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Case Report Open Access

Pituitary apoplexy in a patient on antiplatelet therapy: A case report

  • Authors:
    • Chuan Shao
    • Dewei Zou
    • Junwei Wang
    • Jun Lai
    • Nan Wu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Chongqing General Hospital, Chongqing University, Chongqing 401147, P.R. China
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 124
    |
    Published online on: April 24, 2025
       https://doi.org/10.3892/etm.2025.12874
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Abstract

Pituitary apoplexy is a rare but life‑threatening neurosurgical emergency, typically caused by acute hemorrhage or infarction of a pituitary adenoma within the sella turcica. It presents clinically with the sudden onset of severe headache, visual impairment and ophthalmoplegia. The present study reported the case of a 45‑year‑old male who experienced intermittent headaches and progressive right‑sided visual deterioration over two months, with acute worsening in the preceding 6 h. The patient's medical history included coronary stent implantation and the patient had been on enteric‑coated aspirin therapy for ~4 months. Magnetic resonance imaging and computed tomography of the head confirmed the diagnosis of pituitary apoplexy. The patient underwent emergency endoscopic transsphenoidal surgery, leading to significant improvement in right‑sided vision. At the 6‑month follow‑up, the patient exhibited complete recovery with no evidence of tumor recurrence on imaging. This case highlights the importance of timely diagnosis and surgical intervention in achieving favorable outcomes in pituitary apoplexy and serves as a reminder for clinicians to consider the risk of hemorrhage in patients on long‑term antiplatelet therapy.
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1 

Abbara A, Clarke S, Eng PC, Milburn J, Joshi D, Comninos AN, Ramli R, Mehta A, Jones B, Wernig F, et al: Clinical and biochemical characteristics of patients presenting with pituitary apoplexy. Endocr Connect. 7:1058–1066. 2018.PubMed/NCBI View Article : Google Scholar

2 

Briet C, Salenave S, Bonneville JF, Laws ER and Chanson P: Pituitary Apoplexy. Endocr Rev. 36:622–645. 2015.PubMed/NCBI View Article : Google Scholar

3 

Daly AF and Beckers A: The epidemiology of pituitary adenomas. Endocrinol Metab Clin North Am. 49:347–355. 2020.PubMed/NCBI View Article : Google Scholar

4 

Iglesias P: Pituitary apoplexy: An updated review. J Clin Med. 13(2508)2024.PubMed/NCBI View Article : Google Scholar

5 

Gheorghe AM, Trandafir AI, Ionovici N, Carsote M, Nistor C, Popa FL and Stanciu M: Pituitary apoplexy in patients with pituitary neuroendocrine tumors (PitNET). Biomedicines. 11(680)2023.PubMed/NCBI View Article : Google Scholar

6 

Muthukumar N: Pituitary apoplexy: A comprehensive review. Neurol India. 68 (Supplement):S72–S78. 2020.PubMed/NCBI View Article : Google Scholar

7 

Semenov A, Denoix E, Thiebaut M, Michon A and Pouchot J: Pituitary apoplexy following coronary bypass surgery: A case report and literature review. Rev Med Interne. 41:852–857. 2020.PubMed/NCBI View Article : Google Scholar : (In French).

8 

Cooper DM, Bazaral MG, Furlan AJ, Sevilla E, Ghattas MA, Sheeler LR, Little JR, Hahn JF, Sheldon WC and Loop FD: Pituitary apoplexy: A complication of cardiac surgery. Ann Thorac Surg. 41:547–550. 1986.PubMed/NCBI View Article : Google Scholar

9 

Fuchs S, Beeri R, Hasin Y, Weiss AT, Gotsman MS and Zahger D: Pituitary apoplexy as a first manifestation of pituitary adenomas following intensive thrombolytic and antithrombotic therapy. Am J Cardiol. 81:110–111. 1998.PubMed/NCBI View Article : Google Scholar

10 

Loubani M and Galiñanes M: Pituitary gland macroadenoma: A cause of transient blindness after cardiac surgery. Ann Thorac Surg. 72:929–931. 2001.PubMed/NCBI View Article : Google Scholar

11 

Mattke AF, Vender JR and Anstadt MR: Pituitary apoplexy presenting as addisonian crisis after coronary artery bypass grafting. Tex Heart Inst J. 29:193–199. 2002.PubMed/NCBI

12 

Chen Z, Murray AW and Quinlan JJ: Pituitary apoplexy presenting as unilateral third cranial nerve palsy after coronary artery bypass surgery. Anesth Analg. 98:46–48. 2004.PubMed/NCBI View Article : Google Scholar

13 

Kulikov A, Konovalov A, Pugnaloni PP and Bilotta F: Aspirin interruption before neurosurgical interventions: A controversial problem. World J Cardiol. 16:191–198. 2024.PubMed/NCBI View Article : Google Scholar

