HMGB1: A new marker for estimation of the postmortem interval

Kikuchi,Kiyoshi; Kawahara,Ko-Ichi; Biswas,Kamal K.; Ito,Takashi; Tancharoen,Salunya; Shiomi,Naoto; Koda,Yoshiro; Matsuda,Fumiyo; Morimoto,Yoko; Oyama,Yoko; Takenouchi,Kazunori; Miura,Naoki; Arimura,Noboru; Nawa,Yuko; Arimura,Shinichiro; Jie,Meng X.; Shrestha,Binita; Iwata,Masahiro; Mera,Kentaro; Sameshima,Hisayo; Ohno,Yoshiko; Maenosono,Ryuichi; Tajima,Yutaka; Uchikado,Hisaaki; Kuramoto,Terukazu; Nakayama,Kenji; Shigemori,Minoru; Yoshida,Yoshihiro; Hashiguchi,Teruto; Maruyama,Ikuro

doi:10.3892/etm_00000019

January-February 2010 Volume 1 Issue 1

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January-February 2010 Volume 1 Issue 1

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Article

HMGB1: A new marker for estimation of the postmortem interval

Authors:
- Kiyoshi Kikuchi
- Ko-Ichi Kawahara
- Kamal K. Biswas
- Takashi Ito
- Salunya Tancharoen
- Naoto Shiomi
- Yoshiro Koda
- Fumiyo Matsuda
- Yoko Morimoto
- Yoko Oyama
- Kazunori Takenouchi
- Naoki Miura
- Noboru Arimura
- Yuko Nawa
- Shinichiro Arimura
- Meng X. Jie
- Binita Shrestha
- Masahiro Iwata
- Kentaro Mera
- Hisayo Sameshima
- Yoshiko Ohno
- Ryuichi Maenosono
- Yutaka Tajima
- Hisaaki Uchikado
- Terukazu Kuramoto
- Kenji Nakayama
- Minoru Shigemori
- Yoshihiro Yoshida
- Teruto Hashiguchi
- Ikuro Maruyama
View Affiliations / Copyright

Affiliations: Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan
Pages: 109-111
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Published online on: January 1, 2010

https://doi.org/10.3892/etm_00000019
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Abstract

Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine. Numerous methods have been proposed for the determination of the time since death by chemical means. High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis. Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4, 14 and 24°C since death were measured by enzyme-linked immunosorbent assay. The serum HMGB1 level showed a time-dependent increase up to seven days at 4°C. At 14°C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued. At 24°C, the HMGB1 level peaked at day 2, decreased at day 3, and then plateaued. Our findings suggest that HMGB1 is related to the PMI in rats.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

HMGB1: A new marker for estimation of the postmortem interval

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Abstract

Figure 1

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