Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2025 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2025 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the ABCC8 c.2500C>T mutation: Potential risk factors associated with SGLT2 inhibitors

  • Authors:
    • Jing Zou
    • Xiang Chen
    • Hong-Ping Yu
    • Ying Chen
    • Kai-Ying He
    • Dan-Dan Ruan
    • Juan Zhu
    • Qian Chen
    • Jian-Hui Zhang
    • Li Zhang
    • Yu-Mian Gan
    • Mei-Zhu Gao
    • Li Chen
    • Ji-Xing Liang
    • Tian-Min Wu
    • Li-Sheng Liao
    • Jie-Wei Luo
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine and Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China, The First Clinical Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Department of Endocrinology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Traditional Chinese Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Hematology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 164
    |
    Published online on: June 26, 2025
       https://doi.org/10.3892/etm.2025.12914
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mature‑onset diabetes of the young (MODY) is an autosomal dominant genetic disease that is typically diagnosed during childhood or early adolescence. The primary pathogenesis of MODY involves gene mutations that impair insulin synthesis and/or secretion by islet β cells, rendering the condition independent of insulin resistance. A family with the MODY‑12 phenotype caused by an ATP‑binding cassette subfamily C member 8 (ABCC8) gene mutation was investigated in the present study. Clinical data were collected from all family members, and second‑generation gene sequencing and Sanger sequencing were performed. The suspected pathogenic mutation was validated by Sanger sequencing, and the three‑dimensional structure of the pathogenic variant protein was predicted and simulated using the Swiss‑Model platform. Five individuals with MODY‑12, including the proband, were identified in this family. Second‑generation gene sequencing confirmed that all family members carried the ABCC8 c.2500C>T (p.Arg834Cys) mutation. Structural modeling revealed that the replacement of arginine at position 834 in the wild‑type protein with cysteine results in the formation of an additional hydrogen bond with the surrounding amino acids. In addition, the ABCC8 c.2500C>T carriers in this family experienced recurrent diabetic ketoacidosis and acute kidney involvement (AKI) phenotypes, and all patients had a history of sodium‑glucose transporter 2 inhibitor (SGLT2i) use. We hypothesize that AKI in these patients may be pseudo‑AKI associated with the use of SGLT2is. However, the proband exhibited symptoms indicative of rapidly progressing diabetic nephropathy. This study demonstrates that clinicians managing patients with MODY should be aware of the risk of acute and serious complications, particularly as SGLT2i may induce pseudo‑AKI, which could ultimately compromise patients' long‑term renal prognosis.
View Figures

Figure 1

Pedigree and genetic analysis of a
family affected by maturity-onset diabetes of the young-12. (A)
Pedigree of the family. Squares denote males, circles denote
females and blue shading indicates heterozygous carriers of the
ABCC8 c.2500C>T (p.Arg834Cys) variant. (B) Sanger
sequencing chromatogram of the ABCC8 gene, showing the
location of the c.2500C>T (p.Arg834Cys) mutation in exon 21. (C)
Sanger sequencing chromatogram of wild-type ABCC8 exon 21,
with the c.2500C nucleotide peak indicated by an arrow. ABCC8,
ATP-binding cassette, subfamily C, member 8; C, cytosine; T,
thymine; Arg, arginine; Cys, cysteine.

Figure 2

Modeling of the wild-type and
p.Arg834Cys SUR1 proteins encoded by ABCC8. (A) Overall
homology model of the ABCC8-encoded SUR1 protein. Detailed
view of (B) the Arg834 side chain in the wild-type structure and
(C) the Cys834 side chain in the p.Arg834Cys mutant. (D)
Hydrogen-bonding interactions between Arg834 and adjacent residues
in the wild-type model. (E) Altered hydrogen-bonding network of
Cys834 with neighboring residues in the mutant model. ABCC8,
ATP-binding cassette, subfamily C, member 8; SUR1, sulfonylurea
receptor 1; Arg, arginine; Cys, cysteine.

