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Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)

  • Authors:
    • Weicheng Lin
    • Lan Luo
    • Guiping Guo
    • Huan Lin
  • View Affiliations / Copyright

    Affiliations: The First School of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, Department of Breast Surgery, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 155
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    Published online on: April 8, 2026
       https://doi.org/10.3892/etm.2026.13150
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Abstract

Breast‑conserving surgery (BCS) with radiotherapy is a standard treatment for early‑stage breast cancer, offering survival outcomes equivalent to mastectomy while preserving breast appearance and improving quality of life. However, BCS suitability and effectiveness vary notably among patients due to differences in age, comorbidities, tumor biology, breast anatomy and psychosocial factors. Through a systematic review, the present study identified six patient subgroups that may derive limited benefit from BCS followed by radiotherapy. These constituted the elderly with multiple comorbidities, those with ductal carcinoma in situ, premenopausal women with aggressive tumor subtypes, patients with cardiac contraindications to radiotherapy, individuals at high risk of poor cosmetic outcomes and those with socioeconomic constraints. For these patients, alternative procedures such as mastectomy with immediate reconstruction may provide improved oncologic or functional results. The present analysis highlights the importance of a personalized, risk‑adapted approach to surgical decision‑making in breast cancer. By integrating clinical, pathological and sociodemographic variables, the present study supports treatment strategies that are not only valid within oncology but also aligned with the functional needs and psychological well‑being of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lin W, Luo L, Guo G and Lin H: Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review). Exp Ther Med 31: 155, 2026.
APA
Lin, W., Luo, L., Guo, G., & Lin, H. (2026). Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review). Experimental and Therapeutic Medicine, 31, 155. https://doi.org/10.3892/etm.2026.13150
MLA
Lin, W., Luo, L., Guo, G., Lin, H."Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)". Experimental and Therapeutic Medicine 31.6 (2026): 155.
Chicago
Lin, W., Luo, L., Guo, G., Lin, H."Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)". Experimental and Therapeutic Medicine 31, no. 6 (2026): 155. https://doi.org/10.3892/etm.2026.13150
Copy and paste a formatted citation
x
Spandidos Publications style
Lin W, Luo L, Guo G and Lin H: Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review). Exp Ther Med 31: 155, 2026.
APA
Lin, W., Luo, L., Guo, G., & Lin, H. (2026). Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review). Experimental and Therapeutic Medicine, 31, 155. https://doi.org/10.3892/etm.2026.13150
MLA
Lin, W., Luo, L., Guo, G., Lin, H."Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)". Experimental and Therapeutic Medicine 31.6 (2026): 155.
Chicago
Lin, W., Luo, L., Guo, G., Lin, H."Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)". Experimental and Therapeutic Medicine 31, no. 6 (2026): 155. https://doi.org/10.3892/etm.2026.13150
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