HMGB1: A new marker for estimation of the postmortem interval

  • Authors:
    • Kiyoshi Kikuchi
    • Ko-Ichi Kawahara
    • Kamal K. Biswas
    • Takashi Ito
    • Salunya Tancharoen
    • Naoto Shiomi
    • Yoshiro Koda
    • Fumiyo Matsuda
    • Yoko Morimoto
    • Yoko Oyama
    • Kazunori Takenouchi
    • Naoki Miura
    • Noboru Arimura
    • Yuko Nawa
    • Shinichiro Arimura
    • Meng X. Jie
    • Binita Shrestha
    • Masahiro Iwata
    • Kentaro Mera
    • Hisayo Sameshima
    • Yoshiko Ohno
    • Ryuichi Maenosono
    • Yutaka Tajima
    • Hisaaki Uchikado
    • Terukazu Kuramoto
    • Kenji Nakayama
    • Minoru Shigemori
    • Yoshihiro Yoshida
    • Teruto Hashiguchi
    • Ikuro Maruyama
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/etm_00000019
  • Pages: 109-111
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Abstract

Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis. Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4, 14 and 24°C since death were measured by enzyme-linked immunosorbent assay. The serum HMGB1 level showed a time-dependent increase up to seven days at 4°C. At 14°C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued. At 24°C, the HMGB1 level peaked at day 2, decreased at day 3, and then plateaued. Our findings suggest that HMGB1 is related to the PMI in rats.
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January-February 2010
Volume 1 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Shiomi N, Koda Y, Matsuda F, Morimoto Y, Oyama Y, Oyama Y, et al: HMGB1: A new marker for estimation of the postmortem interval . Exp Ther Med 1: 109-111, 2010
APA
Kikuchi, K., Kawahara, K., Biswas, K.K., Ito, T., Tancharoen, S., Shiomi, N. ... Maruyama, I. (2010). HMGB1: A new marker for estimation of the postmortem interval . Experimental and Therapeutic Medicine, 1, 109-111. https://doi.org/10.3892/etm_00000019
MLA
Kikuchi, K., Kawahara, K., Biswas, K. K., Ito, T., Tancharoen, S., Shiomi, N., Koda, Y., Matsuda, F., Morimoto, Y., Oyama, Y., Takenouchi, K., Miura, N., Arimura, N., Nawa, Y., Arimura, S., Jie, M. X., Shrestha, B., Iwata, M., Mera, K., Sameshima, H., Ohno, Y., Maenosono, R., Tajima, Y., Uchikado, H., Kuramoto, T., Nakayama, K., Shigemori, M., Yoshida, Y., Hashiguchi, T., Maruyama, I."HMGB1: A new marker for estimation of the postmortem interval ". Experimental and Therapeutic Medicine 1.1 (2010): 109-111.
Chicago
Kikuchi, K., Kawahara, K., Biswas, K. K., Ito, T., Tancharoen, S., Shiomi, N., Koda, Y., Matsuda, F., Morimoto, Y., Oyama, Y., Takenouchi, K., Miura, N., Arimura, N., Nawa, Y., Arimura, S., Jie, M. X., Shrestha, B., Iwata, M., Mera, K., Sameshima, H., Ohno, Y., Maenosono, R., Tajima, Y., Uchikado, H., Kuramoto, T., Nakayama, K., Shigemori, M., Yoshida, Y., Hashiguchi, T., Maruyama, I."HMGB1: A new marker for estimation of the postmortem interval ". Experimental and Therapeutic Medicine 1, no. 1 (2010): 109-111. https://doi.org/10.3892/etm_00000019