Selenium-Bifidobacterium longum as a delivery system of endostatin for inhibition of pathogenic bacteria and selective regression of solid tumor

Li,Chen; Chen,Xu; Kou,Lei; Hu,Bi; Zhu,Li-Ping; Fan,Yan-Rong; Wu,Zhi-Wei; Wang,Jian-Jun; Xu,Gen-Xing

doi:10.3892/etm_00000022

January-February 2010 Volume 1 Issue 1

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January-February 2010 Volume 1 Issue 1

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Article

Selenium-Bifidobacterium longum as a delivery system of endostatin for inhibition of pathogenic bacteria and selective regression of solid tumor

Authors:
- Chen Li
- Xu Chen
- Lei Kou
- Bi Hu
- Li-Ping Zhu
- Yan-Rong Fan
- Zhi-Wei Wu
- Jian-Jun Wang
- Gen-Xing Xu
View Affiliations / Copyright

Affiliations: Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, P.R. China
Pages: 129-135
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Published online on: January 1, 2010

https://doi.org/10.3892/etm_00000022
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Abstract

Bifidobacterium longum (B. longum) as a delivery system for endostatin was shown to have definite antitumor effects. Moreover, it was found that the enrichment of selenium was able to enhance the immunity of mice. In order to further evaluate the safety and efficacy of B. longum carrying pBV22210-endostatin (B. longum-En) enriched with selenium (Se-B. longum-En), we determined the biochemical characteristics of Se-B. longum-En. We then investigated its effect on macrophage activity, as well as its inhibitory effect on the multiplication of pathogenic bacteria in vitro and the antitumor effects on murine hepatic (H22) tumor-bearing mice. The results showed that Se-B. longum-En exhibited similar biochemical characteristics to that of wild-type B. longum, i.e., Se-B. longum-En strongly enhanced macrophage phagocytosis in rats and inhibited the growth of pathogenic bacteria. In addition, Se-B. longum-En showed a definite inhibitory effect of tumor growth when H22 tumor-bearing mice were fed through oral or tail vein delivery. These results suggested that Se-B. longum is able to retain the advantages of wild-type B. longum and be used as a novel gene delivery system for liver cancer gene therapy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Selenium-Bifidobacterium longum as a delivery system of endostatin for inhibition of pathogenic bacteria and selective regression of solid tumor

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Abstract

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