Primary epithelioid angiomatous nodule of the vocal cord: A case report and literature review

Li,Keda; Huang,Bin; Cai,Lubing; Huang,Mingqi; Shi,Jianping; Jin,Mingdi; Qian,Ning; Guo,Yongkang

doi:10.3892/etm.2025.13008

January-2026 Volume 31 Issue 1

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January-2026 Volume 31 Issue 1

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Case Report Open Access

Primary epithelioid angiomatous nodule of the vocal cord: A case report and literature review

Authors:
- Keda Li
- Bin Huang
- Lubing Cai
- Mingqi Huang
- Jianping Shi
- Mingdi Jin
- Ning Qian
- Yongkang Guo
View Affiliations / Copyright

Affiliations: Department of Ear, Nose and Throat, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China, Department of Traditional Chinese Medicine, Faculty of Chinese Medical Science, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region 530222, P.R. China, Department of Anorectal Surgery, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, Τhe Traditional Chinese Medicine Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China

Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 13
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Published online on: October 29, 2025

https://doi.org/10.3892/etm.2025.13008
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Abstract

A primary epithelioid angiomatous nodule (EAN) of the vocal cord is a rare vascular endothelial cell‑derived lesion. The present study describes the clinical, histopathological and immunohistochemical characteristics of a 31‑year‑old male patient with EAN of the vocal cord and reviews the relevant literature. The patient complained of recurrent hoarseness for over a month. A fiber laryngoscopy revealed a red polypoid mass on the left vocal cord. Post‑surgical resection, the microscopic examination revealed clear tumor boundaries, a solid arrangement of epithelioid tumor cells, obvious nucleoli, vacuolated nuclei, eosinophilic or clear cytoplasm, no mitotic figures and scant inflammatory cell infiltration. The immunohistochemical results also showed positivity for CD34 and CD31 in the tumor cells. Fluorescence in situ hybridization excluded calmodulin‑binding transcription activator 1 rearrangement. The patient was followed up for 6 months and no recurrence was found. However, close follow‑up is necessary in this case due to a positive surgical margin.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary epithelioid angiomatous nodule of the vocal cord: A case report and literature review

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