Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2025 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2025 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?

  • Authors:
    • Jasmin Asberger
    • Isabell Ge
    • Benjamin Schmidt
    • Markus Jäger
    • Daniela Weiss
    • Kai Berner
    • Thalia Erbes
    • Ingolf Juhasz-Böss
    • Sebastian Mayer
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Medical Center, University of Freiburg, D-79106 Freiburg, Germany, Faculty of Medicine, University of Freiburg, D-79110 Freiburg, Germany
    Copyright: © Asberger et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 54
    |
    Published online on: January 22, 2025
       https://doi.org/10.3892/etm.2025.12804
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer represents the most common type of cancer in females worldwide. The survival rates for breast cancer patients have been increasing since 1990. However, in 2023 breast cancer is still the second most common cause of malignancy‑associated death in women. One decisive reason is the increase of treatment resistance and low therapy response. Therefore, new therapy targets and predictive markers for the response to treatment are needed. The present study analyzed the potential effects triggered by different breast cancer treatments on the transcriptional expression of 12 pre‑selected long non‑coding (lnc) RNAs and the proliferation markers Cyclin D1 and Ki‑67 in six different breast cancer cell lines (BT‑474, MDA‑MB‑231, BT‑20, T‑47D, SKBR‑3 and MCF‑7). The results revealed that lncRNA cytoskeleton regulator RNA may be an appropriate biomarker for the response to treatment with both epirubicin and gemcitabine (P<0.001). NF‑ĸB interacting lnc RNA may be a marker for therapy response (P<0.001), while HOX transcript antisense RNA overexpression suggested resistance to treatment (P<0.001) with epirubicin. The transcriptional expression of lncRNA BC4 increased during treatment with epirubicin and gemcitabine, which indicated therapy response. Overall, the present data suggested that the aforementioned lncRNAs have a promising potential as biomarkers to detect early therapy response or resistance in and therefore should be analyzed in more detail.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.PubMed/NCBI View Article : Google Scholar

3 

Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X and Perou CM: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 12(R68)2010.PubMed/NCBI View Article : Google Scholar

4 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000.PubMed/NCBI View Article : Google Scholar

5 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001.PubMed/NCBI View Article : Google Scholar

6 

Harbeck N and Gnant M: Breast cancer. Lancet. 389:1134–1150. 2017.PubMed/NCBI View Article : Google Scholar

7 

Teshome M and Hunt KK: Neoadjuvant therapy in the treatment of breast cancer. Surg Oncol Clin N Am. 23:505–523. 2014.PubMed/NCBI View Article : Google Scholar

8 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 365:1687–1717. 2005.PubMed/NCBI View Article : Google Scholar

9 

Rani A, Stebbing J, Giamas G and Murphy J: Endocrine resistance in hormone receptor positive breast cancer-from mechanism to therapy. Front Endocrinol (Lausanne). 10(245)2019.PubMed/NCBI View Article : Google Scholar

10 

Gilbert LA and Hemann MT: DNA damage-mediated induction of a chemoresistant niche. Cell. 143:355–366. 2010.PubMed/NCBI View Article : Google Scholar

11 

Kellokumpu-Lehtinen P, Tuunanen T, Asola R, Elomaa L, Heikkinen M, Kokko R, Järvenpää R, Lehtinen I, Maiche A, Kaleva-Kerola J, et al: Weekly paclitaxel-an effective treatment for advanced breast cancer. Anticancer Res. 33:2623–2627. 2013.PubMed/NCBI

12 

Bergh J, Jonsson PE, Glimelius B and Nygren P: SBU-group. Swedish Council of Technology Assessment in Health Care: A systematic overview of chemotherapy effects in breast cancer. Acta Oncol. 40:253–281. 2001.PubMed/NCBI View Article : Google Scholar

13 

Khasraw M, Bell R and Dang C: Epirubicin: Is it like doxorubicin in breast cancer? A clinical review. Breast. 21:142–149. 2012.PubMed/NCBI View Article : Google Scholar

14 

Seidman AD: Gemcitabine as single-agent therapy in the management of advanced breast cancer. Oncology (Williston Park). 15 (2 Suppl 3):S11–S14. 2001.PubMed/NCBI

15 

Bonadonna G, Gianni L, Santoro A, Bonfante V, Bidoli P, Casali P, Demicheli R and Valagussa P: Drugs ten years later: Epirubicin. Ann Oncol. 4:359–369. 1993.PubMed/NCBI View Article : Google Scholar