Figure 3

Function and structural organization
of the KATP channel. (A) Role of the KATP
channel in the secretion of insulin by pancreatic β cells.
ABCC8 c.2500C>T (p.Arg834Cys) mutation impairs
KATP channel expression and activity, thereby disrupting
membrane electrophysiology and reducing insulin secretion. (B)
Schematic of the KATP channel octameric assembly,
comprising four Kir6.2 pore-forming subunits and four SUR1
regulatory subunits. KATP, ATP-sensitive potassium;
ABCC8, ATP-binding cassette, subfamily C, member 8; SUR1,
sulfonylurea receptor 1; C, cytosine; T, thymine; Arg, arginine;
Cys, cysteine.

Figure 4

Graphical abstract illustrating the
effects of the pathogenic ABCC8 variant. The ABCC8
c.2500C>T (p.Arg834Cys) pathogenic variant disrupts the tertiary
structure of the protein and compromises KATP channel
activity and glucose-stimulated insulin secretion in pancreatic β
cells, thereby culminating in the clinical manifestations of
MODY-12 and AKI. KATP, ATP-sensitive potassium; ABCC8,
ATP-binding cassette, subfamily C, member 8; C, cytosine; T,
thymine; Arg, arginine; Cys, cysteine; MODY-12, maturity-onset
diabetes of the young-12; AKI, acute kidney injury.
View References

1 

Aarthy R, Aston-Mourney K, Mikocka-Walus A, Radha V, Amutha A, Anjana RM, Unnikrishnan R and Mohan V: Clinical features, complications and treatment of rarer forms of maturity-onset diabetes of the young (MODY) - A review. J Diabetes Complications. 35(107640)2021.PubMed/NCBI View Article : Google Scholar

2 

Li J, Wang X, Mao H, Wen L, Deng A, Li Y, Zhang H and Liu C: Precision therapy for three Chinese families with maturity-onset diabetes of the young (MODY12). Front Endocrinol (Lausanne). 13(858096)2022.PubMed/NCBI View Article : Google Scholar

3 

Yahaya TO and Ufuoma SB: Genetics and pathophysiology of maturity-onset diabetes of the young (MODY): A review of current trends. Oman Med J. 35(e126)2020.PubMed/NCBI View Article : Google Scholar

4 

Fajans SS and Bell GI: MODY: History, genetics, pathophysiology, and clinical decision making. Diabetes Care. 34:1878–1884. 2011.PubMed/NCBI View Article : Google Scholar

5 

Shepherd M, Shields B, Hammersley S, Hudson M, McDonald TJ, Colclough K, Oram RA, Knight B, Hyde C, Cox J, et al: Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes. Diabetes Care. 39:1879–1888. 2016.PubMed/NCBI View Article : Google Scholar

6 

Irgens HU, Molnes J, Johansson BB, Ringdal M, Skrivarhaug T, Undlien DE, Søvik O, Joner G, Molven A and Njølstad PR: Prevalence of monogenic diabetes in the population-based norwegian childhood diabetes registry. Diabetologia. 56:1512–1519. 2013.PubMed/NCBI View Article : Google Scholar

7 

Tattersall RB and Fajans SS: A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people. Diabetes. 24:44–53. 1975.PubMed/NCBI View Article : Google Scholar

8 

Kant R, Davis A and Verma V: Maturity-onset diabetes of the young: Rapid evidence review. Am Fam Physician. 105:162–167. 2022.PubMed/NCBI

9 

Ovsyannikova AK, Rymar OD, Shakhtshneider EV, Voropaeva EN, Ivanoshchuk DE and Voevoda MI: MODY in Siberia-molecular genetics and clinical characteristics. Diabetes Mellitus. 20:5–12. 2017.(In Russ).

10 

Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, Grody WW, Hegde M, Lyon E, Spector E, et al: Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of medical genetics and genomics and the association for molecular pathology. Genet Med. 17:405–424. 2015.PubMed/NCBI View Article : Google Scholar

11 

Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC and Ferrin TE: UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem. 25:1605–1612. 2004.PubMed/NCBI View Article : Google Scholar

12 

American Diabetes Association. 6. Glycemic targets: Standards of medical care in diabetes-2019. Diabetes Care. 42 (Suppl 1):S61–S70. 2019.PubMed/NCBI View Article : Google Scholar

13 

Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, et al: Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM. Diabetes. 47:476–481. 1998.PubMed/NCBI View Article : Google Scholar

