Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-February 2010 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2010 Volume 1 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Genome-wide comparison of FGFRL1 with structurally related surface receptors

  • Authors:
    • Lei Zhuang
    • Laurent Falquet
    • Beat Trueb
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland
  • Pages: 161-168
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/etm_00000026
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

FGFRL1 (FGFR5) is a member of the fibroblast growth factor receptor family, which lacks the intracellular tyrosine kinase domain required for signal transduction by trans-phosphorylation. Since it still contains a cytoplasmic domain of 100 amino acid residues with a peculiar histidine-rich element, it might be involved in an alternative pathway of downstream signaling. To get a clue about a possible mechanism, we compared the overall structure of FGFRL1 with all proteins from the UniProt databank. We found that the human genome encodes 42 structurally related proteins with a signal peptide, three Ig-like domains and a transmembrane domain. These proteins can be grouped in seven families, fibroblast growth factor receptors (FGFRs), Fc receptor-like proteins, IL-1 receptor-like proteins, killer cell Ig-like receptors (KIRs), nectin-like proteins, sialic acid binding lectins (SIGLECs) and signal regulatory proteins (SIRPs). The 7 families utilize four different strategies for signaling, namely a protein tyrosine kinase domain, a TIR (Toll/IL-1 receptor) domain, ITIM/ITAM motifs as well as carboxy-terminal peptides that interact with the PDZ domain of an adaptor protein. It remains to be determined whether FGFRL1 might also utilize one of these strategies for signaling.
View Figures

Figure 1

View References

1. 

Itoh N: The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease. Biol Pharm Bull. 30:1819–1825. 2007. View Article : Google Scholar : PubMed/NCBI

2. 

Itoh N and Ornitz DM: Evolution of the Fgf and Fgfr gene families. Trends Genet. 20:563–569. 2004. View Article : Google Scholar : PubMed/NCBI

3. 

Eswarakumar VP, Lax I and Schlessinger J: Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16:139–149. 2005. View Article : Google Scholar : PubMed/NCBI

4. 

Wilkie AO: Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. Cytokine Growth Factor Rev. 16:187–203. 2005. View Article : Google Scholar : PubMed/NCBI

5. 

Coumoul X and Deng CX: Roles of FGF receptors in mammalian development and congenital diseases. Birth Defects Res C Embryo Today. 69:286–304. 2003. View Article : Google Scholar : PubMed/NCBI

6. 

Wiedemann M and Trueb B: Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 69:275–279. 2000. View Article : Google Scholar : PubMed/NCBI

7. 

Sleeman M, Fraser J, McDonald M, Yuan S, White D, Grandison P, Kumble K, Watson JD and Murison JG: Identification of a new fibroblast growth factor receptor, FGFR5. Gene. 271:171–182. 2001. View Article : Google Scholar : PubMed/NCBI

8. 

Kim I, Moon S-O, Yu K-H, Kim U-H and Koh GY: A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. Biochim Biophys Acta. 1518:152–156. 2001. View Article : Google Scholar : PubMed/NCBI

9. 

Trueb B, Zhuang L, Taeschler S and Wiedemann M: Characterization of FGFRL1, a novel FGF receptor preferentially expressed in cartilage. J Biol Chem. 278:33857–33865. 2003. View Article : Google Scholar : PubMed/NCBI

10. 

Trueb B and Taeschler S: Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development. Int J Mol Med. 17:617–620. 2006.PubMed/NCBI

11. 

Rieckmann T, Kotevic I and Trueb B: The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp Cell Res. 314:1071–1081. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Rieckmann T, Zhuang L, Flück CE and Trueb B: Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient. Biochim Biophys Acta. 1792:112–121. 2009. View Article : Google Scholar : PubMed/NCBI

13. 

Baertschi S, Zhuang L and Trueb B: Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm. FEBS J. 274:6241–6253. 2007. View Article : Google Scholar : PubMed/NCBI

14. 