16 

Weaver BA: How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 25:2677–2681. 2014.PubMed/NCBI View Article : Google Scholar

17 

Huang P, Chubb S, Hertel LW, Grindey GB and Plunkett W: Action of 2',2'-difluorodeoxycytidine on DNA synthesis. Cancer Res. 51:6110–6117. 1991.PubMed/NCBI

18 

Carlson RW: The history and mechanism of action of fulvestrant. Clin Breast Cancer. 6 (Suppl 1):S5–S8. 2005.PubMed/NCBI View Article : Google Scholar

19 

Lee CI, Goodwin A and Wilcken N: Fulvestrant for hormone-sensitive metastatic breast cancer. Cochrane Database Syst Rev. 1(Cd011093)2017.PubMed/NCBI View Article : Google Scholar

20 

Biskup E, Cai F and Vetter M: Bone targeted therapies in advanced breast cancer. Swiss Med Wkly. 147(w14440)2017.PubMed/NCBI View Article : Google Scholar

21 

Van Poznak CH: The use of bisphosphonates in patients with breast cancer. Cancer control. 9:480–489. 2002.PubMed/NCBI View Article : Google Scholar

22 

Coleman R: The use of bisphosphonates in cancer treatment. Ann N Y Acad Sci. 1218:3–14. 2011.PubMed/NCBI View Article : Google Scholar

23 

Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, et al: The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 47:199–208. 2015.PubMed/NCBI View Article : Google Scholar

24 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012.PubMed/NCBI View Article : Google Scholar

25 

Majidinia M and Yousefi B: Long non-coding RNAs in cancer drug resistance development. DNA Repair (Amst). 45:25–33. 2016.PubMed/NCBI View Article : Google Scholar

26 

Xue X, Yang YA, Zhang A, Fong KW, Kim J, Song B, Li S, Zhao JC and Yu J: LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer. Oncogene. 35:2746–2755. 2016.PubMed/NCBI View Article : Google Scholar

27 

Wu J, Shuang Z, Zhao J, Tang H, Liu P, Zhang L, Xie X and Xiao X: Linc00152 promotes tumorigenesis by regulating DNMTs in triple-negative breast cancer. Biomed Pharmacother. 97:1275–1281. 2018.PubMed/NCBI View Article : Google Scholar

28 

Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermuller J, Hofacker IL, et al: RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 316:1484–1488. 2007.PubMed/NCBI View Article : Google Scholar

29 

Malih S, Saidijam M and Malih N: A brief review on long noncoding RNAs: A new paradigm in breast cancer pathogenesis, diagnosis and therapy. Tumor Biol. 37:1479–1485. 2016.PubMed/NCBI View Article : Google Scholar : [CrossRef] [PubMed] 4 Wang J, Ye C, Xiong H, Shen Y, Lu Y, Zhou J and Wang L: Dysregulation of long non-coding RNA in breast cancer: An overview of mechanism and clinical implication. Oncotarget 8: 5508-5522, 2017.

30 

Wang Q, Gao S, Li H, Lv M and Lu C: Long Non-coding RNAs inTriple Negative Breast Cancer. J Cell Physiol. 232:3226–3233. 2017.PubMed/NCBI View Article : Google Scholar : [CrossRef] [PubMed] 279. Warburton AJ and Boone DN: Insights from global analyses of long noncoding RNAs in breast cancer. Curr Pathobiol Rep 5: 23-34, 2017.

31 

Tian T, Wang M, Lin S, Guo Y, Dai Z, Liu K, Yang P, Dai C, Zhu Y, Zheng Y, et al: The impact of lncRNA dysregulation on clinicopathology and survival of breast cancer: A systematic review and meta-analysis. Mol Ther Nucleic Acids. 12:359–369. 2018.PubMed/NCBI View Article : Google Scholar

32 

Hashmi AA, Hashmi KA, Irfan M, Khan SM, Edhi MM, Ali JP, Hashmi SK, Asif H, Faridi N and Khan A: Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters. BMC Res Notes. 12(605)2019.PubMed/NCBI View Article : Google Scholar

33 

Kreipe H, Harbeck N and Christgen M: Clinical validity and clinical utility of Ki67 in early breast cancer. Ther Adv Med Oncol. 14(17588359221122725)2022.PubMed/NCBI View Article : Google Scholar

