, D. I., Saglam, B., Aras, M. R., Afacan Ozturk, H. B., Gunes, A. K., Albayrak, M."Potential effects of liver dysfunction at the time of diagnosis in patients with acute myeloid leukemia". Experimental and Therapeutic Medicine 29, no. 2 (2025): 45. https://doi.org/10.3892/etm.2025.12795
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