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Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis

  • Authors:
    • Siqi Xie
    • Chonghe Xu
    • Zhongqi Zhu
    • Chao Qin
    • Xixi Song
    • Xin Wang
    • Wei Xu
    • Mei Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The Affiliated Chaohu Hospital of Anhui Medical University, Chaohu, Anhui 238000, P.R. China, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China, Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 99
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    Published online on: March 19, 2025
       https://doi.org/10.3892/etm.2025.12849
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Abstract

Kidney transplantation remains the preferred treatment for patients with end‑stage kidney failure. Complement‑dependent cytotoxicity (CDC) crossmatch (CDC‑XM) and human leukocyte antigen (HLA) typing are two important methods of donor‑recipient matching prior to kidney transplantation. The purpose of the present study was to explore the effects of CDC‑XM levels and HLA matching on early post‑operative clinical outcomes in kidney transplant recipients. A total of 112 consecutive recipients who underwent allogeneic kidney transplantation were selected and their data collected, including pre‑operative general information, indicators associated with renal function, red blood cell and white blood cell counts, the blood glucose level at each follow‑up time point and both the incidence of adverse events following transplantation and their risk factors. During the follow‑up period, statistical methods were used to compare and systematically analyze the differences in clinical indicators and adverse events between each groups. In each different groups that were assigned for the CDC‑XM levels and HLA matching, the differences in the clinical indicators between the groups during the follow‑up period were mainly centered on the first week post‑transplantation, with the greatest differences being identified for the renal function‑associated indicators, whereas the observed recovery was essentially comparable between 1‑6 months. According to the multivariate analysis, recipients of age ≥40 years and with a BMI ≥25 tended to have an increased risk of delayed graft function (DGF), whereas the risk was reduced when the organ had been donated by a living donor and also when the number of HLA mismatches was 0‑2. In conclusion, the present study showed that CDC‑negativity and improved HLA matching help to promote the recovery of renal function in kidney transplant recipients during the early post‑operative period. Patients who met the conditions of CDC‑negativity and fewer HLA mismatches had faster and improved early postoperative recovery of renal function and a lower incidence of DGF. Furthermore, in a multifactorial analysis of DGF, recipient age, recipient BMI, donor type and HLA mismatch were found to be important risk factors for DGF.
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Copy and paste a formatted citation
Spandidos Publications style
Xie S, Xu C, Zhu Z, Qin C, Song X, Wang X, Xu W and Zhu M: Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis. Exp Ther Med 29: 99, 2025.
APA
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X. ... Zhu, M. (2025). Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis. Experimental and Therapeutic Medicine, 29, 99. https://doi.org/10.3892/etm.2025.12849
MLA
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X., Xu, W., Zhu, M."Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis". Experimental and Therapeutic Medicine 29.5 (2025): 99.
Chicago
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X., Xu, W., Zhu, M."Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis". Experimental and Therapeutic Medicine 29, no. 5 (2025): 99. https://doi.org/10.3892/etm.2025.12849
Copy and paste a formatted citation
x
Spandidos Publications style
Xie S, Xu C, Zhu Z, Qin C, Song X, Wang X, Xu W and Zhu M: Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis. Exp Ther Med 29: 99, 2025.
APA
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X. ... Zhu, M. (2025). Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis. Experimental and Therapeutic Medicine, 29, 99. https://doi.org/10.3892/etm.2025.12849
MLA
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X., Xu, W., Zhu, M."Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis". Experimental and Therapeutic Medicine 29.5 (2025): 99.
Chicago
Xie, S., Xu, C., Zhu, Z., Qin, C., Song, X., Wang, X., Xu, W., Zhu, M."Influence of CDC‑XM and HLA compatibility on clinical outcomes in kidney transplant recipients during the post‑operative recovery period: A retrospective analysis". Experimental and Therapeutic Medicine 29, no. 5 (2025): 99. https://doi.org/10.3892/etm.2025.12849
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