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Case Report Open Access

Diagnosis and management of oesophageal granular cell tumour: A case report

  • Authors:
    • Rui Jian
    • Yanqing Shi
    • Ting Li
    • Nanhao Zhou
    • Xijin Wang
    • Shan Li
  • View Affiliations / Copyright

    Affiliations: Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences, Jiujiang University, Jiujiang, Jiangxi 332005, P.R. China, Department of Gastroenterology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332005, P.R. China, Department of Pathology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332005, P.R. China
    Copyright: © Jian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 92
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    Published online on: March 11, 2025
       https://doi.org/10.3892/etm.2025.12842
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Abstract

Granular cell tumours (GCTs) are rare and typically benign neoplasms that can arise in various parts of the body, including the oesophagus. These tumours are considered to originate from Schwann cells and are characterized by their granular cytoplasm. Oesophageal GCTs (EGCTs) are particularly uncommon and often present with non‑specific symptoms, making their diagnosis challenging. The present case report documents the case of a 68‑year‑old male patient who was admitted to the Affiliated Hospital of Jiujiang University (Jiujiang, China) after the incidental discovery of a submucosal oesophageal mass during a routine health examination. Upon diagnostic evaluation, including endoscopy and histopathological analysis, an EGCT was identified. Endoscopic ultrasonography revealed submucosal protrusion of the lower oesophagus, where endoscopic submucosal dissection (ESD) was subsequently performed. Histopathological staining and immunohistochemistry (IHC) indicated the presence of a GCT with positivity for S‑100. The patient successfully underwent ESD without any complications. Although EGCTs are typically benign, they have the potential for malignant transformation and therefore require careful evaluation. The present case highlights the importance of differentiating EGCTs from other submucosal oesophageal lesions through histological and IHC methods. In particular, early detection and appropriate management are crucial for optimal patient outcomes. In conclusion, EGCT is a rare entity with a generally favourable prognosis when detected early. The present case underscores the importance of considering EGCTs in the differential diagnosis of oesophageal submucosal lesions and outlines the role of endoscopic and histopathological evaluation in their management.
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Copy and paste a formatted citation
Spandidos Publications style
Jian R, Shi Y, Li T, Zhou N, Wang X and Li S: Diagnosis and management of oesophageal granular cell tumour: A case report. Exp Ther Med 29: 92, 2025.
APA
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., & Li, S. (2025). Diagnosis and management of oesophageal granular cell tumour: A case report. Experimental and Therapeutic Medicine, 29, 92. https://doi.org/10.3892/etm.2025.12842
MLA
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., Li, S."Diagnosis and management of oesophageal granular cell tumour: A case report". Experimental and Therapeutic Medicine 29.5 (2025): 92.
Chicago
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., Li, S."Diagnosis and management of oesophageal granular cell tumour: A case report". Experimental and Therapeutic Medicine 29, no. 5 (2025): 92. https://doi.org/10.3892/etm.2025.12842
Copy and paste a formatted citation
x
Spandidos Publications style
Jian R, Shi Y, Li T, Zhou N, Wang X and Li S: Diagnosis and management of oesophageal granular cell tumour: A case report. Exp Ther Med 29: 92, 2025.
APA
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., & Li, S. (2025). Diagnosis and management of oesophageal granular cell tumour: A case report. Experimental and Therapeutic Medicine, 29, 92. https://doi.org/10.3892/etm.2025.12842
MLA
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., Li, S."Diagnosis and management of oesophageal granular cell tumour: A case report". Experimental and Therapeutic Medicine 29.5 (2025): 92.
Chicago
Jian, R., Shi, Y., Li, T., Zhou, N., Wang, X., Li, S."Diagnosis and management of oesophageal granular cell tumour: A case report". Experimental and Therapeutic Medicine 29, no. 5 (2025): 92. https://doi.org/10.3892/etm.2025.12842
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