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Article Open Access

Statins combined with niacin reduce the risk of peripheral neuropathy

  • Authors:
    • Steven Lehrer
    • Peter H. Rheinstein
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Severn Health Solutions, Severna Park, MD 21146, USA
    Copyright: © Lehrer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 3
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    Published online on: June 9, 2020
       https://doi.org/10.3892/ijfn.2020.3
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Abstract

Statins are a class of lipid-lowering medications that reduce illness and mortality in those who are at a high risk of developing cardiovascular disease. They are the most common cholesterol-lowering drugs. A case control study published in 2002 indicated that statins may increase the risk of peripheral neuropathy. Statin users were 14-fold more likely to develop peripheral neuropathy than non-users, although the overall risk of developing neuropathy was minimal. However, a number of other studies have produced conflicting results regarding neuropathy and statins. Statins are frequently combined with niacin (vitamin B3). Due to its beneficial effects on lipid profiles, niacin has been prescribed for the prevention of heart disease for >40 years. Among the B vitamins, niacin has long been recognized as a key mediator of neuronal development and survival, and may be of value for the treatment of neuropathy. The present study aimed to assess whether the combination of niacin and statin may reduce the risk of peripheral neuropathy attributed to statins. For this purpose, data from MedWatch, the Food and Drug Administration (FDA) Safety Information and Adverse Event Reporting Program were analyzed. The online tool OpenVigil 2.1 was used to query the databases. The results revealed that the majority of statins alone were related to neuropathy. Pitavastatin was the only exception. The association with neuropathy was most pronounced in the lipophilic statins: Atorvastatin and fluvastatin. The association was weaker for other lipophilic statins, such as lovastatin and simvastatin. Two hydrophilic statins, rosuvastatin and pravastatin, exhibited a similarly weaker association with neuropathy, while no reports of any association of pitavastatin with neuropathy were found. Statins + niacin were unrelated to neuropathy. On the whole, the findings of the present study demonstrate that the controversial association of statins with neuropathy may be due to the fact that previous studies have not included the use of niacin and the potential neuroprotective effects of niacin. Multiple reports have stated that niacin is no longer beneficial for the management of hyperlipidemia and should be abandoned. However, given the apparent ability of niacin to reduce the risk of neuropathy, perhaps niacin should not be discarded before further studies are performed to provide more in depth information.
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1 

Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J and Sindrup SH: Statins and risk of polyneuropathy: A case-control study. Neurology. 58:1333–1337. 2002.PubMed/NCBI View Article : Google Scholar

2 

Emad M, Arjmand H, Farpour HR and Kardeh B: Lipid-lowering drugs (statins) and peripheral neuropathy. Electron Physician. 10:6527–6533. 2018.PubMed/NCBI View Article : Google Scholar

3 

Warendorf JK, Vrancken A, van Eijk RPA, Visser NA, van den Berg LH and Notermans NC: Statins do not increase risk of polyneuropathy: A case-control study and literature review. Neurology. 92:e2136–e2144. 2019.PubMed/NCBI View Article : Google Scholar

4 

Superko HR, Zhao XQ, Hodis HN and Guyton JR: Niacin and heart disease prevention: Engraving its tombstone is a mistake. J Clin Lipidol. 11:1309–1317. 2017.PubMed/NCBI View Article : Google Scholar

5 

Calderon-Ospina CA and Nava-Mesa MO: B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 26:5–13. 2020.PubMed/NCBI View Article : Google Scholar

6 

Gasperi V, Sibilano M, Savini I and Catani MV: Niacin in the central nervous system: An update of biological aspects and clinical applications. Int J Mol Sci. 20(974)2019.PubMed/NCBI View Article : Google Scholar

7 

Bolino A, Piguet F, Alberizzi V, Pellegatta M, Rivellini C, Guerrero-Valero M, Noseda R, Brombin C, Nonis A, D'Adamo P, et al: Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination. EMBO Mol Med. 8:1438–1454. 2016.PubMed/NCBI View Article : Google Scholar

8 

Kessler DA: Introducing MEDWatch. A new approach to reporting medication and device adverse effects and product problems. JAMA. 269:2765–2768. 1993.PubMed/NCBI View Article : Google Scholar

9 

Lehrer S and Rheinstein PH: Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce suicidal ideation and depression. Discov Med. 28:205–212. 2019.PubMed/NCBI

10 

Craigle V: MedWatch: The FDA safety information and adverse event reporting program. J Med Library Association. 95(224)2007.

