Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 29 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report

  • Authors:
    • Alperen Sozer
    • Mesut Emre Yaman
    • Hakan Emmez
    • Aydemir Kale
    • Efe Guner
    • Halise Devrimci Ozguven
    • Ali Savas
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Gazi University Faculty of Medicine, 06560 Ankara, Türkiye, Department of Neurosurgery, Guven Hospital, 06540 Ankara, Türkiye, Department of Neurosurgery, Ankara University School of Medicine, 06230 Ankara, Türkiye, Department of Psychiatry, Ankara University School of Medicine, 06230 Ankara, Türkiye
  • Article Number: 120
    |
    Published online on: April 16, 2025
       https://doi.org/10.3892/etm.2025.12870
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Central lesioning techniques, such as cingulotomy and capsulotomy, have demonstrated efficacy in managing chronic pain, particularly in complex cases. These procedures are particularly useful for patients who are non‑responsive to conventional treatments. The current study presents, to the best of our knowledge, the first case of a patient received combined stereotactic radiofrequency (RF) cingulotomy and GammaKnife capsulotomy (GKC), and who achieved good pain control after. The patient initially presented with severe, continuous left‑sided facial pain unresponsive to medication and subsequently underwent a bilateral stereotactic RF cingulotomy. Pain levels were monitored using the Numeric Rating Scale. Patient satisfaction, as well as neurological and cognitive functions, were evaluated over a 2‑year period. At 1‑month post‑cingulotomy, the patient's pain reduced from the initial score of 9/10 to 1/10, and the patient remained pain‑free for the subsequent 3 months. Upon recurrence, the conducted GKC resulted in a more sustained reduction of pain to 2‑3/10 at 1‑year post‑procedure. The patient reported high satisfaction with no observed neurological or cognitive deficits. Magnetic resonance imaging scans confirmed the presence of capsulotomy lesions in addition to the existing cingulotomy lesions. The combined cingulotomy and capsulotomy approach provided significant and sustained pain relief in the patient, indicating the potential of these techniques as advanced treatment options for refractory trigeminal neuropathic pain. This case is the first documented instance of the combined use of cingulotomy and capsulotomy, suggesting their viability for patients requiring higher‑tier pain management strategies.
View Figures

Figure 1

Figure 2

View References

1 

Farrell SM, Pereira EAC, Brown MRD, Green AL and Aziz TZ: Neuroablative surgical treatments for pain due to cancer. Neurochirurgie. 67:176–188. 2021.PubMed/NCBI View Article : Google Scholar

2 

Deng Z, Pan Y, Li D, Zhang C, Jin H, Wang T, Zhan S and Sun B: Effect of bilateral anterior cingulotomy on chronic neuropathic pain with severe depression. World Neurosurg. 121:196–200. 2019.PubMed/NCBI View Article : Google Scholar

3 

Sharim J and Pouratian N: Anterior cingulotomy for the treatment of chronic intractable pain: A systematic review. Pain Physician. 19:537–550. 2016.PubMed/NCBI

4 

Allam AK, Larkin Michael MB, Shofty B and Viswanathan A: Ablation procedures. Neurosurg Clin N Am. 33:339–344. 2022.PubMed/NCBI View Article : Google Scholar

5 

Viswanathan A, Harsh V, Pereira EAC and Aziz TZ: Cingulotomy for medically refractory cancer pain. Neurosurg Focus. 35(E1)2013.PubMed/NCBI View Article : Google Scholar

6 

Kollenburg L, Kurt E, Arnts H and Vinke S: Cingulotomy: The last man standing in the battle against medically refractory poststroke pain. Pain Rep. 9(e1149)2024.PubMed/NCBI View Article : Google Scholar

7 

Doshi PK: Anterior capsulotomy for refractory OCD: First case as per the core group guidelines. Indian J Psychiatry. 53:270–273. 2011.PubMed/NCBI View Article : Google Scholar

8 

Lozano AM, Gildenberg PL and Tasker RR: Textbook of Stereotactic and Functional Neurosurgery. In: Medicine, Reference Module Medicine. 2nd edition. Springer, Heidelberg, 2009.

