1
|
Block E: The chemistry of garlic and
onions. Sci Am. 252:114–119. 1985.PubMed/NCBI View Article : Google Scholar
|
2
|
Ahmed T and Wang CK: Black garlic and its
bioactive compounds on human health diseases: A review. Molecules.
26(5028)2021.PubMed/NCBI View Article : Google Scholar
|
3
|
Kodera Y, Kurita M, Nakamoto M and
Matsutomo T: Chemistry of aged garlic: Diversity of constituents in
aged garlic extract and their production mechanisms via the
combination of chemical and enzymatic reactions. Exp Ther Med.
19:1574–1584. 2020.PubMed/NCBI View Article : Google Scholar
|
4
|
Takemura S, Ihara H, Nakagawa K and
Minamiyama Y: S-allyl cysteine blood flow in NO-dependent
and -independent manners. Glycative Stress Research. 9:146–157.
2022.
|
5
|
Nakagawa S, Masamoto K, Sumiyoshi H and
Harada H: Acute toxicity test of garlic extract. J Toxicol Sci.
9:57–60. 1984.PubMed/NCBI View Article : Google Scholar : (In Japanese).
|
6
|
Sumiyoshi H, Kanezawa A, Masamoto K,
Harada H, Nakagami S, Yokota A, Nishikawa M and Nakagawa S: Chronic
toxicity test of garlic extract in rat. J Toxicol Sci. 9:61–75.
1984.PubMed/NCBI View Article : Google Scholar : (In Japanese).
|
7
|
Yoshida S, Hirano Y and Nakagawa S:
Mutagenicity and cytotoxicity tests of garlic. J Toxicol Sci.
9:77–86. 1984.PubMed/NCBI View Article : Google Scholar : (In Japanese).
|
8
|
Syu JN, Yang MD, Tsai SY, Chiang EI, Chiu
SC, Chao CY, Rodriguez RL and Tang FY: S-allylcysteine
improves blood flow recovery and prevents ischemic injury by
augmenting neovasculogenesis. Cell Transplant. 26:1636–1647.
2017.PubMed/NCBI View Article : Google Scholar
|
9
|
Chao WW, Chen YK, Chao HW, Pan WH and Chao
HM: Fortified S-Allyl L-Cysteine: Animal safety, effect on
retinal ischemia, and role of wnt in the underlying therapeutic
mechanism. Evid Based Complement Alternat Med.
2020(3025946)2020.PubMed/NCBI View Article : Google Scholar
|
10
|
Chao WW, Chao HW, Lee HF and Chao HM: The
effect of S-Allyl L-Cysteine on retinal ischemia: The
contributions of MCP-1 and PKM2 in the underlying medicinal
properties. Int J Mol Sci. 25(1349)2024.PubMed/NCBI View Article : Google Scholar
|
11
|
Shin NR, Kwon HJ, Ko JW, Kim JS, Lee IC,
Kim JC, Kim SH and Skin IS: S-Allyl cysteine reduces
eosinophilic airway inflammation and mucus overproduction on
ovalbumin-induced allergic asthma model. Int Immunopharmacol.
68:124–130. 2019.PubMed/NCBI View Article : Google Scholar
|
12
|
Nango H and Ohtani M:
S-1-propenyl-L-cysteine suppresses
lipopolysaccharide-induced expression of matrix metalloproteinase-1
through inhibition of tumor necrosis factor-α converting
enzyme-epidermal growth factor receptor axis in human gingival
fibroblasts. PLoS One. 18(e0284713)2023.PubMed/NCBI View Article : Google Scholar
|
13
|
Ushijima M, Takashima M, Kunimura K,
Kodera Y, Morihara N and Tamura K: Effects of
S-1-propenylcysteine, a sulfur compound in aged garlic
extract, on blood pressure and peripheral circulation in
spontaneously hypertensive rats. J Pharm Pharmacol. 70:559–565.
2018.PubMed/NCBI View Article : Google Scholar
|
14
|
Matsutomo T, Ushijima M, Kodera Y,
Nakamoto M, Takashima M, Morihara N and Tamura K: Metabolomic study
on the antihypertensive effect of S-1-propenylcysteine in
spontaneously hypertensive rats using liquid chromatography coupled
with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt
Technol Biomed Life Sci. 1046:147–155. 2017.PubMed/NCBI View Article : Google Scholar
|
15
|
Matsutomo T, Ushijima M, Kunimura K and
Ohtani M: Metabolomic study reveals the acute hypotensive effect of
S-1-propenylcysteine accompanied by alteration of the plasma
histidine level in spontaneously hypertensive rats. J Pharm Biomed
Anal. 168:148–154. 2019.PubMed/NCBI View Article : Google Scholar
|
16
|
Miki S, Suzuki J, Takashima M, Ishida M,
Kokubo H and Yoshizumi M: S-1-Propenylcysteine promotes
IL-10-induced M2c macrophage polarization through prolonged
activation of IL-10R/STAT3 signaling. Sci Rep.
