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Case Report Open Access

Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report

  • Authors:
    • Xue Zhang
    • Ruizeng Feng
    • Congwen Chen
    • Wei Liu
    • Yabing Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First People's Hospital of Xiantao, Affiliated Hospital of Hubei University of Science and Technology, Xiantao, Hubei 433000, P.R. China, Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Gastrointestinal Surgery, The First People's Hospital of Xiantao, Affiliated Hospital of Hubei University of Science and Technology, Xiantao, Hubei 433000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 167
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    Published online on: April 14, 2026
       https://doi.org/10.3892/etm.2026.13162
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Abstract

Aggressive fibromatosis (AF) is a rare borderline tumor characterized by locally infiltrative growth and a high risk of recurrence, but no metastatic potential. Intra‑abdominal AF may present with nonspecific symptoms and is often misdiagnosed due to its overlapping imaging features with more common mesenchymal tumors. Within the present study, a case of incomplete small bowel obstruction caused by abdominal AF in a 45‑year‑old male is presented. In August 2025, the patient initially presented to Qianjiang Central Hospital (Qianjiang, China) with abdominal pain and obstructive symptoms. Abdominal CT scan identified a large soft‑tissue mass leading to small intestinal obstruction. In October 2025, the patient underwent surgical resection. Histopathological analysis determined the diagnosis of AF, with immunohistochemical staining demonstrating nuclear positivity for β‑catenin. Postoperative recovery was uneventful. The present case demonstrated that AF, although uncommon, should be included in the differential diagnosis of abdominal masses associated with bowel obstruction. Definitive diagnosis depends on histopathology and comprehensive immunohistochemical evaluation. For symptomatic cases, complete surgical excision is the mainstay of treatment and long‑term follow‑up is warranted due to the potential for local recurrence.
View Figures

Figure 1

Initial abdominal CT findings.
Abdominal CT scan showing (A) soft tissue mass in the lower abdomen
accompanied by (B) small intestinal obstruction (obtained in August
2025).

Figure 2

CT scan showing a neoplastic lesion
measuring 49x56x63 mm in the lower abdomen (the midline area of the
pelvic cavity, along with incomplete small bowel obstruction)
(obtained in October 2025).

Figure 3

Gross appearance. Protuberant mass
observed on the serosal side of the intestinal wall (obtained in
November 2025).

Figure 4

Pathology of aggressive fibromatosis.
(A) Fibroblasts and myofibroblasts were arranged in bundles
(magnification, x100; scale bar, 73 µm). (B) Scattered collagen
fiber components in tumor tissue; and (C) tumor tissue invaded the
surrounding adipose tissue (H&E staining; magnification, x40;
scale bar, 221 µm). (D) Immunohistochemistry showed that the
specific marker β-catenin was expressed in cell nuclei in tumor
tissue (magnification, x100; scale bar, 73 µm) (all of the
above-mentioned images were obtained in November 2025).

Figure 5

Immunohistochemical indicators based
on the requirements of differential diagnosis: (A) Signal
transducer and activator of transcription 6 (-); (B) c-KIT (CD117)
(-); (C) discovered on GIST-1 (-); (D) anaplastic lymphoma kinase
(D5F3) (-); (E) S100 (-); (F) SRY-box transcription factor 10 (-);
(G) smooth muscle actin (-); (H) Desmin (-); (I) CD34 (-); (J)
succinate dehydrogenase complex subunit B (+); and (K) fumarate
hydratase (+). (L) Ki67 protein was expressed at low levels in
tumor tissue (magnification, x40; scale bar, 221 µm) (all of the
above-mentioned images were obtained in November 2025).

Figure 6

Postoperative follow-up ultrasound
images. (A) Abdominal and (B) retroperitoneal ultrasound. No
masses, lymphadenopathy, bowel dilatation or abnormal fluid
collection were observed. Color Doppler showed no abnormal flow
signals (obtained in February 2026).
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Spandidos Publications style
Zhang X, Feng R, Chen C, Liu W and Wei Y: Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report. Exp Ther Med 31: 167, 2026.
APA
Zhang, X., Feng, R., Chen, C., Liu, W., & Wei, Y. (2026). Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report. Experimental and Therapeutic Medicine, 31, 167. https://doi.org/10.3892/etm.2026.13162
MLA
Zhang, X., Feng, R., Chen, C., Liu, W., Wei, Y."Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report". Experimental and Therapeutic Medicine 31.6 (2026): 167.
Chicago
Zhang, X., Feng, R., Chen, C., Liu, W., Wei, Y."Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report". Experimental and Therapeutic Medicine 31, no. 6 (2026): 167. https://doi.org/10.3892/etm.2026.13162
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Spandidos Publications style
Zhang X, Feng R, Chen C, Liu W and Wei Y: Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report. Exp Ther Med 31: 167, 2026.
APA
Zhang, X., Feng, R., Chen, C., Liu, W., & Wei, Y. (2026). Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report. Experimental and Therapeutic Medicine, 31, 167. https://doi.org/10.3892/etm.2026.13162
MLA
Zhang, X., Feng, R., Chen, C., Liu, W., Wei, Y."Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report". Experimental and Therapeutic Medicine 31.6 (2026): 167.
Chicago
Zhang, X., Feng, R., Chen, C., Liu, W., Wei, Y."Aggressive fibromatosis resulting in incomplete intestinal obstruction: A case report". Experimental and Therapeutic Medicine 31, no. 6 (2026): 167. https://doi.org/10.3892/etm.2026.13162
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