Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Functional Nutrition
Join Editorial Board Propose a Special Issue
Print ISSN: 2634-7989 Online ISSN: 2634-7237
Journal Cover
January-February 2022 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2022 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)

  • Authors:
    • Xia Qiu
    • Fahe Wang
    • Yimin Qin
    • Zhanyi Sun
    • Peili Shen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Bioactive Seaweed Substances, Qingdao Bright Moon Seaweed Group Co., Ltd., Qingdao, Shandong 266400, P.R. China
    Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1
    |
    Published online on: December 27, 2021
       https://doi.org/10.3892/ijfn.2021.24
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

The intestinal tract is one of the main organs responsible for digestion and absorption, and it also functions as a congenital barrier to maintain the homeostasis of the internal environment of the body. Damage to the intestinal mucosal barrier is closely related to the occurrence and development of a variety of diseases. As a natural food product, fucoidan has a number of biological activities. In recent years, it has been found that it exerts certain protective effects on intestinal physical, chemical, immune and microbial barriers. In the present review article, the role and mechanisms of action of fucoidan in protecting the intestinal mucosal barrier from damage are summarized and discussed. It is hoped that the information presented herein, may shed light onto the functions of fucoidan and may aid its use as a protective strategy against intestinal mucosal barrier dysfunction.
View Figures

Figure 1

View References

1 

Ma X, Dai Z, Sun K, Zhang Y, Chen J, Yang Y, Tso P, Wu G and Wu Z: Intestinal epithelial cell endoplasmic reticulum stress and inflammatory bowel disease pathogenesis: An update review. Front Immunol. 8:1271–1273. 2017.PubMed/NCBI View Article : Google Scholar

2 

Blikslager AT, Moeser AJ, Gookin JL, Jones SL and Odle J: Restoration of barrier function in injured intestinal mucosa. Physiol Rev. 87:545–564. 2007.PubMed/NCBI View Article : Google Scholar

3 

Li B, Lu F, Wei X and Zhao R: Fucoidan: Structure and bioactivity. Molecules. 13:1671–1695. 2008.PubMed/NCBI View Article : Google Scholar

4 

Anastyuk SD, Imbs TI, Shevchenko NM, Dmitrenok PS and Zvyagintseva TN: ESIMS analysis of fucoidan preparations from Costaria costata, extracted from alga at different life-stages. Carbohydr Polym. 90:993–1002. 2012.PubMed/NCBI View Article : Google Scholar

5 

Usoltseva RV, Anastyuk SD, Ishina IA, Isakov VV, Zvyagintseva TN, Thinh PD, Zadorozhny PA, Dmitrenok PS and Ermakova SP: Structural characteristics and anticancer activity in vitro of fucoidan from brown alga Padina boryana. Carbohydr Polym. 184:260–268. 2018.PubMed/NCBI View Article : Google Scholar

6 

Wu L, Sun J, Su X, Yu Q, Yu Q and Zhang P: A review about the development of fucoidan in antitumor activity: Progress and challenges. Carbohydr Polym. 154:96–111. 2016.PubMed/NCBI View Article : Google Scholar

7 

Zuo T, Li X, Chang Y, Duan G, Yu L, Zheng R, Xue C and Tang Q: Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice. Food Funct. 6:415–422. 2015.PubMed/NCBI View Article : Google Scholar

8 

Matayoshi M, Teruya J, Yasumoto-Hirose M, Teruya R, Miura N and Takeda R: Improvement of defecation in healthy individuals with infrequent bowel movements through the ingestion of dried Mozuku powder: A randomized, double-blind, parallel-group study. Funct Foods Health Dis. 7:735–742. 2017.

9 

Shi H, Chang Y, Gao Y, Wang X, Chen X, Wang Y, Xue C and Tang Q: Dietary fucoidan of Acaudina molpadioides alters gut microbiota and mitigates intestinal mucosal injury induced by cyclophosphamide. Food Funct. 8:3383–3393. 2017.PubMed/NCBI View Article : Google Scholar

10 

Xue M, Ji X, Liang H, Liu Y, Wang B, Sun L and Li W: The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer. Food Funct. 9:1214–1223. 2018.PubMed/NCBI View Article : Google Scholar

11 

Wang Y, Huang D, Chen KY, Cui M, Wang W, Huang X, Awadellah A, Li Q, Friedman A, Xin WW, et al: Fucosylation deficiency in mice leads to colitis and adenocarcinoma. Gastroenterology. 152:193–205. 2017.PubMed/NCBI View Article : Google Scholar

12 

Liu HJ, Li HT, Lin Y, Lu DL, Yue Y, Xiong J, Li CQ, Xu XY and Feng YG: Identification of 2 potential core genes for influence of gut probiotics on formation of intracranial aneurysms by bioinformatics analysis. Med Sci Monit. 26(e920754)2020.PubMed/NCBI View Article : Google Scholar