9 

Yen CP, Kung SS, Su YF, Lin WC, Howng SL and Kwan AL: Stereotactic bilateral anterior cingulotomy for intractable pain. J Clin Neurosci. 12:886–890. 2005.PubMed/NCBI View Article : Google Scholar

10 

Talbot JD, Villemure JG, Bushnell MC and Duncan GH: Evaluation of pain perception after anterior capsulotomy: A case report. Somatosens Mot Res. 12:115–126. 1995.PubMed/NCBI View Article : Google Scholar

11 

He W, Shao L, Wang H, Huang H, Zhang S, Li C, Zhang C and Yi W: Bilateral anterior capsulotomy for the treatment of refractory somatic symptom disorder: A case report. Front Integr Neurosci. 15(721833)2022.PubMed/NCBI View Article : Google Scholar

12 

Davis KD, Hutchison WD, Lozano AM and Dostrovsky JO: Altered pain and temperature perception following cingulotomy and capsulotomy in a patient with schizoaffective disorder. Pain. 59:189–199. 1994.PubMed/NCBI View Article : Google Scholar

13 

Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, Hals EK, Kvarstein G and Stubhaug A: Assessment of pain. Br J Anaesth. 101:17–24. 2008.PubMed/NCBI View Article : Google Scholar

14 

Rogers CL, Shetter AG, Fiedler JA, Smith KA, Han PP and Speiser BL: Gamma knife radiosurgery for trigeminal neuralgia: The initial experience of the Barrow Neurological Institute. Int J Radiat Oncol Biol Phys. 47:1013–1019. 2000.PubMed/NCBI View Article : Google Scholar

15 

Hassenbusch SJ, Pillay PK and Barnett GH: Radiofrequency cingulotomy for intractable cancer pain using stereotaxis guided by magnetic resonance imaging. Neurosurgery. 27:220–223. 1990.PubMed/NCBI View Article : Google Scholar

16 

Guner YE, Comert A, Sayaci EY, Korkmaz AC, Gungor Y, Morali Guler T, Kahilogullari G and Savas A: Microsurgical anatomy of the anterior cerebral artery and the arterial supply of the cingulate gyrus. Surg Radiol Anat. 45:351–358. 2023.PubMed/NCBI View Article : Google Scholar

17 

Fedorov A, Beichel R, Kalpathy-Cramer J, Finet J, Fillion-Robin JC, Pujol S, Bauer C, Jennings D, Fennessy F, Sonka M, et al: 3D Slicer as an image computing platform for the quantitative imaging network. Magn Reson Imaging. 30:1323–1341. 2012.PubMed/NCBI View Article : Google Scholar

18 

Pinter C, Lasso A, Wang A, Jaffray D and Fichtinger G: SlicerRT: Radiation therapy research toolkit for 3D Slicer. Med Phys. 39:6332–6338. 2012.PubMed/NCBI View Article : Google Scholar

19 

Araya EI, Claudino RF, Piovesan EJ and Chichorro JG: Trigeminal neuralgia: Basic and clinical aspects. Curr Neuropharmacol. 18:109–119. 2020.PubMed/NCBI View Article : Google Scholar

20 

Kanpolat Y, Kahilogullari G, Ugur HC and Elhan AH: Computed tomography-guided percutaneous trigeminal tractotomy-nucleotomy. Neurosurgery. 63 (Suppl 1):ONS147–ONS155. 2008.PubMed/NCBI View Article : Google Scholar

21 

Singleton WGB, Ashida R and Patel NK: Deep Brain Stimulation for Facial Pain. In: Neuromodulation for facial pain. Slavin KV (ed). Progress in Neurological Surgery, pp141-161, 2020.