11(22469)2021.PubMed/NCBI View Article : Google Scholar
|
17
|
Nishikawa-Ogawa M, Wanibuchi H, Morimura
K, Kinoshita A, Nishikawa T, Hyashi S, Yano Y and Fukushima S:
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat
hepatocarcinogenesis in the post-initiation stage. Carcinogenesis.
27:982–988. 2006.PubMed/NCBI View Article : Google Scholar
|
18
|
Hsu CC, Yen HF, Yin MC, Tsai CM and Hsieh
CH: Five cysteine-containing compounds delay diabetic deterioration
in Balb/cA mice. J Nutr. 134:3245–3249. 2004.PubMed/NCBI View Article : Google Scholar
|
19
|
Wassef R, Haenold R, Hansel A, Brot N,
Heinemann SH and Hoshi T: Methionine sulfoxide reductase A and a
dietary supplement S-methyl-L-cysteine prevent
Parkinson's-like symptoms. J Neurosci. 27:12808–12816.
2007.PubMed/NCBI View Article : Google Scholar
|
20
|
Yang G, Li S, Li B, Cheng L, Jiang P, Tian
Z and Sun S: Protective effects of garlic-derived
S-Allylmercaptocysteine on IL-1 β-stimulated chondrocytes by
regulation of MMPs/TIMP-1 ratio and type II collagen expression via
suppression of NF-κB pathway. Biomed Res Int.
2017(8686207)2017.PubMed/NCBI View Article : Google Scholar
|
21
|
Zhang Y, Li HY, Zhang ZH, Bian HL and Lin
G: Garlic-derived compound S-allylmercaptocysteine inhibits
cell growth and induces apoptosis via the JNK and p38 pathways in
human colorectal carcinoma cells. Oncol Lett. 8:2591–2596.
2014.PubMed/NCBI View Article : Google Scholar
|
22
|
Sumioka I, Matsura T, Kasuga S, Itakura Y
and Yamada K: Mechanisms of protection by
S-allylmercaptocysteine against acetaminophen-induced liver
injury in mice. Jpn J Pharmacol. 78:199–207. 1998.PubMed/NCBI View Article : Google Scholar
|
23
|
Zhu X, Jiang X, Li A, Zhao Z and Li S:
S-Allylmercaptocysteine attenuates cisplatin-induced
nephrotoxicity through suppression of apoptosis, oxidative stress,
and inflammation. Nutrients. 9(166)2017.PubMed/NCBI View Article : Google Scholar
|
24
|
Nagae S, Ushijima M, Hatono S, Imai J,
Kasuga S, Matsuura H, Itakura Y and Higashi Y: Pharmacokinetics of
the garlic compound S-allylcysteine. Plant Med. 60:214–217.
1994.PubMed/NCBI View Article : Google Scholar
|
25
|
Amano H, Kazamori D, Itoh K and Kodera Y:
Metabolism, excretion, and pharmacokinetics of
S-allyl-L-cysteine in rats and dogs. Drug Metab Dispos.
43:749–755. 2015.PubMed/NCBI View Article : Google Scholar
|
26
|
Park T, Oh JH, Park SC, Jang YP and Lee
YJ: Oral administration of (S)-Allyl-L-Cysteine and aged
garlic extract to rats: Determination of metabolites and their
pharmacokinetics. Plant Med. 83:1351–1360. 2017.PubMed/NCBI View Article : Google Scholar
|
27
|
Kodera Y, Suzuki A, Imada O, Kasuga S,
Sumioka I, Kanezawa A, Taru N, Fujikawa M, Nagae S, Masamoto K, et
al: Physical, chemical, and biological properties of
S-Allylcysteine, an amino acid derived from garlic. J Agric Food
Chem. 50:622–632. 2002.PubMed/NCBI View Article : Google Scholar
|
28
|
Amano H, Kazamori D and Itoh K:
Pharmacokinetics and N-acetylation metabolism of
S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and
dogs. Xenobiotica. 46:1017–1025. 2016.PubMed/NCBI View Article : Google Scholar
|
29
|
Sklan NM and Barnsley EA: The metabolism
of S-methyl-L-cysteine. Biochem J. 107:217–223.
1968.PubMed/NCBI View Article : Google Scholar
|
30
|
Mitchell SC, Smith RL, Waring RH and
Aldington GF: The metabolism of S-methyl-L-cysteine in man.
Xenobiotica. 14:767–779. 1984.PubMed/NCBI View Article : Google Scholar
|
31
|
Yang M, Dong Z, Jiang X, Zhao Z, Zhang J,
Cao X and Zhang D: Determination of S-Allylmercaptocysteine
in Rat Plasma by LC-MS/MS and its application to a pharmacokinetics
study. J Chromatogr Sci. 56:396–402. 2018.PubMed/NCBI View Article : Google Scholar
|
32
|
Nakamoto M and Kunimura K: Study of the
metabolism of S-allylmercaptocysteine to elucidate its
metabolites and metabolic pathway in rats. Eur Food Res Technol.
