A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer.

  • Authors:
    • M Maeta
    • H Saito
    • K Katano
    • A Kondo
    • S Tsujitani
    • M Makino
    • M Ikeguchi
    • N Kaibara
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijmm.1.1.113
  • Pages: 113-119
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Activated T lymphocytes release a soluble form of IL-2R (SoIL-2R) into the bloodstream, which can be detected by CD25 monoclonal antibody. Perioperative changes of serum levels of SoIL-2R and the number of CD25-positive cells were monitored simultaneously to clarify the clinical implications of SoIL-2R in patients with gastric cancer (n=91). Preoperative levels of SoIL-2R were significantly higher than in normal controls and levels were a useful indicator of possible lymph node involvement. Postoperative levels of SoIL-2R increased independently of the number of CD25-positive cells. Patients with progressive postoperative increases in levels of SoIL-2R had both a significantly high frequency of postoperative relapse and a poor prognosis. Increased SoIL-2R may reduce the availability of IL-2 by binding to it. Postoperative progressive increases in SoIL-2R appear to be a good indicator for a poor prognosis in patients with gastric cancer.

Related Articles

Journal Cover

Jan 1998
Volume 1 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Maeta M, Saito H, Katano K, Kondo A, Tsujitani S, Makino M, Ikeguchi M and Kaibara N: A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer.. Int J Mol Med 1: 113-119, 1998
APA
Maeta, M., Saito, H., Katano, K., Kondo, A., Tsujitani, S., Makino, M. ... Kaibara, N. (1998). A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer.. International Journal of Molecular Medicine, 1, 113-119. https://doi.org/10.3892/ijmm.1.1.113
MLA
Maeta, M., Saito, H., Katano, K., Kondo, A., Tsujitani, S., Makino, M., Ikeguchi, M., Kaibara, N."A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer.". International Journal of Molecular Medicine 1.1 (1998): 113-119.
Chicago
Maeta, M., Saito, H., Katano, K., Kondo, A., Tsujitani, S., Makino, M., Ikeguchi, M., Kaibara, N."A progressive postoperative increase in the serum level of soluble receptors for interleukin-2 is an indicator of a poor prognosis in patients with gastric cancer.". International Journal of Molecular Medicine 1, no. 1 (1998): 113-119. https://doi.org/10.3892/ijmm.1.1.113