Primary soft tissue chondroma of the anterior mediastinum: A case report and comprehensive literature review

Zhang,Yaping; Geng,Xiaotao; Zhang,Min; Li,Changshuai; Pang,Mingyuan

doi:10.3892/etm.2025.12966

November-2025 Volume 30 Issue 5

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November-2025 Volume 30 Issue 5

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Case Report Open Access

Primary soft tissue chondroma of the anterior mediastinum: A case report and comprehensive literature review

Authors:
- Yaping Zhang
- Xiaotao Geng
- Min Zhang
- Changshuai Li
- Mingyuan Pang
View Affiliations / Copyright

Affiliations: Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Radiation Oncology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 216
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Published online on: September 9, 2025

https://doi.org/10.3892/etm.2025.12966
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Abstract

Anterior mediastinal soft tissue chondroma is an exceedingly rare benign tumor that poses a diagnostic challenge due to its overlapping imaging features with more common mediastinal masses. Accurate diagnosis is crucial to ensure appropriate surgical management and avoid overtreatment of benign lesions. In the present case, a 36‑year‑old asymptomatic woman presented with a calcified anterior mediastinal mass incidentally detected on a routine chest computed tomography. Imaging showed a well‑circumscribed, lobulated mass with punctate calcifications, suggestive of a benign etiology. The mass was resected and histopathological evaluation confirmed a diagnosis of soft tissue chondroma. Complete surgical resection was performed via median sternotomy without complications. The patient had an uneventful recovery and remained disease‑free at the 6‑month follow‑up. This case emphasizes the need to consider anterior mediastinal soft tissue chondromas in the differential diagnosis of calcified mediastinal masses.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary soft tissue chondroma of the anterior mediastinum: A case report and comprehensive literature review

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