11 

Bohm R, Hocker J, Cascorbi I and Herdegen T: OpenVigil-free eyeballs on AERS pharmacovigilance data. Nat Biotechnol. 30:137–138. 2012.PubMed/NCBI View Article : Google Scholar

12 

Böhm R, von Hehn L, Herdegen T, Klein HJ, Bruhn O, Petri H and Höcker J: OpenVigil FDA-Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications. PLoS. One. 11(e0157753)2016.PubMed/NCBI View Article : Google Scholar

13 

Coloma PM, Becker B, Sturkenboom MC, van Mulligen EM and Kors JA: Evaluating social media networks in medicines safety surveillance: Two case studies. Drug Saf. 38:921–930. 2015.PubMed/NCBI View Article : Google Scholar

14 

Evans SJ, Waller PC and Davis S: Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports. Pharmacoepidemiol Drug Saf. 10:483–486. 2001.PubMed/NCBI View Article : Google Scholar

15 

Hauben M, Reich L, DeMicco J and Kim K: ‘Extreme duplication’ in the US FDA Adverse Events Reporting System database. Drug Saf. 30:551–554. 2007.PubMed/NCBI View Article : Google Scholar

16 

Mukhtar RY, Reid J and Reckless JP: Pitavastatin. Int J Clin Pract. 59:239–252. 2005.PubMed/NCBI View Article : Google Scholar

17 

Alavijeh MS, Chishty M, Qaiser MZ and Palmer AM: Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx. 2:554–571. 2005.PubMed/NCBI View Article : Google Scholar

18 

Rosch PJ: Peripheral neuropathy. Lancet. 364:1663–1665. 2004.PubMed/NCBI View Article : Google Scholar

19 

Donaghy M: Assessing the risk of drug-induced neurologic disorders: Statins and neuropathy. Neurology. 58:1321–1322. 2002.PubMed/NCBI View Article : Google Scholar

20 

Koslik HJ, Meskimen AH and Golomb BA: Physicians' Experiences as patients with statin side effects: A case series. Drug Saf Case Rep. 4(3)2017.PubMed/NCBI View Article : Google Scholar

21 

Weimer LH and Sachdev N: Update on medication-induced peripheral neuropathy. Curr Neurol Neurosci Rep. 9:69–75. 2009.PubMed/NCBI View Article : Google Scholar

22 

Malfitano AM, Marasco G, Proto MC, Laezza C, Gazzerro P and Bifulco M: Statins in neurological disorders: An overview and update. Pharmacol Res. 88:74–83. 2014.PubMed/NCBI View Article : Google Scholar

23 

Lloyd-Jones DM: Niacin and HDL cholesterol-time to face facts. N Engl J Med. 371:271–273. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lehrer S and H. Rheinstein P: Statins combined with niacin reduce the risk of peripheral neuropathy. Int J Funct Nutr 1: 3, 2020.
APA
Lehrer, S., & H. Rheinstein, P. (2020). Statins combined with niacin reduce the risk of peripheral neuropathy. International Journal of Functional Nutrition, 1, 3. https://doi.org/10.3892/ijfn.2020.3
MLA
Lehrer, S., H. Rheinstein, P."Statins combined with niacin reduce the risk of peripheral neuropathy". International Journal of Functional Nutrition 1.1 (2020): 3.
Chicago
Lehrer, S., H. Rheinstein, P."Statins combined with niacin reduce the risk of peripheral neuropathy". International Journal of Functional Nutrition 1, no. 1 (2020): 3. https://doi.org/10.3892/ijfn.2020.3
Copy and paste a formatted citation
x
Spandidos Publications style
Lehrer S and H. Rheinstein P: Statins combined with niacin reduce the risk of peripheral neuropathy. Int J Funct Nutr 1: 3, 2020.
APA
Lehrer, S., & H. Rheinstein, P. (2020). Statins combined with niacin reduce the risk of peripheral neuropathy. International Journal of Functional Nutrition, 1, 3. https://doi.org/10.3892/ijfn.2020.3
MLA
Lehrer, S., H. Rheinstein, P."Statins combined with niacin reduce the risk of peripheral neuropathy". International Journal of Functional Nutrition 1.1 (2020): 3.
Chicago
Lehrer, S., H. Rheinstein, P."Statins combined with niacin reduce the risk of peripheral neuropathy". International Journal of Functional Nutrition 1, no. 1 (2020): 3. https://doi.org/10.3892/ijfn.2020.3
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