|
1
|
Bray F, Laversanne M, Sung H, Ferlay J,
Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics
2022: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 18 countries. CA Cancer J Clin. 74:229–263.
2024.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Siegel RL, Kratzer TB, Giaquinto AN, Sung
H and Jemal A: Cancer statistics, 2025. CA Cancer J Clin. 75:10–45.
2025.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Trevino V, Oyervides M, Ramírez-Correa GA
and Garza L: Generating human papillomavirus (HPV) reference
databases to maximize genomic mapping. Arch Virol. 167:57–65.
2022.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Burd EM: Human papillomavirus and cervical
cancer. Clin Microbiol Rev. 16:1–17. 2003.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Harper DM, Franco EL, Wheeler C, Ferris
DG, Jenkins D, Schuind A, Zahaf T, Innis B, Naud P, De Carvalho NS,
et al: Efficacy of a bivalent L1 virus-like particle vaccine in
prevention of infection with human papillomavirus types 16 and 18
in young women: A randomised controlled trial. Lancet.
364:1757–1765. 2004.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Zhang X, Zeng Q, Cai W and Ruan W: Trends
of cervical cancer at global, regional, and national level: Data
from the global burden of disease study 2019. BMC Public Health.
21(894)2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Arbyn M, Weiderpass E, Bruni L, de Sanjosé
S, Saraiya M, Ferlay J and Bray F: Estimates of incidence and
mortality of cervical cancer in 2018: A worldwide analysis. Lancet
Glob Health. 8:e191–e203. 2020.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Human papillomavirus vaccines: WHO
position paper, December 2022. Wkly Epidemiol Rec. 50:645–672.
2022.
|
|
9
|
FUTURE II Study Group. Quadrivalent
vaccine against human papillomavirus to prevent high-grade cervical
lesions. N Engl J Med. 356:1915–1927. 2007.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Brisson M, Kim JJ, Canfell K, Drolet M,
Gingras G, Burger EA, Martin D, Simms KT, Bénard É, Boily MC, et
al: Impact of HPV vaccination and cervical screening on cervical
cancer elimination: A comparative modelling analysis in 78
low-income and lower-middle-income countries. Lancet. 395:575–590.
2020.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Hussain S, Nasare V, Kumari M, Sharma S,
Khan MA, Das BC and Bharadwaj M: Perception of human papillomavirus
infection, cervical cancer and HPV vaccination in North Indian
population. PLoS One. 9(e112861)2014.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Graham SV: Human papillomavirus: Gene
expression, regulation and prospects for novel diagnostic methods
and antiviral therapies. Future Microbiol. 5:1493–1506.
2010.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Doorbar J: The E4 protein; structure,
function and patterns of expression. Virology. 445:80–98.
2013.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Yao Y, Yan Z, Dai S, Li C, Yang L, Liu S,
Zhang X, Shi L and Yao Y: Human papillomavirus type 16 E1 mutations
associated with cervical cancer in a Han Chinese population. Int J
Med Sci. 16:1042–1049. 2019.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Ren S, Gaykalova DA, Guo T, Favorov AV,
Fertig EJ, Tamayo P, Callejas-Valera JL, Allevato M, Gilardi M,
Santos J, et al: HPV E2, E4, E5 drive alternative carcinogenic
pathways in HPV positive cancers. Oncogene. 39:6327–6339.
2020.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Giorgi Rossi P, Carozzi F, Ronco G, Allia
E, Bisanzi S, Gillio-Tos A, De Marco L, Rizzolo R, Gustinucci D,
Del Mistro A, et al: p16/ki67 and E6/E7 mRNA accuracy and
prognostic value in triaging HPV DNA-positive women. J Natl Cancer
Inst. 113:292–300. 2021.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Conrad M, Bubb VJ and Schlegel R: The
human papillomavirus type 6 and 16 E5 proteins are
membrane-associated proteins which associate with the 16 kilodalton
pore-forming protein. J Virol. 67:6170–6178. 1993.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Eriksson A, Herron JR, Yamada T and
Wheeler CM: Human papillomavirus type 16 variant lineages
characterized by nucleotide sequence analysis of the E5 coding
segment and the E2 hinge region. J Gen Virol. 80:595–600.
1999.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Disbrow GL, Hanover JA and Schlegel R:
Endoplasmic reticulum-localized human papillomavirus type 16 E5
protein alters endosomal pH but not trans-Golgi pH. J Virol.
79:5839–5846. 2005.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Straight SW, Herman B and McCance DJ: The
E5 oncoprotein of human papillomavirus type 16 inhibits the
acidification of endosomes in human keratinocytes. J Virol.
