Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Functional Nutrition
Join Editorial Board Propose a Special Issue
Print ISSN: 2634-7989 Online ISSN: 2634-7237
Journal Cover
May-August 2021 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-August 2021 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Polyphenolic‑rich fraction of Pithecellobium dulce attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines

  • Authors:
    • Suresh Sulekha Dhanisha
    • Sudarsanan Drishya
    • Rary P. Mony
    • Chandrasekharan Guruvayoorappan
  • View Affiliations / Copyright

    Affiliations: Laboratory of Immunopharmacology and Experimental Therapeutics, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala 695011, India, Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala 695011, India
    Copyright: © Dhanisha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 7
    |
    Published online on: June 9, 2021
       https://doi.org/10.3892/ijfn.2021.17
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The fruits of Pithecellobium dulce (P. dulce) are edible, and have been consumed in Asian countries. They are considered a dense source of proteins, fats, carbohydrates and vitamins. The present study aimed to explore the antioxidant (in vitro and in vivo) effects of the fruit extract of P. dulce (FPD) against methotrexate (MTX)‑induced hepatic and renal toxicities in a BALB/c mouse model. A preliminary qualitative analysis of FPD was carried out following standard procedures. The in vitro antioxidant efficacy of FPD was evaluated by different free radical scavenging assays. In order to further validate the protective effects of FPD, an expansive in vivo experimental strategy was developed. Oxidative stress was induced in mice by an intraperitoneal (i.p) injection of MTX (20 mg/kg body weight). The protective effects of FPD against MTX‑induced oxidative stress were evaluated following the oral administration of FPD at 40 mg/kg body weight for 10 consecutive days. Preliminary qualitative analysis of FPD revealed the presence of several active phyto‑components. The in vitro antioxidant efficacy of FPD was evaluated, and a concentration‑dependent increment in antioxidant activity was observed. These data from the cell free system represent a clear approximation of the antioxidant status of potential bioactive constituents. The administration of FPD significantly reduced MTX‑induced serum hepatic and renal toxicity marker enzymes. The co‑administration of FPD also reduced the levels of tissue oxidative stress markers and enhanced the antioxidant status in the liver, kidneys and lungs of mice compared with the MTX alone group. FPD also reversed MTX‑induced pancytopenia. Furthermore, the protective effects of FPD were confirmed by tissue histopathological analysis. Additionally, treatment with FPD markedly reduced the MTX‑induced increase in the levels of serum pro‑inflammatory cytokines, such as TNF‑α, IL‑1β and IL‑6. On the whole, the findings of the present study strongly ascertain the antioxidant efficacy of FPD and its role in mitigating MTX‑induced tissue injury.
View Figures
View References

1 

Pincus T, Yazici Y, Sokka T, Aletaha D and Smolen JS: Methotrexate as the anchor drug for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol. 21 (5 Suppl 31):S179–S185. 2003.PubMed/NCBI

2 

Foell D, Frosch M, Schulze zur Wiesch A, Vogl T, Sorg C and Roth J: Methotrexate treatment in juvenile idiopathic arthritis: When is the right time to stop? Ann Rheum Dis. 63:206–208. 2004.PubMed/NCBI View Article : Google Scholar

3 

Czarnecka-Operacz M and Sadowska-Przytocka A: The possibilities and principles of methotrexate treatment of psoriasis-the updated knowledge. Postepy Dermatol Alergol. 31:392–400. 2014.PubMed/NCBI View Article : Google Scholar

4 

Howard SC, McCormick J, Pui CH, Buddington RK and Harvey RD: Preventing and managing toxicities of high-dose methotrexate. Oncologist. 21:1471–1482. 2016.PubMed/NCBI View Article : Google Scholar

5 

Wiczer T, Dotson E, Tuten A, Phillips G and Maddocks K: Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicity. J Oncol Pharm Pract. 22:430–436. 2016.PubMed/NCBI View Article : Google Scholar

6 

Lateef O, Shakoor N and Balk RA: Methotrexate pulmonary toxicity. Expert Opin Drug Saf. 4:723–730. 2005.PubMed/NCBI View Article : Google Scholar

7 

Kim J, Kim Y, Choi J, Jung H, Lee K, Kang J, Park N, Rim YA, Nam Y and Ju JH: Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis. Stem Cell Res Ther. 9(357)2018.PubMed/NCBI View Article : Google Scholar

