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Correlation of telomere length between full and preterm neonates and their mothers

  • Authors:
    • Elena Vakonaki
    • Maria Theodora Vitiadou
    • Nefeli Ioanna Paraskevopoulou
    • Manolis Tzatzarakis
    • Stella Baliou
    • Petros Ioannou
    • Athanasios Alegakis
    • Thomas Lamprakis
    • Persefoni Fragkiadaki
    • Eleftheria Mylonaki
    • Zoi Volonaki
    • Nicolina Anagnostatou
    • Fanourios Makrygiannakis
    • Antonios Makrigiannakis
    • Demetrios A. Spandidos
    • Aristides Tsatsakis
    • Eleftheria Hatzidaki
  • View Affiliations / Copyright

    Affiliations: Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Internal Medicine and Infectious Diseases, University Hospital of Heraklion, 71110 Heraklion, Greece, Department of Neonatology and Neonatal Intensive Care Unit, University Hospital of Heraklion, 71500 Heraklion, Greece, Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71500 Heraklion, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Vakonaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 187
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    Published online on: August 5, 2025
       https://doi.org/10.3892/etm.2025.12937
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Abstract

Telomeres are nucleoprotein complexes that serve as protective caps from the DNA damage response at the ends of chromosomes. During aging, telomeres gradually shorten, and genomic instability arises through the induction of senescence. The present study aimed to elucidate the association between maternal characteristics, their medical history and pregnancy details with the telomere length (TL) of neonates. Blood samples were collected from 54 mothers and their neonates, and DNA extraction and measurement of TL was performed by quantitavive PCR. The results showed that maternal TL was negatively correlated with body mass index before pregnancy. A weak to moderate significant correlation was observed between maternal and neonatal TL. Non‑significant differences were found between the maternal TL and their smoking habits, as well as medical and gestation history.
View Figures

Figure 1

Association of maternal vs. neonatal
telomere length (kilobases). TL, telomere length.

Figure 2

Maternal and neonatal characteristics
in single pregnancies: Correlations with telomere length.
View References

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Spandidos Publications style
Vakonaki E, Vitiadou MT, Paraskevopoulou NI, Tzatzarakis M, Baliou S, Ioannou P, Alegakis A, Lamprakis T, Fragkiadaki P, Mylonaki E, Mylonaki E, et al: Correlation of telomere length between full and preterm neonates and their mothers. Exp Ther Med 30: 187, 2025.
APA
Vakonaki, E., Vitiadou, M.T., Paraskevopoulou, N.I., Tzatzarakis, M., Baliou, S., Ioannou, P. ... Hatzidaki, E. (2025). Correlation of telomere length between full and preterm neonates and their mothers. Experimental and Therapeutic Medicine, 30, 187. https://doi.org/10.3892/etm.2025.12937
MLA
Vakonaki, E., Vitiadou, M. T., Paraskevopoulou, N. I., Tzatzarakis, M., Baliou, S., Ioannou, P., Alegakis, A., Lamprakis, T., Fragkiadaki, P., Mylonaki, E., Volonaki, Z., Anagnostatou, N., Makrygiannakis, F., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A., Hatzidaki, E."Correlation of telomere length between full and preterm neonates and their mothers". Experimental and Therapeutic Medicine 30.4 (2025): 187.
Chicago
Vakonaki, E., Vitiadou, M. T., Paraskevopoulou, N. I., Tzatzarakis, M., Baliou, S., Ioannou, P., Alegakis, A., Lamprakis, T., Fragkiadaki, P., Mylonaki, E., Volonaki, Z., Anagnostatou, N., Makrygiannakis, F., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A., Hatzidaki, E."Correlation of telomere length between full and preterm neonates and their mothers". Experimental and Therapeutic Medicine 30, no. 4 (2025): 187. https://doi.org/10.3892/etm.2025.12937
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Spandidos Publications style
Vakonaki E, Vitiadou MT, Paraskevopoulou NI, Tzatzarakis M, Baliou S, Ioannou P, Alegakis A, Lamprakis T, Fragkiadaki P, Mylonaki E, Mylonaki E, et al: Correlation of telomere length between full and preterm neonates and their mothers. Exp Ther Med 30: 187, 2025.
APA
Vakonaki, E., Vitiadou, M.T., Paraskevopoulou, N.I., Tzatzarakis, M., Baliou, S., Ioannou, P. ... Hatzidaki, E. (2025). Correlation of telomere length between full and preterm neonates and their mothers. Experimental and Therapeutic Medicine, 30, 187. https://doi.org/10.3892/etm.2025.12937
MLA
Vakonaki, E., Vitiadou, M. T., Paraskevopoulou, N. I., Tzatzarakis, M., Baliou, S., Ioannou, P., Alegakis, A., Lamprakis, T., Fragkiadaki, P., Mylonaki, E., Volonaki, Z., Anagnostatou, N., Makrygiannakis, F., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A., Hatzidaki, E."Correlation of telomere length between full and preterm neonates and their mothers". Experimental and Therapeutic Medicine 30.4 (2025): 187.
Chicago
Vakonaki, E., Vitiadou, M. T., Paraskevopoulou, N. I., Tzatzarakis, M., Baliou, S., Ioannou, P., Alegakis, A., Lamprakis, T., Fragkiadaki, P., Mylonaki, E., Volonaki, Z., Anagnostatou, N., Makrygiannakis, F., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A., Hatzidaki, E."Correlation of telomere length between full and preterm neonates and their mothers". Experimental and Therapeutic Medicine 30, no. 4 (2025): 187. https://doi.org/10.3892/etm.2025.12937
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