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Article

Morphological changes after corneal stromal lenticule excimer laser shaping

  • Authors:
    • Xiaoxuan Wang
    • Xiaopeng Liu
    • Jie Hou
    • Sijun Liu
    • Shirui Yang
    • Yulin Lei
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Binzhou Medical University, Binzhou, Shandong 256603, P.R. China, Department of Ophthalmology, Jinan Mingshui Eye Hospital, Jinan, Shandong 250200, P.R. China, Department of Ophthalmology, Weifang Eye Hospital, Weifang, Shandong 261072, P.R. China
  • Article Number: 186
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    Published online on: August 5, 2025
       https://doi.org/10.3892/etm.2025.12936
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Abstract

The present study aimed to investigate the feasibility and design of producing a parallel/concave lenticule using an excimer laser on a convex corneal matrix lenticule in vitro. Optical coherence tomography was used to measure the thickness of the corneal stromal lenticules. Lenticules were cut using an excimer laser. The lenticules were divided into three groups: 1:1, 1:1.5 and 1:2 cuttings. After cutting, the lenticule thickness was measured again. Thickness changes in the three groups were compared before and after the cuts. Significant differences were observed among the three groups in central thickness, thickness changes (1.5 mm) and the difference between central thickness and thickness (2 mm from the centre) before and after cutting. However, thickness changes at 2 and 2.5 mm from the centre were not statistically significant. The differences between the central thickness and thickness at 2 mm from the centre after shaping (with interquartile ranges) were as follows: 38 (28, 53.5) µm in Group Ⅰ, 6 (‑3,15.5) µm in Group II and ‑10 (‑16.5, ‑5) µm in Group III. In conclusion, excimer cutting at different proportions affected thickness changes at the centre and 1.5 mm from the centre. Furthermore, it did not affect the thickness change at 2 and 2.5 mm from the centre. The lenticule obtained by a 1:1 cutting ratio was convex and the lenticule formed by a 1:1.5 cutting ratio retained a convex shape. However, the centre was very close to the parallel lenticule. The lenticule obtained using a 1:2 cutting ratio was concave.
View Figures

Figure 1

Comparison before and after shaping.
Optical coherence tomography scans before shaping (top) and after
shaping (bottom). (A) The 1:1 excimer cutting based on the
equivalent spherical lenticule of the lenticule itself. The
comparison images before and after the cutting process are
presented. (B) The 1:1.5 excimer cutting based on the equivalent
spherical lenticule of the lenticule itself. the comparison images
before and after the cutting process are presented. (C) The 1:2
excimer cutting based on the equivalent spherical lenticule of the
lenticule itself. the comparison images before and after the
cutting process are presented.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Liu X, Hou J, Liu S, Yang S and Lei Y: Morphological changes after corneal stromal lenticule excimer laser shaping. Exp Ther Med 30: 186, 2025.
APA
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., & Lei, Y. (2025). Morphological changes after corneal stromal lenticule excimer laser shaping. Experimental and Therapeutic Medicine, 30, 186. https://doi.org/10.3892/etm.2025.12936
MLA
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., Lei, Y."Morphological changes after corneal stromal lenticule excimer laser shaping". Experimental and Therapeutic Medicine 30.4 (2025): 186.
Chicago
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., Lei, Y."Morphological changes after corneal stromal lenticule excimer laser shaping". Experimental and Therapeutic Medicine 30, no. 4 (2025): 186. https://doi.org/10.3892/etm.2025.12936
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Liu X, Hou J, Liu S, Yang S and Lei Y: Morphological changes after corneal stromal lenticule excimer laser shaping. Exp Ther Med 30: 186, 2025.
APA
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., & Lei, Y. (2025). Morphological changes after corneal stromal lenticule excimer laser shaping. Experimental and Therapeutic Medicine, 30, 186. https://doi.org/10.3892/etm.2025.12936
MLA
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., Lei, Y."Morphological changes after corneal stromal lenticule excimer laser shaping". Experimental and Therapeutic Medicine 30.4 (2025): 186.
Chicago
Wang, X., Liu, X., Hou, J., Liu, S., Yang, S., Lei, Y."Morphological changes after corneal stromal lenticule excimer laser shaping". Experimental and Therapeutic Medicine 30, no. 4 (2025): 186. https://doi.org/10.3892/etm.2025.12936
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