Open Access

Role and research progress of histone modification in cardiovascular diseases (Review)

  • Authors:
    • Qing Qi
    • Lin Li
    • Hao Liang
    • Yidi Zeng
  • View Affiliations

  • Published online on: May 13, 2025     https://doi.org/10.3892/etm.2025.12882
  • Article Number: 132
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As society evolves and lifestyles change, there has been a notable rise in the incidence of cardiovascular diseases due to a parallel rise in associated risk factors. In recent years, considerable research has been conducted on the impact of histone modifications in relation to these conditions. Processes such as acetylation, methylation and phosphorylation of histones, mediated by specific enzymes, are essential in the regulation of gene expression, which in turn influences cellular functions and the progression of diseases. Research shows that alterations in specific histone modifications are closely linked to the onset and advancement of cardiovascular conditions. For instance, significant variations in histone deacetylases and H3K27 methylation have been observed in cases of heart failure and myocardial ischemia‑reperfusion injury. In the present review, it was aimed to summarize recent findings in this area, providing a foundation for further exploration of the mechanisms by which histone modifications contribute to cardiovascular diseases.
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July-2025
Volume 30 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Qi Q, Li L, Liang H and Zeng Y: Role and research progress of histone modification in cardiovascular diseases (Review). Exp Ther Med 30: 132, 2025.
APA
Qi, Q., Li, L., Liang, H., & Zeng, Y. (2025). Role and research progress of histone modification in cardiovascular diseases (Review). Experimental and Therapeutic Medicine, 30, 132. https://doi.org/10.3892/etm.2025.12882
MLA
Qi, Q., Li, L., Liang, H., Zeng, Y."Role and research progress of histone modification in cardiovascular diseases (Review)". Experimental and Therapeutic Medicine 30.1 (2025): 132.
Chicago
Qi, Q., Li, L., Liang, H., Zeng, Y."Role and research progress of histone modification in cardiovascular diseases (Review)". Experimental and Therapeutic Medicine 30, no. 1 (2025): 132. https://doi.org/10.3892/etm.2025.12882