34 

Montalto FI and De Amicis F: Cyclin D1 in Cancer: A molecular connection for cell cycle control, adhesion and invasion in tumor and stroma. Cells. 9(2648)2020.PubMed/NCBI View Article : Google Scholar

35 

Shi Q, Li Y, Li S, Jin L, Lai H, Wu Y, Cai Z, Zhu M, Li Q, Li Y, et al: LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer. Nat Commun. 11(5513)2020.PubMed/NCBI View Article : Google Scholar

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

37 

Thompson, David M and Yan Daniel Zhao: Choosing statistical models to assess biological interaction as a departure from additivity of effects. arXiv:2301.03349, 2023.

38 

Cao Q, Wang H, Zhu J, Qi C, Huang H and Chu X: lncRNA CYTOR promotes lung adenocarcinoma gemcitabine resistance and epithelial-mesenchymal transition by sponging miR-125a-5p and upregulating ANLN and RRM2. Acta Biochim Biophys Sin (Shanghai). 56:210–222. 2024.PubMed/NCBI View Article : Google Scholar

39 

Chen S, Yang M, Wang C, Ouyang Y, Chen X, Bai J, Hu Y, Song M, Zhang S and Zhang Q: Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma. Cancer Lett. 503:43–53. 2021.PubMed/NCBI View Article : Google Scholar

40 

Liu Y, Li M, Yu H and Piao H: lncRNA CYTOR promotes tamoxifen resistance in breast cancer cells via sponging miR-125a-5p. Int J Mol Med. 45:497–509. 2020.PubMed/NCBI View Article : Google Scholar

41 

Yang J, Ma Q, Zhang M and Zhang W: LncRNA CYTOR drives L-OHP resistance and facilitates the epithelial-mesenchymal transition of colon carcinoma cells via modulating miR-378a-5p/SERPINE1. Cell Cycle. 20:1415–1430. 2021.PubMed/NCBI View Article : Google Scholar

42 

Yue B, Liu C, Sun H, Liu M, Song C, Cui R, Qiu S and Zhong M: A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/β-Catenin signaling promotes metastasis of colon cancer. Mol Ther. 26:1287–1298. 2018.PubMed/NCBI View Article : Google Scholar

43 

Yu J, Shen T, Li Y, Hao T, Yang L, Li H, Piao XM, Zhang Z, Zhu S, Quan C, et al: CYTOR drives prostate cancer progression via facilitating AR-V7 generation and its oncogenic signalling. Clin Transl Med. 13(e1230)2023.PubMed/NCBI View Article : Google Scholar

44 

Liang J, Wei X, Liu Z, Cao D, Tang Y, Zou Z, Zhou C and Lu Y: Long noncoding RNA CYTOR in cancer: A TCGA data review. Clin Chim Acta. 483:227–233. 2018.PubMed/NCBI View Article : Google Scholar

45 

Van Grembergen O, Bizet M, de Bony EJ, Calonne E, Putmans P, Brohée S, Olsen C, Guo M, Bontempi G, Sotiriou C, et al: Portraying breast cancers with long noncoding RNAs. Sci Adv. 2(e1600220)2016.PubMed/NCBI View Article : Google Scholar

46 

Malhotra A, Jain M, Prakash H, Vasquez KM and Jain A: The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer. Oncotarget. 8:110671–110684. 2017.PubMed/NCBI View Article : Google Scholar

47 

Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, et al: HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Med. 7(108)2015.PubMed/NCBI View Article : Google Scholar

48 

Jiang J, Wang S, Wang Z, Cai J, Han L, Xie L, Han Q, Wang W, Zhang Y, He X and Yang C: HOTAIR promotes paclitaxel resistance by regulating CHEK1 in ovarian cancer. Cancer Chemother Pharmacol. 86:295–305. 2020.PubMed/NCBI View Article : Google Scholar

49 

Guo J, Dou D, Zhang T and Wang B: HOTAIR promotes cisplatin resistance of osteosarcoma cells by regulating cell proliferation, invasion, and apoptosis via miR-106a-5p/STAT3 Axis. Cell Transplant. 29(963689720948447)2020.PubMed/NCBI View Article : Google Scholar

50 

Wang H, Qin R, Guan A, Yao Y, Huang Y, Jia H, Huang W and Gao J: HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR-217 expression. J Cell Biochem. 119:7226–7234. 2018.PubMed/NCBI View Article : Google Scholar