69:3185–3192. 1995.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Venuti A, Paolini F, Nasir L, Corteggio A,
Roperto S, Campo MS and Borzacchiello G: The smallest oncoprotein
with many functions. Mol Cancer. 10(140)2011.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Scott ML, Coleman DT, Kelly KC, Carroll
JL, Woodby B, Songock WK, Cardelli JA and Bodily JM: Human
papillomavirus type 16 E5-mediated upregulation of Met in human
keratinocytes. Virology. 519:1–11. 2018.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Campo MS, Graham SV, Cortese MS, Ashrafi
GH, Araibi EH, Dornan ES, Miners K, Nunes C and Man S: HPV-16 E5
down-regulates expression of surface HLA class I and reduces
recognition by CD8 T cells. Virology. 407:137–142. 2010.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Miyauchi S, Sanders PD, Guram K, Kim SS,
Paolini F, Venuti A, Cohen EEW, Gutkind JS, Califano JA and Sharabi
AB: HPV16 E5 mediates resistance to PD-L1 blockade and can be
targeted with rimantadine in head and neck cancer. Cancer Res.
80:732–746. 2020.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Barrett T, Wilhite SE, Ledoux P,
Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH,
Sherman PM, Holko M, et al: NCBI GEO: Archive for functional
genomics data sets-update. Nucleic Acids Res. 41:D991–D995.
2013.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Ahn EY, DeKelver RC, Lo MC, Nguyen TA,
Matsuura S, Boyapati A, Pandit S, Fu XD and Zhang DE: SON controls
cell-cycle progression by coordinated regulation of RNA splicing.
Mol Cell. 42:185–198. 2011.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Noordhuis MG, Fehrmann RS, Wisman GB,
Nijhuis ER, van Zanden JJ, Moerland PD, Ver Loren van Themaat E,
Volders HH, Kok M, ten Hoor KA, et al: Involvement of the TGF-beta
and beta-catenin pathways in pelvic lymph node metastasis in
early-stage cervical cancer. Clin Cancer Res. 17:1317–1330.
2011.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Scotto L, Narayan G, Nandula SV,
Arias-Pulido H, Subramaniyam S, Schneider A, Kaufmann AM, Wright
JD, Pothuri B, Mansukhani M and Murty VV: Identification of copy
number gain and overexpressed genes on chromosome arm 20q by an
integrative genomic approach in cervical cancer: Potential role in
progression. Genes Chromosomes Cancer. 47:755–765. 2008.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Bachtiary B, Boutros PC, Pintilie M, Shi
W, Bastianutto C, Li JH, Schwock J, Zhang W, Penn LZ, Jurisica I,
et al: Gene expression profiling in cervical cancer: An exploration
of intratumor heterogeneity. Clin Cancer Res. 12:5632–5640.
2006.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Zhai Y, Kuick R, Nan B, Ota I, Weiss SJ,
Trimble CL, Fearon ER and Cho KR: Gene expression analysis of
preinvasive and invasive cervical squamous cell carcinomas
identifies HOXC10 as a key mediator of invasion. Cancer Res.
67:10163–10172. 2007.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Huang da W, Sherman BT and Lempicki RA:
Systematic and integrative analysis of large gene lists using DAVID
bioinformatics resources. Nat Protoc. 4:44–57. 2009.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Thomas PD, Ebert D, Muruganujan A,
Mushayahama T, Albou LP and Mi H: Making genome-scale phylogenetics
accessible to all. Protein Sci. 31:8–22. 2022.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Ashburner M, Ball CA, Blake JA, Botstein
D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT,
et al: Gene ontology: Tool for the unification of biology. The Gene
Ontology Consortium. Nat Genet. 25:25–29. 2000.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Kanehisa M and Sato Y: KEGG Mapper for
inferring cellular functions from protein sequences. Protein Sci.
29:28–35. 2020.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Szklarczyk D, Gable AL, Nastou KC, Lyon D,
Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, et al:
The STRING database in 2021: Customizable protein-protein networks,
and functional characterization of user-uploaded gene/measurement
sets. Nucleic Acids Res. 49:D605–D612. 2021.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and
Lin CY: CytoHubba: Identifying hub objects and sub-networks from
complex interactome. BMC Syst Biol. 8 (Suppl)(S11)2014.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G,
Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al:
Integrative analysis of complex cancer genomics and clinical
profiles using the cBioPortal. Sci Signal. 6(l1)2013.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Stelzer G, Rosen N, Plaschkes I, Zimmerman
S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, et
al: The gene cards suite: From gene data mining to disease genome
sequence analyses. Curr Protoc Bioinformatics. 54:1.30.1–1.30.33.
2016.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Tang Z, Li C, Kang B, Gao G, Li C and
Zhang Z: GEPIA: A web server for cancer and normal gene expression
profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102.
2017.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Uhlén M, Fagerberg L, Hallström BM,
Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C,
Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the
human proteome. Science. 347(1260419)2015.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Warde-Farley D, Donaldson SL, Comes O,
Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT,
et al: The GeneMANIA prediction server: Biological network
integration for gene prioritization and predicting gene function.
Nucleic Acids Res. 38:W214–W220. 2010.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Zhou G, Soufan O, Ewald J, Hancock REW,
Basu N and Xia J: NetworkAnalyst 3.0: A visual analytics platform
for comprehensive gene expression profiling and meta-analysis.
Nucleic Acids Res. 47:W234–W241. 2019.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Montenont E, Rondina MT and Campbell RA:
Campbell, Altered functions of platelets during aging. Curr Opin
Hematol. 26:336–342. 2019.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Chen HL, Wang QY, Qi RM and Cai JP:
Identification of the changes in the platelet proteomic profile of
elderly individuals. Front Cardiovasc Med.
