Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).

  • Authors:
    • K Hatake
    • H Tomizuka
    • M Ikeda
    • Y Terui
    • Y Miura
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijmm.1.1.121
  • Pages: 121-130
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Abstract

Gene expression involving apoptosis in the hematopoietic system is reviewed. In normal and hematological disorders, Fas-Fas ligand and tumor necrosis factor-alpha-receptor interaction play a major role in enhancing apoptosis. On the other hand, bcl-2 or certain novel proteins (including FADD, RIP, TRADD and sentrin) prevent apoptosis. Apoptosis is involved in myelodysplastic syndrome and pathogenesis of leukemia. Expression of Fas antigen plays a role in negative regulation of hematopoiesis in the bone marrow as does interferon-gamma.

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Jan 1998
Volume 1 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hatake K, Tomizuka H, Ikeda M, Terui Y and Miura Y: Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).. Int J Mol Med 1: 121-130, 1998
APA
Hatake, K., Tomizuka, H., Ikeda, M., Terui, Y., & Miura, Y. (1998). Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).. International Journal of Molecular Medicine, 1, 121-130. https://doi.org/10.3892/ijmm.1.1.121
MLA
Hatake, K., Tomizuka, H., Ikeda, M., Terui, Y., Miura, Y."Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).". International Journal of Molecular Medicine 1.1 (1998): 121-130.
Chicago
Hatake, K., Tomizuka, H., Ikeda, M., Terui, Y., Miura, Y."Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).". International Journal of Molecular Medicine 1, no. 1 (1998): 121-130. https://doi.org/10.3892/ijmm.1.1.121