14 

Olson TM and Terzic A: Human K(ATP) channelopathies: Diseases of metabolic homeostasis. Pflugers Arch. 460:295–306. 2010.PubMed/NCBI View Article : Google Scholar

15 

Fukuda Y, Aguilar-Bryan L, Vaxillaire M, Dechaume A, Wang Y, Dean M, Moitra K, Bryan J and Schuetz JD: Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8. J Biol Chem. 286:8481–8492. 2011.PubMed/NCBI View Article : Google Scholar

16 

De Franco E, Saint-Martin C, Brusgaard K, Knight Johnson AE, Aguilar-Bryan L, Bowman P, Arnoux JB, Larsen AR, Sanyoura M, Greeley SAW, et al: Update of variants identified in the pancreatic β-cell K(ATP) channel genes KCNJ11 and ABCC8 in individuals with congenital hyperinsulinism and diabetes. Hum Mutat. 41:884–905. 2020.PubMed/NCBI View Article : Google Scholar

17 

Babenko AP, Polak M, Cave H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M and Froguel P: Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med. 355:456–466. 2006.PubMed/NCBI View Article : Google Scholar

18 

Rafiq M, Flanagan SE, Patch AM, Shields BM, Ellard S and Hattersley AT: Neonatal Diabetes International Collaborative Group. Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations. Diabetes Care. 31:204–209. 2008.PubMed/NCBI View Article : Google Scholar

19 

Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M and Rutter GA: A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Diabetes. 57:1595–1604. 2008.PubMed/NCBI View Article : Google Scholar

20 

Proks P, Girard C and Ashcroft FM: Functional effects of KCNJ11 mutations causing neonatal diabetes: Enhanced activation by MgATP. Hum Mol Genet. 14:2717–2726. 2005.PubMed/NCBI View Article : Google Scholar

21 

Yan FF, Lin YW, MacMullen C, Ganguly A, Stanley CA and Shyng SL: Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: Identification and rescue. Diabetes. 56:2339–2348. 2007.PubMed/NCBI View Article : Google Scholar

22 

de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS and Ashcroft FM: Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. Proc Natl Acad Sci USA. 104:18988–18992. 2007.PubMed/NCBI View Article : Google Scholar

23 

Ashcroft FM: ATP-sensitive potassium channelopathies: Focus on insulin secretion. J Clin Invest. 115:2047–2058. 2005.PubMed/NCBI View Article : Google Scholar

24 

Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, et al: Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 373:2117–2128. 2015.PubMed/NCBI View Article : Google Scholar

25 

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ and Buse JB: Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American diabetes association (ADA) and the European association for the study of diabetes (EASD). Diabetes Care. 41:2669–2701. 2018.PubMed/NCBI View Article : Google Scholar

26 

Kaze AD, Zhuo M, Kim SC, Patorno E and Paik JM: Association of SGLT2 inhibitors with cardiovascular, kidney, and safety outcomes among patients with diabetic kidney disease: A meta-analysis. Cardiovasc Diabetol. 21(47)2022.PubMed/NCBI View Article : Google Scholar

27 

DeFronzo RA, Norton L and Abdul-Ghani M: Renal, metabolic and cardiovascular considerations of SGLT2 inhibition. Nat Rev Nephrol. 13:11–26. 2017.PubMed/NCBI View Article : Google Scholar

28 

Hahn K, Ejaz AA, Kanbay M, Lanaspa MA and Johnson RJ: Acute kidney injury from SGLT2 inhibitors: Potential mechanisms. Nat Rev Nephrol. 12:711–712. 2016.PubMed/NCBI View Article : Google Scholar

29 

Myers SR, Glaser NS, Trainor JL, Nigrovic LE, Garro A, Tzimenatos L, Quayle KS, Kwok MY, Rewers A, Stoner MJ, et al: Frequency and risk factors of acute kidney injury during diabetic ketoacidosis in children and association with neurocognitive outcomes. JAMA Netw Open. 3(e2025481)2020.PubMed/NCBI View Article : Google Scholar

30 

Yang H, Yang L, Jardine MJ, Arnott C, Neuen BL, Xu K, Zhao X, Qian D, Cui B, Qiu Y, et al: The association between sodium-glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: A propensity-matched study. Eur J Med Res. 29(621)2024.PubMed/NCBI View Article : Google Scholar

