Postmenopausal complete hydatidiform mole: A case report

Uysal,Emre

doi:10.3892/etm.2026.13165

June-2026 Volume 31 Issue 6

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June-2026 Volume 31 Issue 6

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Article Open Access

Postmenopausal complete hydatidiform mole: A case report

Authors:
- Emre Uysal
View Affiliations / Copyright

Affiliations: Department of Gynecology and Obstetrics, Eregli State Hospital, Eregli, Konya 42310, Turkiye

Copyright: © Uysal et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 170
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Published online on: April 20, 2026

https://doi.org/10.3892/etm.2026.13165
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Abstract

Complete hydatidiform mole (CHM) cases occurring in the postmenopausal period are quite rare and may be delayed in diagnosis. In the present study, the case reported is of a 55‑year‑old postmenopausal woman (menopausal for 5 years) who presented with painless postmenopausal bleeding in March 2025, ongoing for ~1 month and was diagnosed with CHM. Transvaginal ultrasonography showed endometrial thickness of 28‑mm and serum β‑human chorionic gonadotropin (β‑hCG) level of 187,240 mIU/ml. After ultrasound‑guided curettage, the diagnosis of CHM was confirmed in histopathological examination. Since the patient was postmenopausal, laparoscopic hysterectomy and bilateral salpingo‑oophorectomy were performed. Postoperative follow‑up was performed in accordance with International Federation of Gynecology and Obstetrics (FIGO) guidelines; the protocol used (weekly β‑hCG until negative, then monthly for 6 months) is fully consistent with the 2025 FIGO update. By December 2025, the patient had successfully finished the suggested follow‑up regimen and was still in total remission with no signs of recurrence. In patients with abnormal uterine bleeding and high β‑hCG levels in the postmenopausal period, gestational trophoblastic diseases should be considered in the differential diagnosis. Malignant complications can be prevented with early diagnosis and treatment.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Postmenopausal complete hydatidiform mole: A case report

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