Hall C, Flores MV, Murison G, Crosier K and Crosier P: An essential role for zebrafish Fgfrl1 during gill cartilage development. Mech Dev. 123:925–940. 2006. View Article : Google Scholar : PubMed/NCBI

15. 

Catela C, Bilbao-Cortes D, Slonimsky E, Kratsios P, Rosenthal N and Te Welscher P: Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice. Dis Model Mech. 2:283–294. 2009. View Article : Google Scholar : PubMed/NCBI

16. 

Barclay AN: Ig-like domains: evolution from simple interaction molecules to sophisticated antigen recognition. Proc Natl Acad Sci USA. 96:14672–14674. 1999. View Article : Google Scholar : PubMed/NCBI

17. 

Smith DK and Xue H: Sequence profiles of immunoglobulin and immunoglobulin-like domains. J Mol Biol. 12:530–545. 1997. View Article : Google Scholar : PubMed/NCBI

18. 

Hau J, Muller M and Pagni M: HitKeeper, a generic software package for hit list management. Source Code Biol Med. 28:2:22007.PubMed/NCBI

19. 

Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D and Falquet L: MyHits: improvements to an interactive resource for analyzing protein sequences. Nucleic Acids Res. 35:W433–W437. 2007.PubMed/NCBI

20. 

UniProt Consortium: The universal protein resource (UniProt). Nucleic Acids Res. 36:D190–D195. 2008.

21. 

Finn RD, Tate J, Mistry J, Coggill PC, Sammut JS, Hotz HR, Ceric G, Forslund K, Eddy SR, Sonnhammer EL and Bateman A: The Pfam protein families database. Nucleic Acids Res. 36:D281–D288. 2008. View Article : Google Scholar : PubMed/NCBI

22. 

Letunic I, Copley RR, Pils B, Pinkert S, Schultz J and Bork P: SMART 5: domains in the context of genomes and networks. Nucleic Acids Res. 34:D257–D260. 2006. View Article : Google Scholar : PubMed/NCBI

23. 

Hulo N, Bairoch A, Bulliard V, Cerutti L, De Castro E, Langendijk-Genevaux PS, Pagni M and Sigrist CJA: The PROSITE database. Nucleic Acids Res. 34:D227–D230. 2006. View Article : Google Scholar

24. 

Käll L, Krogh A and Sonnhammer EL: A combined transmembrane topology and signal peptide prediction method. J Mol Biol. 338:1027–1036. 2004.PubMed/NCBI

25. 

Davis RS: Fc receptor-like molecules. Annu Rev Immunol. 25:525–560. 2007. View Article : Google Scholar : PubMed/NCBI

26. 

O’Neill LA: The interleukin-1 receptor/Toll-like receptor super-family: 10 years of progress. Immunol Rev. 226:10–18. 2008.PubMed/NCBI

27. 

Boraschi D and Tagliabue A: The interleukin-1 receptor family. Vitam Horm. 74:229–254. 2006. View Article : Google Scholar

28. 

Gardiner CM: Killer cell immunoglobulin-like receptors on NK cells: the how, where and why. Int J Immunogenet. 35:1–8. 2008. View Article : Google Scholar : PubMed/NCBI

29. 

Long EO: Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev. 224:70–84. 2008. View Article : Google Scholar : PubMed/NCBI

30. 

Miyoshi J and Takai Y: Nectin and nectin-like molecules: biology and pathology. Am J Nephrol. 27:590–604. 2007. View Article : Google Scholar : PubMed/NCBI

31. 

Rikitake Y and Takai Y: Interactions of the cell adhesion molecule nectin with transmembrane and peripheral membrane proteins for pleiotropic functions. Cell Mol Life Sci. 65:253–263. 2008. View Article : Google Scholar : PubMed/NCBI

32. 

Crocker PR and Redelinghuys P: Siglecs as positive and negative regulators of the immune system. Biochem Soc Trans. 36:1467–1471. 2008. View Article : Google Scholar : PubMed/NCBI

33. 