51 

Wang X, Yu X, Xu H, Wei K, Wang S, Wang Y and Han J: Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism. Cell Death Dis. 13(344)2022.PubMed/NCBI View Article : Google Scholar

52 

Li D, Li C, Chen Y, Teng L, Cao Y, Wang W, Pan H, Xu Y and Yang D: LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells. Cancer Cell Int. 20(338)2022.PubMed/NCBI View Article : Google Scholar

53 

Cheng C, Qin Y, Zhi Q, Wang J and Qin C: Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/β-catenin signaling pathways by up-regulating miR-34a. Int J Biol Macromol. 107 (Pt B):2620–2629. 2018.PubMed/NCBI View Article : Google Scholar

54 

Wang Q, Li X, Ren S, Su C, Li C, Li W, Yu J, Cheng N and Zhou C: HOTAIR induces EGFR-TKIs resistance in non-small cell lung cancer through epithelial-mesenchymal transition. Lung Cancer. 147:99–105. 2020.PubMed/NCBI View Article : Google Scholar

55 

Wang L, Dong P, Wang W, Huang M and Tian B: Gemcitabine treatment causes resistance and malignancy of pancreatic cancer stem-like cells via induction of lncRNA HOTAIR. Exp Ther Med. 14:4773–4780. 2017.PubMed/NCBI View Article : Google Scholar

56 

Milevskiy MJ, Al-Ejeh F, Saunus JM, Northwood KS, Bailey PJ, Betts JA, McCart Reed AE, Nephew KP, Stone A, Gee JM, et al: Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Hum Mol Genet. 25:3269–3283. 2016.PubMed/NCBI View Article : Google Scholar

57 

Lasfargues EY and Ozzello L: Cultivation of human breast carcinomas. J Natl Cancer Inst. 21:1131–1147. 1958.PubMed/NCBI

58 

Trempe GL: Human breast cancer in culture. Recent Results Cancer Res 33-41, 1976.

59 

Wu W, Chen F, Cui X, Yang L, Chen J, Zhao J, Huang D, Liu J, Yang L, Zeng J, et al: LncRNA NKILA suppresses TGF-β-induced epithelial-mesenchymal transition by blocking NF-κB signaling in breast cancer. Int J Cancer. 143:2213–2224. 2018.PubMed/NCBI View Article : Google Scholar

60 

Liu B, Sun L, Liu Q, Gong C, Yao Y, Lv X, Lin L, Yao H, Su F, Li D, et al: A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell. 27:370–381. 2015.PubMed/NCBI View Article : Google Scholar

61 

Godinho M, Meijer D, Setyono-Han B, Dorssers LC and van Agthoven T: Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells. J Cell Physiol. 226:1741–1749. 2011.PubMed/NCBI View Article : Google Scholar

62 

Tian D, Sun S and Lee JT: The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell. 143:390–403. 2010.PubMed/NCBI View Article : Google Scholar

63 

Redis RS, Sieuwerts AM, Look MP, et al: CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget. 4:1748–1762. 2013.PubMed/NCBI View Article : Google Scholar

64 

Wu ZJ, Li Y, Wu YZ, et al: Long non-coding RNA CCAT2 promotes the breast cancer growth and metastasis by regulating TGF-β signaling pathway. European review for medical and pharmacological sciences. 21:706–714. 2017.PubMed/NCBI

65 

Xu S, Sui S, Zhang J, et al: Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer. Int J Clin Exp Pathol. 8:4881–4891. 2015.PubMed/NCBI

66 

Zhou J, Ding D, Wang M and Cong YS: Telomerase reverse transcriptase in the regulation of gene expression. BMB reports. 47:8–14. 2014.PubMed/NCBI View Article : Google Scholar

67 

Ding X, Zhu L, Ji T, et al: Long intergenic non-coding RNAs (LincRNAs) identified by RNA-seq in breast cancer. PloS one. 9(e103270)2014.PubMed/NCBI View Article : Google Scholar

68 

Huang YS, Chang CC, Lee SS, Jou YS and Shih HM: Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 7:43256–43266. 2016.PubMed/NCBI View Article : Google Scholar

69 

Zheng R, Lin S, Guan L, et al: Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochemical and biophysical research communications. 498:1002–1008. 2018.PubMed/NCBI View Article : Google Scholar

