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Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia

  • Authors:
    • Annia Tsolakou
    • Natalia Papakonstantinou
    • Dimitrios Konstantinidis
    • Christos Papanikolaou
    • Panagiotis Diamantakos
    • Vasiliki Economou
    • Eleni Melliou
    • Costas P. Tsioufis
    • Prokopios Magiatis
    • Nikolaos Drakoulis
  • View Affiliations / Copyright

    Affiliations: Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece, First Cardiology Clinic, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
    Copyright: © Tsolakou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 3
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    Published online on: February 20, 2025
       https://doi.org/10.3892/ijfn.2025.44
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Abstract

 The present study investigated the effects of a nutritional supplement derived from high‑phenolic Kalamon variety table olives on lipid parameters in individuals with mild dyslipidemia. The supplement, which corresponds to the consumption of five table olives daily, was produced through a process involving the removal of olive oil, the extraction of tyrosol, hydroxytyrosol and lactic acid, and the removal of water and salt. In a 30‑day clinical analysis, volunteers with mild dyslipidemia were enrolled and instructed to take two capsules daily, while maintaining a healthy lifestyle and diet. The results revealed significant reductions in total cholesterol (4.16%) and low‑density lipoprotein (LDL) cholesterol (5.67%) levels following supplementation. Although the triglyceride levels exhibited a modest reduction, the difference in these levels did not reach statistical significance. High‑density lipoprotein cholesterol levels were not affected throughout the study period. The individualized responses to supplementation were observed in all lipid parameters, with varying ranges in initial and final measurements among the participants. These findings suggest that the nutritional supplement may have beneficial effects on reducing total cholesterol and LDL cholesterol levels, highlighting the potential health benefits of the phenolic compounds found in table olives, particularly hydroxytyrosol and tyrosol, related to cardiovascular well‑being and metabolic health. However, further research is required to confirm these results and investigate the underlying mechanisms.
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Copy and paste a formatted citation
Spandidos Publications style
Tsolakou A, Papakonstantinou N, Konstantinidis D, Papanikolaou C, Diamantakos P, Economou V, Melliou E, Tsioufis CP, Magiatis P, Drakoulis N, Drakoulis N, et al: Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia. Int J Funct Nutr 6: 3, 2025.
APA
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V. ... Drakoulis, N. (2025). Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia. International Journal of Functional Nutrition, 6, 3. https://doi.org/10.3892/ijfn.2025.44
MLA
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V., Melliou, E., Tsioufis, C. P., Magiatis, P., Drakoulis, N."Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia". International Journal of Functional Nutrition 6.1 (2025): 3.
Chicago
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V., Melliou, E., Tsioufis, C. P., Magiatis, P., Drakoulis, N."Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia". International Journal of Functional Nutrition 6, no. 1 (2025): 3. https://doi.org/10.3892/ijfn.2025.44
Copy and paste a formatted citation
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Spandidos Publications style
Tsolakou A, Papakonstantinou N, Konstantinidis D, Papanikolaou C, Diamantakos P, Economou V, Melliou E, Tsioufis CP, Magiatis P, Drakoulis N, Drakoulis N, et al: Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia. Int J Funct Nutr 6: 3, 2025.
APA
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V. ... Drakoulis, N. (2025). Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia. International Journal of Functional Nutrition, 6, 3. https://doi.org/10.3892/ijfn.2025.44
MLA
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V., Melliou, E., Tsioufis, C. P., Magiatis, P., Drakoulis, N."Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia". International Journal of Functional Nutrition 6.1 (2025): 3.
Chicago
Tsolakou, A., Papakonstantinou, N., Konstantinidis, D., Papanikolaou, C., Diamantakos, P., Economou, V., Melliou, E., Tsioufis, C. P., Magiatis, P., Drakoulis, N."Reduction of LDL and total cholesterol levels with Kalamon table olive extract: A natural approach to dyslipidemia". International Journal of Functional Nutrition 6, no. 1 (2025): 3. https://doi.org/10.3892/ijfn.2025.44
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