8 

Ajmani S, Preet Singh Y, Prasad S, Chowdhury A, Aggarwal A, Lawrence A, Misra R, Mishra R and Agarwal V: Methotrexate-induced pancytopenia: A case series of 46 patients. Int J Rheum Dis. 20:846–851. 2017.PubMed/NCBI View Article : Google Scholar

9 

Driehuis E, Oosterom N, Heil SG, Muller IB, Lin M, Kolders S, Jansen G, de Jonge R, Pieters R, Clevers H and van den Heuvel-Eibrink MM: Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia. PLoS One. 15(e0231588)2020.PubMed/NCBI View Article : Google Scholar

10 

Tang D, Zeng T, Wang Y, Cui H, Wu J, Zou B, Tao Z, Zhang L, Garside GB and Tao S: Dietary restriction increases protective gut bacteria to rescue lethal methotrexate-induced intestinal toxicity. Gut Microbes. 12(1714401)2020.PubMed/NCBI View Article : Google Scholar

11 

Burmester GR, Kaeley GS, Kavanaugh AF, Gabay C, MacCarter DK, Nash P, Takeuchi T, Goss SL, Rodila R, Chen K, et al: Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab. RMD Open. 3(e000465)2017.PubMed/NCBI View Article : Google Scholar

12 

Kroll M, Kaupat-Bleckmann K, Mörickel A, Altenl J, Schewel DM, Stanullal M, Zimmermann M, Schrappe M and Cario G: Methotrexate-associated toxicity in children with Down syndrome and acute lymphoblastic leukemia during consolidation therapy with high dose methotrexate according to ALL-BFM treatment regimen. Haematologica. 105:1013–1020. 2020.PubMed/NCBI View Article : Google Scholar

13 

Naewla S, Sirichoat A, Pannangrong W, Chaisawang P, Wigmore P and Welbat JU: Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats. Nutrients. 11(936)2019.PubMed/NCBI View Article : Google Scholar

14 

Ozcicek F, Kara AV, Akbas EM, Kurt N, Yazici GN, Cankaya M, Mammadov R, Ozcicek A and Suleyman H: Effects of anakinra on the small intestine mucositis induced by methotrexate in rats. Exp Anim. 69:144–152. 2020.PubMed/NCBI View Article : Google Scholar

15 

Widemann BC, Balis FM, Kim A, Boron M, Jayaprakash N, Shalabi A, O Brien M, Eby M, Cole DE, Murphy RF, et al: Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: Clinical and pharmacologic factors affecting outcome. J Clin Oncol. 28:3979–3986. 2010.PubMed/NCBI View Article : Google Scholar

16 

Valade S, Mariotte E, Azoulay E and Darmon M: High-dose methotrexate in ICU patients: A retrospective study. Ann Intensive Care. 10(81)2020.PubMed/NCBI View Article : Google Scholar

17 

Skeoch S, Weatherley N, Swift AJ, Oldroyd A, Johns C, Hayton C, Giollo A, Wild JM, Waterton JC, Buch M, et al: Drug-induced interstitial lung disease: A systematic review. J Clin Med. 10(356)2018.PubMed/NCBI View Article : Google Scholar

18 

Conway R and Carey JJ: Risk of liver disease in methotrexate treated patients. World J Hepatol. 9:92–1100. 2017.PubMed/NCBI View Article : Google Scholar

19 

Elango T, Dayalan H, Gnanaraj P, Malligarjunan H and Subramanian S: Impact of methotrexate on oxidative stress and apoptosis markers in psoriatic patients. Clin Exp Med. 14:431–437. 2013.PubMed/NCBI View Article : Google Scholar

20 

Albrecht K and Muller-Ladner U: Side effects and management of side effects of methotrexate in rheumatoid arthritis. Clin Exp Rheumatol. 28 (5 Suppl 61):S95–S101. 2010.PubMed/NCBI

21 

Pazhayattil GS and Shirali AC: Drug-induced impairment of renal function. Int J Nephrol Renovasc Dis. 7:457–468. 2014.PubMed/NCBI View Article : Google Scholar

22 

Mozaffarian D, Rosenberg I and Uauy R: History of modern nutrition science-implications for current research, dietary guidelines, and food policy. BMJ. 361(k2392)2018.PubMed/NCBI View Article : Google Scholar

23 

Ponmozhi P, Geetha M, Saravana Kumar M and Suganya Devi P: Extraction of anthocyanin and analysing its antioxidant properties from Pithecellobium dulce fruit pericarp. Asian J Pharm Clin Res. 4:41–45. 2011.

