Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

Tang,Shuangfeng; Liu,Jiayue; Xu,Caiming; Shang,Dong; Chen,Hailong; Zhang,Guixin

doi:10.3892/ijfn.2021.22

Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

Authors:
- Shuangfeng Tang
- Jiayue Liu
- Caiming Xu
- Dong Shang
- Hailong Chen
- Guixin Zhang
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Affiliations: Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
Published online on: November 18, 2021 https://doi.org/10.3892/ijfn.2021.22
Article Number: 12
Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intra‑abdominal infections (IAIs) are one of the most common critical diseases in clinical practice, with high morbidity and mortality rates. A variety of abdominal diseases can lead to abdominal infection, such as acute appendicitis, acute cholecystitis, various causes of gastrointestinal perforation, post‑operative complications and trauma. It has been demonstrated that probiotics are of utmost significance in improving the treatment and prognosis of patients with IAIs. Probiotics play a beneficial role in the host's metabolism, immunity and nervous system by interacting with the host microorganisms, preventing the colonization of pathogens, improving intestinal barrier function, regulating immune function and producing related metabolites. The aim of the present review article was to discuss and summarize the regulatory effect of probiotics on intestinal barrier dysfunction and immunological imbalance in IAIs, in order to provide a foundation for the development of novel therapeutic approaches and disease prevention measures.

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