249:1377–1389. 2023.
|
33
|
Tsao SM and Yin M: In-vitro antimicrobial
activity of four diallyl sulphides occurring naturally in garlic
and Chinese leek oils. J Med Microbiol. 50:646–649. 2001.PubMed/NCBI View Article : Google Scholar
|
34
|
Lai KC, Hsu SC, Kuo CL, Yang JS, Ma CY, Lu
HF, Tang NY, Hsia TC, Ho HC and Chung JG: Diallyl sulfide, diallyl
disulfide, and diallyl trisulfide inhibit migration and invasion in
human colon cancer colo 205 cells through the inhibition of matrix
metalloproteinase-2, -7, and -9 expressions. Environ Toxicol.
28:479–488. 2013.PubMed/NCBI View Article : Google Scholar
|
35
|
Yu T, Wang Q, Li XJ, Li M, Liu ND and Xie
KQ: Antioxidant mechanism of diallyl sulfide in inhibiting
leucopenia in peripheral blood induced by benzene in rats. Zhonghua
Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 37:737–745. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).
|
36
|
Jin L and Baillie TA: Metabolism of the
chemoprotective agent diallyl sulfide to glutathione conjugates in
rats. Chem Res Toxicol. 10:318–327. 1997.PubMed/NCBI View Article : Google Scholar
|
37
|
Zheng Y, Li G, Shi A, Guo J, Xu Y and Cai
W: Role of miR-455-3p in the alleviation of LPS-induced acute lung
injury by allicin. Heliyon. 10(e39338)2024.PubMed/NCBI View Article : Google Scholar
|
38
|
Gan L, Geng L, Li Q, Zhang L, Huang Y, Lin
J and Ou S: Allicin ameliorated high-glucose peritoneal dialysis
solution-induced peritoneal fibrosis in rats via the JAK2/STAT3
signaling pathway. Cell Biochem Biophys: Oct 25, 2024 (Epub ahead
of print).
|
39
|
Liu S, He Y, Shi J, Liu L, Ma H, He L and
Guo Y: Allicin attenuates myocardial ischmia reperfusion injury in
rats by inhibition of inflammation and oxidative stress. Transplant
Proc. 51:2060–2065. 2019.PubMed/NCBI View Article : Google Scholar
|
40
|
Lachmann G, Lorenz D, Radeck W and Steiper
M: The pharmacokinetics of the S35 labeled labeled garlic
constituents alliin, allicin and vinyldithiine.
Arzneimittelforschung. 44:734–743. 1994.PubMed/NCBI(In German).
|
41
|
Freeman F and Kodera Y: Garlic chemistry:
Stability of S-(2-propyl)-2-propen-1-sulfinothioate
(allicin) in blood, solvents, and stimulated physiological fluids.
J Agric Food Chem. 43:2332–2338. 1995.
|
42
|
Keophiphath M, Priem F, Jacquemond-Collet
I, Clément K and Lacasa D: 1,2-vinyldithiin from garlic inhibits
differentiation and inflammation of human preadipocytes. J Nur.
139:2055–2060. 2009.PubMed/NCBI View Article : Google Scholar
|
43
|
Jiang C, Huang H, Zhong C, Feng S, Wang C,
Xue H and Zhang J: Alliin mitigates the acute kidney injury by
suppressing ferroptosis via regulating the Nrf2/GPX4 axis. Naunyn
Schmiedebergs Arch Pharmacol. 398:1521–1533. 2025.PubMed/NCBI View Article : Google Scholar
|
44
|
Zhang M, Zou X, Du Y, Pan Z, He F, Sun Y
and Li M: Integrated transcriptomics and metabolomics reveal the
mecanism of alliin in improving hyperlipidemia. Foods Sep.
12(3407)2023.PubMed/NCBI View Article : Google Scholar
|
45
|
Liu M, Lu J, Yang S, Chen Y, Yu J and Guan
S: Alliin alleviates LPS-induced pyroptosis via promoting mitophagy
in THP-1 macrophages and mice. Food Chem Toxicol.
160(112811)2022.PubMed/NCBI View Article : Google Scholar
|
46
|
Agarwal RK, Dewar HA, Newell DJ and Das B:
Controlled trial of the effect of cycloalliin on the fibrinolytic
activity of venous blood. Atherosclerosis. 27:347–351.
1977.PubMed/NCBI View Article : Google Scholar
|
47
|
Yoshinari O, Shiojima Y and Igarashi K:
Anti-obesity effects of onion extract in Zucker diabetic fatty
rats. Nutrients. 4:1518–1526. 2012.PubMed/NCBI View Article : Google Scholar
|
48
|
Yanagita T, Han SY, Wang YM, Tsuruta Y and
Anno T: Cycloalliin, a cyclic sulfur imino acid, reduces serum
triacylglycerol in rats. Nutrition. 19:140–143. 2003.PubMed/NCBI View Article : Google Scholar
|
49
|
Ichikawa M, Mizuno I, Yoshida J, Ide N,
Ushijima M, Kodera Y, Hayama M and Ono K: Pharmacokinetics of
cycloalliin, an organosulfur compound found in garlic and onion, in
rats. J Agric Food Chem. 54:9811–9819. 2006.PubMed/NCBI View Article : Google Scholar
|