24 

Dhanisha SS, Drishya S and Guruvayoorappan C: Fruit extract of Pithecellobium dulce (FPD) ameliorates carrageenan-induced acute inflammatory responses via regulating pro-inflammatory mediators. J Food Biochem. 44(e13329)2020.PubMed/NCBI View Article : Google Scholar

25 

Dhanisha SS, Drishya S and Guruvayoorappan C: Pithecellobium dulce fruit extract mitigates cyclophosphamide-mediated toxicity by regulating proinflammatory cytokines. J Food Biochem. 44(e13083)2020.PubMed/NCBI View Article : Google Scholar

26 

Megala J and Geetha A: Free radical scavenging and H+, K+- ATPase inhibition activities of Pithecellobium dulce. Food Chem. 121:1120–1128. 2010.

27 

Nigam SK, Gopal M, Uddin R, Yoshikawa K, Kawamoto M and Arihara S: Pithedulosides A-G, oleanane glycosides from Pithecellobium dulce. Phytochem. 44:1329–1334. 1997.PubMed/NCBI View Article : Google Scholar

28 

Sahu NP and Mahato SB: Anti-inflammatory triterpene saponins of Pithecellobium dulce: Characterization of an echinocystic acid bisdesmoside. Phytochem. 37:1425–1427. 1994.PubMed/NCBI View Article : Google Scholar

29 

Bautista-Banios S, Garcı́a-Domı́nguez E, Barrera-Necha LL, Reyes Chilpa R and Wilson CL: Seasonal evaluation of the postharvest fungicidal activity of powders and extracts of huamuchil (Pithecellobium dulce): Action against Botrytriscinerea, Penicillium digitatum and Rhizopus stolonifer of strawberry fruit. Postharvest Biol Technol. 29:81–92. 2003.

30 

Dhanisha SS, Drishya S and Guruvayoorappan C: Traditional knowledge to clinical trials: A review on nutritional and therapeutic potential of Pithecellobium dulce. J Basic Clin Physiol Pharmacol: Feb 9, 2021 (Epub ahead of print).

31 

Parekh J and Chanda S: Phytochemical screening of some plants from Western regions of India. Plant Arch. 8:657–662. 2008.

32 

Magalhaes LM, Segundo MA, Reis S and Lima JLFC: Automatic method for determination of total antioxidant capacity using 2,2-diphenyl-1-picrylhydrazyl assay. Analy Chem Acta. 558:310–318. 2006.

33 

McCord MJ and Fridowich I: Superoxide dismutase, an enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 9244:6049–6055. 1969.PubMed/NCBI

34 

Kunchandy E and Rao MNA: Effect of curcumin on hydroxyl radical generation through Fenton reaction. Int J Pharm. 57:173–176. 1989.

35 

Awah FM, Uzoegwu PN, Oyugi JO, Rutherford J, Ifeonu P, Yao X, Fowke KR and Eze MO: Free radical scavenging activity and immunomodulatory effect of Stachytarpheta angustifolia leaf extract. Food Chem. 119:1409–1416. 2010.

36 

Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS and Tannenbaum SR: Analysis of nitrate, nitrite and 15N nitrite in biological fluids. Anal Biochem. 126:131–138. 1982.PubMed/NCBI View Article : Google Scholar

37 

Bishayee S and Balasubramaniyam AS: Lipid peroxide formation in rat brain. J Neurochem. 18:909–920. 1971.PubMed/NCBI View Article : Google Scholar

38 

Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. 1979.PubMed/NCBI View Article : Google Scholar

39 

Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, Sari I and Sagdic O: Role of Grape seed extract on methotrexate induced oxidative stress in rat liver. Am J Chin Med. 36:861–872. 2008.PubMed/NCBI View Article : Google Scholar

40 

Abdel-Daim MM, Khalifa HA, Abushouk AI, Dkhil MA and Al-Quraishy SA: Diosmin attenuates methotrexate-induced hepatic, renal, and cardiac injury: A biochemical and histopathological study in mice. Oxid Med Cell Longev. 2017(3281670)2017.PubMed/NCBI View Article : Google Scholar

41 

Karimi G, Vahabzadeh M, Lari P, Rashedinia M and Moshiri M: Silymarin a promising pharmacological agent for treatment of diseases. Iran J Basic Med sci. 14:308–317. 2011.PubMed/NCBI

