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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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April-2026 Volume 31 Issue 4

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Case Report

A novel human papillomavirus‑induced ‘doughnut wart’ lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report

  • Authors:
    • Ke Li
    • Yitao Qian
    • Wenjing Zha
    • Lei Shi

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Huadong Hospital, Fudan University, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Shanghai 200040, P.R. China, Department of Dermatology, Huadong Hospital, Fudan University, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Shanghai 200040, P.R. China
  • Article Number: 93
    |
    Published online on: February 4, 2026
       https://doi.org/10.3892/etm.2026.13088
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Abstract

The present study reports ‘doughnut wart’, a novel human papillomavirus (HPV)‑associated viral wart characterized by central regression and peripheral ring‑shaped proliferation after cryotherapy or other treatments, likely due to treatment‑altered microenvironments promoting viral spread. A 21‑year‑old female with a post‑cryotherapy plantar doughnut wart was treated with CO2 laser debridement followed by three weekly 5‑aminolevulinic acid photodynamic therapy (ALA‑PDT) sessions. Complete healing was achieved with no recurrence at 1 year. During the sixth follow‑up visit in June 2025, samples were collected from the patient for HPV detection, which confirmed the absence of recurrence. ALA‑PDT eliminates HPV‑infected cells through reactive oxygen species, activates local immunity (including immunogenic cell death) and preserves skin barriers, offering a precise, recurrence‑reducing approach superior to conventional therapies, which can disrupt barriers and promote viral spread.

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Copy and paste a formatted citation
Spandidos Publications style
Li K, Qian Y, Zha W and Shi L: <p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>. Exp Ther Med 31: 93, 2026.
APA
Li, K., Qian, Y., Zha, W., & Shi, L. (2026). <p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>. Experimental and Therapeutic Medicine, 31, 93. https://doi.org/10.3892/etm.2026.13088
MLA
Li, K., Qian, Y., Zha, W., Shi, L."<p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>". Experimental and Therapeutic Medicine 31.4 (2026): 93.
Chicago
Li, K., Qian, Y., Zha, W., Shi, L."<p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>". Experimental and Therapeutic Medicine 31, no. 4 (2026): 93. https://doi.org/10.3892/etm.2026.13088
Copy and paste a formatted citation
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Spandidos Publications style
Li K, Qian Y, Zha W and Shi L: <p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>. Exp Ther Med 31: 93, 2026.
APA
Li, K., Qian, Y., Zha, W., & Shi, L. (2026). <p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>. Experimental and Therapeutic Medicine, 31, 93. https://doi.org/10.3892/etm.2026.13088
MLA
Li, K., Qian, Y., Zha, W., Shi, L."<p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>". Experimental and Therapeutic Medicine 31.4 (2026): 93.
Chicago
Li, K., Qian, Y., Zha, W., Shi, L."<p>A novel human papillomavirus‑induced &lsquo;doughnut wart&rsquo; lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report</p>". Experimental and Therapeutic Medicine 31, no. 4 (2026): 93. https://doi.org/10.3892/etm.2026.13088
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