70 

Li Z, Tian T, Hu X, et al: Six1 mediates resistance to paclitaxel in breast cancer cells. Biochemical and biophysical research communications. 441:538–543. 2013.PubMed/NCBI View Article : Google Scholar

71 

Pohl SG, Brook N, Agostino M, Arfuso Pohl SG, Brook N, Agostino M, Arfuso F, Kumar AP and Dharmarajan A: Wnt signaling in triple-negative breast cancer. Oncogenesis. 6(e310)2017.PubMed/NCBI View Article : Google Scholar

72 

Li T, Zhu J, Wang X, Chen G, Sun L, Zuo S, Zhang J, Chen S, Ma J, Yao Z, et al: Long non-coding RNA lncTCF7 activates the Wnt/β-catenin pathway to promote metastasis and invasion in colorectal cancer. Oncol Lett. 14:7384–7390. 2017.PubMed/NCBI View Article : Google Scholar

73 

Reiche K, Kasack K, Schreiber S, Lüders T, Due EU, Naume B, Riis M, Kristensen VN, Horn F, Børresen-Dale AL, et al: Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes. PLoS One. 9(e106076)2014.PubMed/NCBI View Article : Google Scholar

74 

Chen Y, Qiu F, Huang L, Liu W, Li L, Ji C, Zeng X, Qiao L, Liu M and Gong X: Long non-coding RNA LINC00312 regulates breast cancer progression through the miR-9/CDH1 axis. Mol Med Rep. 21:1296–1303. 2020.PubMed/NCBI View Article : Google Scholar

75 

Wu J, Zhou X, Fan Y, Cheng X, Lu B and Chen Z: Long non-coding RNA 00312 downregulates cyclin B1 and inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo. Biochem Biophys Res Commun. 497:173–180. 2018.PubMed/NCBI View Article : Google Scholar

76 

Brooks SC, Locke ER and Soule HD: Estrogen receptor in a human cell line (MCF-7) from breast carcinoma. J Biol Chem. 248:6251–6253. 1973.PubMed/NCBI

77 

Judge SM and Chatterton RT Jr: Progesterone-specific stimulation of triglyceride biosynthesis in a breast cancer cell line (T-47D). Cancer Res. 43:4407–4412. 1983.PubMed/NCBI

78 

Lasfargues EY, Coutinho WG and Redfield ES: Isolation of two human tumor epithelial cell lines from solid breast carcinomas. J Natl Cancer Inst. 61:967–978. 1978.PubMed/NCBI

79 

Brinkley BR, Beall PT, Wible LJ, Mace ML, Turner DS and Cailleau RM: Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. Cancer Res. 40:3118–3129. 1980.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Asberger J, Ge I, Schmidt B, Jäger M, Weiss D, Berner K, Erbes T, Juhasz-Böss I and Mayer S: Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?. Exp Ther Med 29: 54, 2025.
APA
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K. ... Mayer, S. (2025). Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?. Experimental and Therapeutic Medicine, 29, 54. https://doi.org/10.3892/etm.2025.12804
MLA
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K., Erbes, T., Juhasz-Böss, I., Mayer, S."Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?". Experimental and Therapeutic Medicine 29.3 (2025): 54.
Chicago
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K., Erbes, T., Juhasz-Böss, I., Mayer, S."Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?". Experimental and Therapeutic Medicine 29, no. 3 (2025): 54. https://doi.org/10.3892/etm.2025.12804
Copy and paste a formatted citation
x
Spandidos Publications style
Asberger J, Ge I, Schmidt B, Jäger M, Weiss D, Berner K, Erbes T, Juhasz-Böss I and Mayer S: Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?. Exp Ther Med 29: 54, 2025.
APA
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K. ... Mayer, S. (2025). Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?. Experimental and Therapeutic Medicine, 29, 54. https://doi.org/10.3892/etm.2025.12804
MLA
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K., Erbes, T., Juhasz-Böss, I., Mayer, S."Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?". Experimental and Therapeutic Medicine 29.3 (2025): 54.
Chicago
Asberger, J., Ge, I., Schmidt, B., Jäger, M., Weiss, D., Berner, K., Erbes, T., Juhasz-Böss, I., Mayer, S."Long non‑coding RNA signatures in breast cancer: Properties as biomarkers?". Experimental and Therapeutic Medicine 29, no. 3 (2025): 54. https://doi.org/10.3892/etm.2025.12804
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team