42 

Charalampos P, Konstantina L, Olga KM, Panagiotis Z and Vassileia JS: Antioxidant capacity of selected plant extracts and their essential oils. Antioxidants. 2:11–22. 2013.PubMed/NCBI View Article : Google Scholar

43 

Hayash T, Sawa K, Kawasaki M, Arisawa M, Shimizu M and Morita N: Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 51:345–348. 1988.PubMed/NCBI View Article : Google Scholar

44 

Metodiewa D, Kochman A and Karolczak S: Evidence for antiradical and antioxidant properties of four biologically active N,N, diethylaminoethyl ethers of flavanone oximes: A comparison with natural polyphenolic flavonoid (rutin) action. Biochem Mol Biol Int. 41:1067–1075. 1997.PubMed/NCBI View Article : Google Scholar

45 

Havsteen B: The biochemistry and medical significance of the flavonoids. Pharmacol Ther. 96:67–202. 2002.PubMed/NCBI View Article : Google Scholar

46 

Narender PD, Ganga R, Sambasiva E, Mallikarjuna T and Praneeth VS: Quantification of phytochemical constituents and in vitro antioxidant activity of Mesua ferrea leaves. Asian Pac J Trop. 2 (Suppl):S539–S542. 2012.

47 

Hertog MG, Sweetnam PM, Fehily AM, Elwood PC and Kromhout D: Antioxidant flavanols and ischemic heart disease in a welsh population of men: The Caerphilly study. Am J Clin. 65:1489–1494. 1997.PubMed/NCBI View Article : Google Scholar

48 

Kattan MB and Hollman PC: Dietary flavonoids and cardiovascular disease. Nutr Metab Cardiovasc Dis. 81(4)1998.

49 

Badri S, Reddy BV, Basha SK, Anasuya D and Bhavani K: A review on pharmacological activities of alkaloids. World J Curr Med Pharm Res. 1:230–234. 2019.

50 

Arpita R: A review on the alkaloids an important therapeutic compound from plants. Int J Plant Biotechnol. 3:2456–0162. 2017.

51 

Lacaille-Dubois MA and Wagner H: A review of the biological and pharmacological activities of saponins. Phytomed. 2:363–86. 1996.PubMed/NCBI View Article : Google Scholar

52 

Barbosa ADP: An overview on the biological and pharmacological activities of saponins. Int J Pharm Pharm Sci. 6:47–50. 2014.

53 

Rashmi R, Bojan Magesh S, Mohanram Ramkumar K, Suryanarayanan S and Venkata Subba Rao M: Antioxidant potential of naringenin helps to protect liver tissue from streptozotocin-induced damage. Rep Biochem Mol Biol. 7:76–84. 2018.PubMed/NCBI

54 

Xu D, Hu MJ, Wang YQ and Cui YL: Antioxidant activities of quercetin and its complexes for medicinal application. Molecules. 24(1123)2019.PubMed/NCBI View Article : Google Scholar

55 

Bernatoniene J and Kopustinskiene DM: The role of catechins in cellular responses to oxidative stress. Molecules. 23(965)2018.PubMed/NCBI View Article : Google Scholar

56 

Frankel EN: The antioxidant and nutritional effects of tocopherols, ascorbic acid and beta-carotene in relation to processing of edible oils. Bibl Nutr Dieta. 43:297–312. 1989.PubMed/NCBI View Article : Google Scholar

57 

He K, Nukada H, Urakami T and Murphy MP: Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): Implications for its function in biological systems. Biochem Pharmacol. 65:67–74. 2003.PubMed/NCBI View Article : Google Scholar

58 

Velderrain-Rodríguez GR, Torres-Moreno H, Villegas-Ochoa MA, Ayala-Zavala JF, Robles-Zepeda RE, Wall-Medrano A and González-Aguilar GA: Gallic acid content and an antioxidant mechanism are responsible for the antiproliferative activity of ‘Ataulfo' mango peel on LS180 cells. Molecules. 23(695)2018.PubMed/NCBI View Article : Google Scholar

59 

Pushp P, Sharma N, Joseph GS and Singh RP: Antioxidant activity and detection of (-)epicatechin in the methanolic extract of stem of Tinospora cordifolia. J Food Sci Technol. 50:567–572. 2013.PubMed/NCBI View Article : Google Scholar