11(1384679)2024.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Syrjanen KJ: HPV infections and
oesophageal cancer. J Clin Pathol. 55:721–728. 2002.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Thomas M, Pim D and Banks L: The role of
the E6-p53 interaction in the molecular pathogenesis of HPV.
Oncogene. 18:7690–7700. 1999.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Maufort JP, Shai A, Pitot HC and Lambert
PF: A role for HPV16 E5 in cervical carcinogenesis. Cancer Res.
70:2924–2931. 2010.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Chang JL, Tsao YP, Liu DW, Huang SJ, Lee
WH and Chen SL: The expression of HPV-16 E5 protein in squamous
neoplastic changes in the uterine cervix. J Biomed Sci. 8:206–213.
2001.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Kim SW and Yang JS: Human papillomavirus
type 16 E5 protein as a therapeutic target. Yonsei Med J. 47:1–14.
2006.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Crusius K, Rodriguez I and Alonso A: The
human papillomavirus type 16 E5 protein modulates ERK1/2 and p38
MAP kinase activation by an EGFR-independent process in stressed
human keratinocytes. Virus Genes. 20:65–69. 2000.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Crusius K, Auvinen E and Alonso A:
Enhancement of EGF- and PMA-mediated MAP kinase activation in cells
expressing the human papillomavirus type 16 E5 protein. Oncogene.
15:1437–1444. 1997.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Chen SL, Lin YK, Li LY, Tsao YP, Lo HY,
Wang WB and Tsai TC: E5 proteins of human papillomavirus types 11
and 16 transactivate the c-fos promoter through the NF1 binding
element. J Virol. 70:8558–8563. 1996.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Chen SL, Huang CH, Tsai TC, Lu KY and Tsao
YP: The regulation mechanism of c-jun and junB by human
papillomavirus type 16 E5 oncoprotein. Arch Virol. 141:791–800.
1996.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Ye Q, Putila J, Raese R, Dong C, Qian Y,
Dowlati A and Guo NL: Identification of prognostic and
chemopredictive microRNAs for non-small-cell lung cancer by
integrating SEER-medicare data. Int J Mol Sci.
22(7658)2021.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Wu Z, Xia F and Lin R: LncRNA HOTAIR
influences the growth, migration, and invasion of papillary thyroid
carcinoma via affection on the miR-488-5p/NUP205 axis. Technol
Cancer Res Treat. 19(1533033820962125)2020.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Ji L, Fu J, Hao J, Ji Y, Wang H, Wang Z,
Wang P and Xiao H: Proteomics analysis of tissue small
extracellular vesicles reveals protein panels for the reoccurrence
prediction of colorectal cancer. J Proteomics.
249(104347)2021.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Mackay DR, Howa AC, Werner TL and Ullman
KS: Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair
foci by antagonizing BRCA1-dependent events. J Cell Sci.
130:3347–3359. 2017.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Wei Z, Xu J, Li W, Ou L, Zhou Y, Wang Y
and Shi B: SMARCC1 enters the nucleus via KPNA2 and plays an
oncogenic role in bladder cancer. Front Mol Biosci.
9(902220)2022.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Kindermann B, Valkova C, Krämer A, Perner
B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH,
Oswald F, et al: The nuclear pore proteins Nup88/214 and T-cell
acute lymphatic leukemia-associated NUP214 fusion proteins regulate
Notch signaling. J Biol Chem. 294:11741–11750. 2019.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Brustmann H and Hager M: Nucleoporin 88
expression in normal and neoplastic squamous epithelia of the
uterine cervix. Ann Diagn Pathol. 13:303–307. 2009.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Schneider J, Martínez-Arribas F and
Torrejón R: Nup88 expression is associated with myometrial invasion
in endometrial carcinoma. Int J Gynecol Cancer. 20:804–808.
2010.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Taniuchi K, Yawata T, Tsuboi M, Ueba T and
Saibara T: Efficient delivery of small interfering RNAs targeting
particular mRNAs into pancreatic cancer cells inhibits invasiveness
and metastasis of pancreatic tumors. Oncotarget. 10:2869–2886.
2019.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Ciriello G, Cerami E, Sander C and Schultz
N: Mutual exclusivity analysis identifies oncogenic network
modules. Genome Res. 22:398–406. 2012.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Smitherman M, Lee K, Swanger J, Kapur R
and Clurman BE: Characterization and targeted disruption of murine
Nup50, a p27(Kip1)-interacting component of the nuclear pore
complex. Mol Cell Biol. 20:5631–4562. 2000.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Kalverda B, Pickersgill H, Shloma VV and
Fornerod M: Nucleoporins directly stimulate expression of
developmental and cell-cycle genes inside the nucleoplasm. Cell.
140:360–371. 2010.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Badial K, Lacayo P and Murakami S: Biology
of healthy aging: Biological hallmarks of stress resistance related
and unrelated to longevity in humans. Int J Mol Sci.
25(10493)2024.PubMed/NCBI View Article : Google Scholar
|