Von Gunten S and Bochner BS: Basic and clinical immunology of Siglecs. Ann N Y Acad Sci. 1143:61–82. 2008.

34. 

Barclay AN and Brown MH: The SIRP family of receptors and immune regulation. Nat Rev Immunol. 6:457–464. 2006. View Article : Google Scholar : PubMed/NCBI

35. 

Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, Elliston K, Stern D and Shaw A: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem. 267:14998–15004. 1992.PubMed/NCBI

36. 

Yurchenko V, Constant S and Bukrinsky M: Dealing with the family: CD147 interactions with cyclophilins. Immunology. 117:301–309. 2006. View Article : Google Scholar : PubMed/NCBI

37. 

Fuchs A, Cella M, Giurisato E, Shaw AS and Colonna M: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol. 172:3994–3998. 2004. View Article : Google Scholar : PubMed/NCBI

38. 

Mager DL, Hunter DG, Schertzer M and Freeman JD: Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3). Genomics. 59:255–263. 1999. View Article : Google Scholar : PubMed/NCBI

39. 

Barrow AD and Trowsdale J: You say ITAM and I say ITIM, let’s call the whole thing off: the ambiguity of immunoreceptor signalling. Eur J Immunol. 36:1646–1653. 2006.PubMed/NCBI

40. 

Daeron M, Jaeger S, Du Pasquier L and Vivier E: Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev. 224:11–43. 2008. View Article : Google Scholar : PubMed/NCBI

41. 

Pinheiro da Silva F, Aloulou M, Benhamou M and Monteiro RC: Inhibitory ITAMs: a matter of life and death. Trends Immunol. 29:366–373. 2008.PubMed/NCBI

42. 

Bezprozvanny I and Maximov A: Classification of PDZ domains. FEBS Lett. 509:457–462. 2001. View Article : Google Scholar : PubMed/NCBI

43. 

Maximov A, Sudhof TC and Bezprozvanny I: Association of neuronal calcium channels with modular adaptor proteins. J Biol Chem. 274:24453–24456. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhuang L, Falquet L and Trueb B: Genome-wide comparison of FGFRL1 with structurally related surface receptors . Exp Ther Med 1: 161-168, 2010.
APA
Zhuang, L., Falquet, L., & Trueb, B. (2010). Genome-wide comparison of FGFRL1 with structurally related surface receptors . Experimental and Therapeutic Medicine, 1, 161-168. https://doi.org/10.3892/etm_00000026
MLA
Zhuang, L., Falquet, L., Trueb, B."Genome-wide comparison of FGFRL1 with structurally related surface receptors ". Experimental and Therapeutic Medicine 1.1 (2010): 161-168.
Chicago
Zhuang, L., Falquet, L., Trueb, B."Genome-wide comparison of FGFRL1 with structurally related surface receptors ". Experimental and Therapeutic Medicine 1, no. 1 (2010): 161-168. https://doi.org/10.3892/etm_00000026
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang L, Falquet L and Trueb B: Genome-wide comparison of FGFRL1 with structurally related surface receptors . Exp Ther Med 1: 161-168, 2010.
APA
Zhuang, L., Falquet, L., & Trueb, B. (2010). Genome-wide comparison of FGFRL1 with structurally related surface receptors . Experimental and Therapeutic Medicine, 1, 161-168. https://doi.org/10.3892/etm_00000026
MLA
Zhuang, L., Falquet, L., Trueb, B."Genome-wide comparison of FGFRL1 with structurally related surface receptors ". Experimental and Therapeutic Medicine 1.1 (2010): 161-168.
Chicago
Zhuang, L., Falquet, L., Trueb, B."Genome-wide comparison of FGFRL1 with structurally related surface receptors ". Experimental and Therapeutic Medicine 1, no. 1 (2010): 161-168. https://doi.org/10.3892/etm_00000026
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team