Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.

  • Authors:
    • T Kato
    • M Daimon
    • J Suzuki
    • H Sasaki
    • K Ishikawa
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijmm.1.1.63
  • Pages: 63-69
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We have previously reported that antibodies against HIV-1p17 protein cross-react with human superoxide dismutase-2 (SOD-2). To identify and characterize the epitopes of human SOD-2 recognized by anti-HIV-1p17 antibody, we synthesized several peptide fragments of human SOD-2 and found that the antibody did not bind to the LQPALK hexapeptide which is contained in both HIV-1p17 and human SOD-2. Instead, this antibody bound to four peptides which contain amino acid sequences similar, but not identical, to the known epitopes of HIV-1p17. These peptides have two features in three-dimensional (3-D) conformation: two protruded carbohydrate side chains on the peptide chain or a concave structure in the molecule. It is suggested that the antibody does not strictly recognize the amino acid sequence itself, but may recognize these 3-D conformations.

Related Articles

Journal Cover

Jan 1998
Volume 1 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kato T, Daimon M, Suzuki J, Sasaki H and Ishikawa K: Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.. Int J Mol Med 1: 63-69, 1998.
APA
Kato, T., Daimon, M., Suzuki, J., Sasaki, H., & Ishikawa, K. (1998). Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.. International Journal of Molecular Medicine, 1, 63-69. https://doi.org/10.3892/ijmm.1.1.63
MLA
Kato, T., Daimon, M., Suzuki, J., Sasaki, H., Ishikawa, K."Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.". International Journal of Molecular Medicine 1.1 (1998): 63-69.
Chicago
Kato, T., Daimon, M., Suzuki, J., Sasaki, H., Ishikawa, K."Three-dimensional conformation of the epitopes of human superoxide dismutase-2 recognized by antibody against HIV-1p17.". International Journal of Molecular Medicine 1, no. 1 (1998): 63-69. https://doi.org/10.3892/ijmm.1.1.63