31 

Chang YK, Choi H, Jeong JY, Na KR, Lee KW, Lim BJ and Choi DE: Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury. PLoS One. 11(e0158810)2016.PubMed/NCBI View Article : Google Scholar

32 

Heyman SN, Rosenberger C, Rosen S and Khamaisi M: Why is diabetes mellitus a risk factor for contrast-induced nephropathy? Biomed Res Int. 2013(123589)2013.PubMed/NCBI View Article : Google Scholar

33 

Errabelli P, Lathiya M and Singh D: Case report: A case of pseudo-acute kidney injury due to cyclin-dependent kinase inhibitor. Front Nephrol. 4(1389562)2024.PubMed/NCBI View Article : Google Scholar

34 

Huang SK, Huang CY, Lin CH, Cheng BW, Chiang YT, Lee YC, Yeh SN, Chan CI, Chua WK, Lee YJ and Ting WH: Acute kidney injury is a common complication in children and adolescents hospitalized for diabetic ketoacidosis. PLoS One. 15(e0239160)2020.PubMed/NCBI View Article : Google Scholar

35 

Damman K and Testani JM: The kidney in heart failure: An update. Eur Heart J. 36:1437–1444. 2015.PubMed/NCBI View Article : Google Scholar

36 

Drozdzal S, Lechowicz K, Szostak B, Rosik J, Kotfis K, Machoy-Mokrzyńska A, Białecka M, Ciechanowski K and Gawrońska-Szklarz B: Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature. Pharmacol Res Perspect. 9(e00817)2021.PubMed/NCBI View Article : Google Scholar

37 

Deng K, Pei M, Li B, Yang N, Wang Z, Wan X, Zhong Z, Yang Z and Chen Y: Signal pathways involved in contrast-induced acute kidney injury. Front Physiol 2024; 15: 1490725.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zou J, Chen X, Yu H, Chen Y, He K, Ruan D, Zhu J, Chen Q, Zhang J, Zhang L, Zhang L, et al: Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors. Exp Ther Med 30: 164, 2025.
APA
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D. ... Luo, J. (2025). Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors. Experimental and Therapeutic Medicine, 30, 164. https://doi.org/10.3892/etm.2025.12914
MLA
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D., Zhu, J., Chen, Q., Zhang, J., Zhang, L., Gan, Y., Gao, M., Chen, L., Liang, J., Wu, T., Liao, L., Luo, J."Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors". Experimental and Therapeutic Medicine 30.2 (2025): 164.
Chicago
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D., Zhu, J., Chen, Q., Zhang, J., Zhang, L., Gan, Y., Gao, M., Chen, L., Liang, J., Wu, T., Liao, L., Luo, J."Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors". Experimental and Therapeutic Medicine 30, no. 2 (2025): 164. https://doi.org/10.3892/etm.2025.12914
Copy and paste a formatted citation
x
Spandidos Publications style
Zou J, Chen X, Yu H, Chen Y, He K, Ruan D, Zhu J, Chen Q, Zhang J, Zhang L, Zhang L, et al: Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors. Exp Ther Med 30: 164, 2025.
APA
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D. ... Luo, J. (2025). Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors. Experimental and Therapeutic Medicine, 30, 164. https://doi.org/10.3892/etm.2025.12914
MLA
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D., Zhu, J., Chen, Q., Zhang, J., Zhang, L., Gan, Y., Gao, M., Chen, L., Liang, J., Wu, T., Liao, L., Luo, J."Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors". Experimental and Therapeutic Medicine 30.2 (2025): 164.
Chicago
Zou, J., Chen, X., Yu, H., Chen, Y., He, K., Ruan, D., Zhu, J., Chen, Q., Zhang, J., Zhang, L., Gan, Y., Gao, M., Chen, L., Liang, J., Wu, T., Liao, L., Luo, J."Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the <em>ABCC8</em> c.2500C&gt;T mutation: Potential risk factors associated with SGLT2 inhibitors". Experimental and Therapeutic Medicine 30, no. 2 (2025): 164. https://doi.org/10.3892/etm.2025.12914
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team