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Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review)

  • Authors:
    • Rui Gong
    • Jin-Lang Tan
    • Gang Liu
    • Xiao-Fang Liu
    • Le Ma
    • Shuai Shi
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation of Chinese Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Acupuncture, Moxibustion and Tuina, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
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    Published online on: January 29, 2025
       https://doi.org/10.3892/etm.2025.12811
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Abstract

The present study focused on the mechanisms of post‑ischemic stroke (IS) angiogenesis from the perspective of endothelial cells (ECs) dysfunction. First, it emphasized the importance of hypoxia‑inducible factor‑1α in the function of ECs under hypoxic conditions, particularly in promoting angiogenesis and improving cerebral blood supply. Secondly, inflammatory cytokines and adhesion factors (for example, selectins, the immunoglobulin superfamily and integrins) influence the function and angiogenesis of ECs through various mechanisms and signaling pathways following IS. In addition, the effects of oxidative stress on ECs function and angiogenesis were explored, along with the potential of antioxidant strategies to improve EC function and promote angiogenesis. Based on these insights, the present study proposed new therapeutic strategies to ameliorate endothelial dysfunction and promote angiogenesis following IS, including small‑molecule drugs targeting specific molecules, gene therapy and traditional Chinese medicine treatments. Finally, the importance of translating these laboratory findings into clinical applications was emphasized, alongside the need for advanced imaging techniques to monitor the dynamic processes of post‑IS angiogenesis and evaluate the efficacy of novel therapeutic interventions. These explorations aimed at providing a more comprehensive understanding of EC function and the regulatory mechanisms of a deeper understanding of angiogenesis following IS, offering new intervention strategies for IS treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Gong R, Tan J, Liu G, Liu X, Ma L and Shi S: Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review). Exp Ther Med 29: 61, 2025.
APA
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., & Shi, S. (2025). Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review). Experimental and Therapeutic Medicine, 29, 61. https://doi.org/10.3892/etm.2025.12811
MLA
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., Shi, S."Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review)". Experimental and Therapeutic Medicine 29.4 (2025): 61.
Chicago
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., Shi, S."Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review)". Experimental and Therapeutic Medicine 29, no. 4 (2025): 61. https://doi.org/10.3892/etm.2025.12811
Copy and paste a formatted citation
x
Spandidos Publications style
Gong R, Tan J, Liu G, Liu X, Ma L and Shi S: Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review). Exp Ther Med 29: 61, 2025.
APA
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., & Shi, S. (2025). Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review). Experimental and Therapeutic Medicine, 29, 61. https://doi.org/10.3892/etm.2025.12811
MLA
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., Shi, S."Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review)". Experimental and Therapeutic Medicine 29.4 (2025): 61.
Chicago
Gong, R., Tan, J., Liu, G., Liu, X., Ma, L., Shi, S."Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review)". Experimental and Therapeutic Medicine 29, no. 4 (2025): 61. https://doi.org/10.3892/etm.2025.12811
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