14 

Crescente M, Menke L, Chan MV, Armstrong PC and Warner TD: Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). Br J Pharmacol. 176:988–999. 2019.PubMed/NCBI View Article : Google Scholar

15 

Rajasekaran S, Vanderpump M, Baldeweg S, Drake W, Reddy N, Lanyon M, Markey A, Plant G, Powell M, Sinha S, et al: UK guidelines for the management of pituitary apoplexy. Clin Endocrinol (Oxf). 74:9–20. 2011.PubMed/NCBI View Article : Google Scholar

16 

Goshtasbi K, Abiri A, Sahyouni R, Mahboubi H, Raefsky S, Kuan EC, Hsu FPK and Cadena G: Visual and endocrine recovery following conservative and surgical treatment of pituitary apoplexy: A meta-analysis. World Neurosurg. 132:33–40. 2019.PubMed/NCBI View Article : Google Scholar

17 

Mamelak AN, Little AS, Gardner PA, Almeida JP, Recinos P, Soni P, Kshettry VR, Jane JA Jr, Barkhoudarian G, Kelly DF, et al: A prospective, multicenter, observational study of surgical vs nonsurgical management for pituitary apoplexy. J Clin Endocrinol Metab. 109:e711–e725. 2024.PubMed/NCBI View Article : Google Scholar

18 

Randeva HS, Schoebel J, Byrne J, Esiri M, Adams CB and Wass JA: Classical pituitary apoplexy: Clinical features, management and outcome. Clin Endocrinol (Oxf). 51:181–188. 1999.PubMed/NCBI View Article : Google Scholar

19 

Singh TD, Valizadeh N, Meyer FB, Atkinson JL, Erickson D and Rabinstein AA: Management and outcomes of pituitary apoplexy. J Neurosurg. 122:1450–1457. 2015.PubMed/NCBI View Article : Google Scholar

20 

Cabuk B, Kaya NS, Polat C, Geyik AM, Icli D, Anik I and Ceylan S: Outcome in pituitary apoplexy patients, stratified by delay between symptom appearance and surgery: A single center retrospective analysis. Clin Neurol Neurosurg. 210(106991)2021.PubMed/NCBI View Article : Google Scholar

21 

Paredes I, Rodríguez-Berrocal V, Pérez-López C, García-Feijoo P, Alvarez-Escola C, Acitores Cancela A, Araujo-Castro M, Calatayud M, Librizzi MS and Lagares A: Influence of surgical timing on the visual prognosis of patients suffering from a pituitary apoplexy with visual impairment. Neurosurg Rev. 47(852)2024.PubMed/NCBI View Article : Google Scholar

22 

Kelly PD, Fernando SJ, Malenke JA, Chandra RK, Turner JH and Chambless LB: The effect of timing of surgery in pituitary apoplexy on continuously valued visual acuity. J Neurol Surg B Skull Base. 82 (Suppl 3):e70–e78. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shao C, Zou D, Wang J, Lai J and Wu N: Pituitary apoplexy in a patient on antiplatelet therapy: A case report. Exp Ther Med 29: 124, 2025.
APA
Shao, C., Zou, D., Wang, J., Lai, J., & Wu, N. (2025). Pituitary apoplexy in a patient on antiplatelet therapy: A case report. Experimental and Therapeutic Medicine, 29, 124. https://doi.org/10.3892/etm.2025.12874
MLA
Shao, C., Zou, D., Wang, J., Lai, J., Wu, N."Pituitary apoplexy in a patient on antiplatelet therapy: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 124.
Chicago
Shao, C., Zou, D., Wang, J., Lai, J., Wu, N."Pituitary apoplexy in a patient on antiplatelet therapy: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 124. https://doi.org/10.3892/etm.2025.12874
Copy and paste a formatted citation
x
Spandidos Publications style
Shao C, Zou D, Wang J, Lai J and Wu N: Pituitary apoplexy in a patient on antiplatelet therapy: A case report. Exp Ther Med 29: 124, 2025.
APA
Shao, C., Zou, D., Wang, J., Lai, J., & Wu, N. (2025). Pituitary apoplexy in a patient on antiplatelet therapy: A case report. Experimental and Therapeutic Medicine, 29, 124. https://doi.org/10.3892/etm.2025.12874
MLA
Shao, C., Zou, D., Wang, J., Lai, J., Wu, N."Pituitary apoplexy in a patient on antiplatelet therapy: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 124.
Chicago
Shao, C., Zou, D., Wang, J., Lai, J., Wu, N."Pituitary apoplexy in a patient on antiplatelet therapy: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 124. https://doi.org/10.3892/etm.2025.12874
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