60 

Gülçin I: Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology. 217:213–220. 2006.PubMed/NCBI View Article : Google Scholar

61 

Henning SM, Niu Y, Liu Y, Lee NH, Hara Y, Thames GD, Minutti RR, Carpenter CL, Wang H and Heber D: Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals. J Nutr Biochem. 16:610–616. 2005.PubMed/NCBI View Article : Google Scholar

62 

Barzegar A: Antioxidant activity of polyphenolic myricetin in vitro cell-free and cell-based systems. Mol Biol Res Commun. 5:87–95. 2016.PubMed/NCBI

63 

Kilic I and Yesilogu Y: Spectroscopic studies on the antioxidant activity of p-coumaric acid. Spectrochim Acta A Mol Biomol Spectrosc. 115:719–724. 2013.PubMed/NCBI View Article : Google Scholar

64 

Kang KA, Piao MJ, Ryu YS, Hyun YJ, Park JE, Shilnikova K, Zhen AX, Kang HK, Koh YS, Jeong YJ and Hyun JW: Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells. Int J Oncol. 51:1169–1178. 2017.PubMed/NCBI View Article : Google Scholar

65 

Salehi B, Venditti A, Sharifi-Rad M, Kręgiel D, Sharifi-Rad J, Durazzo A, Lucarini M, Santini A, Souto EB, Novellino E, et al: The therapeutic potential of apigenin. Int J Mol Sci. 20(1305)2019.PubMed/NCBI View Article : Google Scholar

66 

Chen AY and Chen YC: A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138:2099–2107. 2013.PubMed/NCBI View Article : Google Scholar

67 

Enogieru AB, Haylett W, Hiss DC, Bardien S and Ekpo OE: Rutin as a potent antioxidant: Implications for neurodegenerative disorders. Oxid Med Cell Longev. 2018(6241017)2018.PubMed/NCBI View Article : Google Scholar

68 

Sova M: Antioxidant and antimicrobial activities of cinnamic acid derivatives. Mini Rev Med Chem. 12:749–767. 2021.PubMed/NCBI View Article : Google Scholar

69 

Yang HL, Chen SC, Senthil Kumar KJ, Yu KN, Lee Chao PD, Tsai SY, Hou YC and Hseu YC: Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: An ex vivo approach. J Agric Food Chem. 60:522–532. 2012.PubMed/NCBI View Article : Google Scholar

70 

Sun JY, You CY, Dong K, You HS and Xing JF: Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. Pharm Biol. 54:2282–2287. 2016.PubMed/NCBI View Article : Google Scholar

71 

Park CE, Yun H, Lee EB, Min BI, Bae H, Choe W, Kang I, Kim SS and Ha J: The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells. J Med Food. 13:815–820. 2010.PubMed/NCBI View Article : Google Scholar

72 

Salehi B, Fokou PVT, Sharifi-Rad M, Zucca P, Pezzani R, Martins N and Sharifi-Rad J: The therapeutic potential of naringenin: A review of clinical trials. Pharmaceuticals (Basel). 12(11)2019.PubMed/NCBI View Article : Google Scholar

73 

Baumann J, Wurn G and Bruchlausen FV: Prostaglandin synthetase inhibiting O2 radical scavenging properties of some flavonoids and related phenolic compounds. Arch Pharm Res. 307:1–77. 1979.

74 

Wettasinghe M and Shahidi F: Evening primrose meal: A source of natural antioxidants and scavenger of hydrogen peroxide and oxygen-derived free radicals. J Agric Food Chem. 47:1801–1818. 1999.PubMed/NCBI View Article : Google Scholar

75 

Mohammed AA and Ibrahim AA: Pathological roles of reactive oxygen species and their defence mechanism. Saudi Pharm J. 12:1–18. 2004.

