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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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March-2026 Volume 31 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Use of metagenomic next‑generation sequencing to diagnose Tropheryma whipplei infection‑related pneumonia: A case report

  • Authors:
    • Yutu Luo
    • Haibing Ding
    • Jiahua Pan
    • Guangyang Xu

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Taizhou Second People's Hospital, Taizhou, Jiangsu 225500, P.R. China, Department of Cardiothoracic Surgery, Taizhou Second People's Hospital, Taizhou, Jiangsu 225500, P.R. China
  • Article Number: 75
    |
    Published online on: January 21, 2026
       https://doi.org/10.3892/etm.2026.13070
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Abstract

Whipple's disease is caused by Tropheryma whipplei (T. whipplei), an uncommon pathogen that is often related to gastrointestinal symptoms. Extraintestinal involvement, particularly pulmonary manifestations, is rare and poses notable diagnostic challenges. An objective technique for identifying undiscovered infections is the application of metagenomic next‑generation sequencing (mNGS). The present case report described a 55‑year‑old female presenting with community‑acquired pneumonia (CAP), who received empirical treatment with moxifloxacin, ultimately diagnosed through mNGS performed on bronchoalveolar lavage fluid. The results indicated that the patient was infected with T. whipplei and that the patient exhibited notable clinical improvement within 2 weeks following intravenous moxifloxacin during hospitalization and continuation of oral moxifloxacin following discharge.The present case report highlighted the utility of mNGS in diagnosing atypical infections and identified T. whipplei as a potential etiological agent of CAP in immunocompetent hosts.

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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Ding H, Pan J and Xu G: <p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>. Exp Ther Med 31: 75, 2026.
APA
Luo, Y., Ding, H., Pan, J., & Xu, G. (2026). <p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>. Experimental and Therapeutic Medicine, 31, 75. https://doi.org/10.3892/etm.2026.13070
MLA
Luo, Y., Ding, H., Pan, J., Xu, G."<p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>". Experimental and Therapeutic Medicine 31.3 (2026): 75.
Chicago
Luo, Y., Ding, H., Pan, J., Xu, G."<p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>". Experimental and Therapeutic Medicine 31, no. 3 (2026): 75. https://doi.org/10.3892/etm.2026.13070
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Ding H, Pan J and Xu G: <p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>. Exp Ther Med 31: 75, 2026.
APA
Luo, Y., Ding, H., Pan, J., & Xu, G. (2026). <p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>. Experimental and Therapeutic Medicine, 31, 75. https://doi.org/10.3892/etm.2026.13070
MLA
Luo, Y., Ding, H., Pan, J., Xu, G."<p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>". Experimental and Therapeutic Medicine 31.3 (2026): 75.
Chicago
Luo, Y., Ding, H., Pan, J., Xu, G."<p>Use of metagenomic next‑generation sequencing to diagnose <em>Tropheryma whipplei</em> infection‑related pneumonia: A case report</p>". Experimental and Therapeutic Medicine 31, no. 3 (2026): 75. https://doi.org/10.3892/etm.2026.13070
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