22 

Burchiel KJ: A new classification for facial pain. Neurosurgery. 53:1164–1167. 2003.PubMed/NCBI View Article : Google Scholar

23 

Murugappan SK, Hasan M, Lei Z, Iqbal Z, Ramkrishnan AS, Wong HY and Li Y: Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision-making in male rats. J Neurosci Res. 99:2721–2742. 2021.PubMed/NCBI View Article : Google Scholar

24 

Boccard SGJ, Prangnell SJ, Pycroft L, Cheeran B, Moir L, Pereira EAC, Fitzgerald JJ, Green AL and Aziz TZ: Long-term results of deep brain stimulation of the anterior cingulate cortex for neuropathic pain. World Neurosurg. 106:625–637. 2017.PubMed/NCBI View Article : Google Scholar

25 

Chung M and Huh R: Neuromodulation for trigeminal neuralgia. J Korean Neurosurg Soc. 65:640–651. 2022.PubMed/NCBI View Article : Google Scholar

26 

Lempka SF, Malone DA Jr, Hu B, Baker KB, Wyant A, Ozinga JG IV, Plow EB, Pandya M, Kubu CS, Ford PJ and Machado AG: Randomized clinical trial of deep brain stimulation for poststroke pain. Ann Neurol. 81:653–663. 2017.PubMed/NCBI View Article : Google Scholar

27 

Marques RAS, Alencar HS, Bannach MA and Vilela-Filho O: Semidirect targeting-based stereotactic mesencephalotomy for the treatment of refractory pain: a case series. J Neurosurg. 136:1128–1138. 2021.PubMed/NCBI View Article : Google Scholar

28 

Burchiel KJ, Steege TD, Howe JF and Loeser JD: Comparison of percutaneous radiofrequency gangliolysis and microvascular decompression for the surgical management of tic douloureux. Neurosurgery. 9:111–119. 1981.PubMed/NCBI View Article : Google Scholar

29 

Sadashiva N, Tripathi M and De Salles A: Contemporary role of stereotactic radiosurgery for psychiatric disorders. Neurol India. 71 (Suppl 1):S31–S38. 2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sozer A, Yaman ME, Emmez H, Kale A, Guner E, Ozguven HD and Savas A: Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report. Exp Ther Med 29: 120, 2025.
APA
Sozer, A., Yaman, M.E., Emmez, H., Kale, A., Guner, E., Ozguven, H.D., & Savas, A. (2025). Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report. Experimental and Therapeutic Medicine, 29, 120. https://doi.org/10.3892/etm.2025.12870
MLA
Sozer, A., Yaman, M. E., Emmez, H., Kale, A., Guner, E., Ozguven, H. D., Savas, A."Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 120.
Chicago
Sozer, A., Yaman, M. E., Emmez, H., Kale, A., Guner, E., Ozguven, H. D., Savas, A."Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 120. https://doi.org/10.3892/etm.2025.12870
Copy and paste a formatted citation
x
Spandidos Publications style
Sozer A, Yaman ME, Emmez H, Kale A, Guner E, Ozguven HD and Savas A: Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report. Exp Ther Med 29: 120, 2025.
APA
Sozer, A., Yaman, M.E., Emmez, H., Kale, A., Guner, E., Ozguven, H.D., & Savas, A. (2025). Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report. Experimental and Therapeutic Medicine, 29, 120. https://doi.org/10.3892/etm.2025.12870
MLA
Sozer, A., Yaman, M. E., Emmez, H., Kale, A., Guner, E., Ozguven, H. D., Savas, A."Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 120.
Chicago
Sozer, A., Yaman, M. E., Emmez, H., Kale, A., Guner, E., Ozguven, H. D., Savas, A."Staged cingulotomy and capsulotomy for trigeminal neuropathic pain: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 120. https://doi.org/10.3892/etm.2025.12870
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team