76 

Stohs SJ and Bagchi D: Oxidative mechanisms in the toxicity of metals ions. Free Radic Biol Med. 18:321–336. 1995.PubMed/NCBI View Article : Google Scholar

77 

Lloyd RV, Hanna PM and Mason RP: The origin of the hydroxyl radical oxygen in the fenton reaction. Free Radic Biol Med. 22:885–888. 1997.PubMed/NCBI View Article : Google Scholar

78 

Yin H, Xu L and Porter NA: Free radical lipid peroxidation: Mechanisms and analysis. Chem Rev. 10:5944–5972. 2011.PubMed/NCBI View Article : Google Scholar

79 

Kinnunen PKJ, Kaarniranta K and Mahalka AK: Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations. Biochim Biophys Acta. 10:2446–2455. 2012.PubMed/NCBI View Article : Google Scholar

80 

Reis A and Spickett CM: Chemistry of phospholipid oxidation. Biochim Biophys Acta. 1818:2374–2387. 2012.PubMed/NCBI View Article : Google Scholar

81 

Volinsky R and Kinnunen PK: Oxidized phosphatidylcholines in membrane-level cellular signaling: From biophysics to physiology and molecular pathology. FEBS J. 280:2806–2816. 2013.PubMed/NCBI View Article : Google Scholar

82 

Chiueh CC: Neuroprotective properties of nitric oxide. Ann NY Acad Sci. 890:301–311. 1999.PubMed/NCBI View Article : Google Scholar

83 

Beckman JS and Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol. 271:1424–1437. 1996.PubMed/NCBI View Article : Google Scholar

84 

Welch G and Loscalto J: Nitric oxide and the cardiovascular system. J Cardiothorac Surg. 9:361–371. 1994.PubMed/NCBI View Article : Google Scholar

85 

Hersh EM, Wong VG, Henderson ES and Freirich EJ: Hepatotoxic effects of methotrexate. Cancer. 19:600–606. 1966.PubMed/NCBI View Article : Google Scholar

86 

Hall PD, Jenner MA and Ahern MJ: Hepatotoxicity in a rat model caused by orally administered methotrexate. Hepatol. 14:906–910. 1991.PubMed/NCBI View Article : Google Scholar

87 

Tousson E, Atteya E, El-Atrash E and Jeweely OI: Abrogation by Ginkgo Byloba leaf extract on hepatic and renal toxicity induced by methotrexate in rats. Cancer Res Treat. 2:44–51. 2014.

88 

Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S and Chattopadhyay S: Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways. J Nutr Biochem. 24:2040–2050. 2013.PubMed/NCBI View Article : Google Scholar

89 

Olayinka ET, Ore A, Adeyemo OA and Ola OS: Ameliorative effect of gallic acid on methotrexate-induced hepatotoxicity and nephrotoxicity in rat. J Xenobiot. 6(6092)2016.PubMed/NCBI View Article : Google Scholar

90 

Saka S and Aouacheri O: The investigation of the oxidative stress-related parameters in high the investigation of the oxidative stress-related parameters in high doses methotrexate-induced albino wistar rats. J Bioequiv Availab. 9(2)2017.

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Dhanisha SS, Drishya S, Mony RP and Guruvayoorappan C: Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines. Int J Funct Nutr 2: 7, 2021.
APA
Dhanisha, S.S., Drishya, S., Mony, R.P., & Guruvayoorappan, C. (2021). Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines. International Journal of Functional Nutrition, 2, 7. https://doi.org/10.3892/ijfn.2021.17
MLA
Dhanisha, S. S., Drishya, S., Mony, R. P., Guruvayoorappan, C."Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines". International Journal of Functional Nutrition 2.3 (2021): 7.
Chicago
Dhanisha, S. S., Drishya, S., Mony, R. P., Guruvayoorappan, C."Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines". International Journal of Functional Nutrition 2, no. 3 (2021): 7. https://doi.org/10.3892/ijfn.2021.17
Copy and paste a formatted citation
x
Spandidos Publications style
Dhanisha SS, Drishya S, Mony RP and Guruvayoorappan C: Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines. Int J Funct Nutr 2: 7, 2021.
APA
Dhanisha, S.S., Drishya, S., Mony, R.P., & Guruvayoorappan, C. (2021). Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines. International Journal of Functional Nutrition, 2, 7. https://doi.org/10.3892/ijfn.2021.17
MLA
Dhanisha, S. S., Drishya, S., Mony, R. P., Guruvayoorappan, C."Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines". International Journal of Functional Nutrition 2.3 (2021): 7.
Chicago
Dhanisha, S. S., Drishya, S., Mony, R. P., Guruvayoorappan, C."Polyphenolic‑rich fraction of <em>Pithecellobium dulce</em> attenuates methotrexate‑induced oxidative stress and associated tissue injury by regulating the TNF‑α, IL‑1β and IL‑6 pro‑inflammatory cytokines". International Journal of Functional Nutrition 2, no. 3 (2021): 7. https://doi.org/10.3892/ijfn.2021.17
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team