13 

Shang Q, Shan X, Cai C, Hao J, Li G and Yu G: Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae. Food Funct. 7:3224–3232. 2016.PubMed/NCBI View Article : Google Scholar

14 

O'Shea CJ, O'Doherty JV, Callanan JJ, Doyle D, Thornton K and Sweeney T: The effect of algal polysaccharides laminarin and fucoidan on colonic pathology, cytokine gene expression and Enterobacteriaceae in a dextran sodium Sulfate-challenged porcine model. J Nutr Sci. 5(e15)2016.PubMed/NCBI View Article : Google Scholar

15 

Park J, Cha JD, Choi KM, Lee KY, Han KM and Jang YS: Fucoidan inhibits LPS-induced inflammation in vitro and during the acute response in vivo. Int Immunopharmacol. 43:91–98. 2017.PubMed/NCBI View Article : Google Scholar

16 

Sun T, Liang H, Xue ML, Liu Y, Gong A, Jiang Y, Qin Y, Yang J and Meng D: Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice. Food Agr Immunol. 31:922–936. 2020.

17 

Okolie CL, Rajendran SRCK, Udenigwe CC, Aryee ANA and Maso B: Prospects of brown seaweed polysaccharides (BSP) as prebiotics and potential immunomodulators. J Food Biochemistry. 7(e12392)2017.

18 

Chen SH, Zhao Y, Zhang Y and Zhang D: Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PLoS One. 9(e108157)2014.PubMed/NCBI View Article : Google Scholar

19 

Kan J, Cheng J, Xu L, Hood M, Zhong D, Cheng M, Liu Y, Chen L and Du J: The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: A double-blinded, placebo-controlled study. Eur J Nutr. 59:1655–1666. 2020.PubMed/NCBI View Article : Google Scholar

20 

Liu M, Ma L, Chen Q, Zhang P, Chen C, Jia L and Li H: Fucoidan alleviates dyslipidemia and modulates gut microbiota in high-fat diet-induced mice. J Funct Foods. 48:220–227. 2018.

21 

Chen Q, Liu M, Zhang P, Fan S, Huang J, Yu S, Zhang C and Li H: Fucoidan and galactooligosaccharides ameliorate high-fat diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism. Nutrition. 65:50–59. 2019.PubMed/NCBI View Article : Google Scholar

22 

Blandino G, Inturri R, Lazzara F, Di Rosa M and Malaguarnera L: Impact of gut microbiota on diabetes mellitus. Diabetes Metab. 42:303–315. 2016.PubMed/NCBI View Article : Google Scholar

23 

Shang Q, Song G, Zhang M, Shi J, Xu C, Hao J, Li G and Yu G: Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice. J Funct Foods. 28:138–146. 2017.

24 

Zhang J, Ankawi G, Sun J, Digvijay K, Yin Y, Rosner MH and Ronco C: Gut-kidney crosstalk in septic acute kidney injury. Crit Care. 22:117–120. 2018.PubMed/NCBI View Article : Google Scholar

25 

Kadena K, Tomori M, Iha M and Nagamine T: Absorption study of Mozuku fucoidan in Japanese volunteers. Mar Drugs. 16:254–258. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Qiu X, Wang F, Qin Y, Sun Z and Shen P: Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review). Int J Funct Nutr 3: 1, 2022.
APA
Qiu, X., Wang, F., Qin, Y., Sun, Z., & Shen, P. (2022). Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review). International Journal of Functional Nutrition, 3, 1. https://doi.org/10.3892/ijfn.2021.24
MLA
Qiu, X., Wang, F., Qin, Y., Sun, Z., Shen, P."Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)". International Journal of Functional Nutrition 3.1 (2022): 1.
Chicago
Qiu, X., Wang, F., Qin, Y., Sun, Z., Shen, P."Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)". International Journal of Functional Nutrition 3, no. 1 (2022): 1. https://doi.org/10.3892/ijfn.2021.24
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu X, Wang F, Qin Y, Sun Z and Shen P: Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review). Int J Funct Nutr 3: 1, 2022.
APA
Qiu, X., Wang, F., Qin, Y., Sun, Z., & Shen, P. (2022). Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review). International Journal of Functional Nutrition, 3, 1. https://doi.org/10.3892/ijfn.2021.24
MLA
Qiu, X., Wang, F., Qin, Y., Sun, Z., Shen, P."Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)". International Journal of Functional Nutrition 3.1 (2022): 1.
Chicago
Qiu, X., Wang, F., Qin, Y., Sun, Z., Shen, P."Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)". International Journal of Functional Nutrition 3, no. 1 (2022): 1. https://doi.org/10.3892/ijfn.2021.24
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team