Determination of p53 protein and high-risk human papillomavirus DNA in carcinomas of the renal pelvis and ureter.

Kuwahara,M; Fujisaki,N; Kagawa,S; Furihata,M; Ohtsuki,Y

doi:10.3892/ijmm.1.4.703

Apr 1998 Volume 1 Issue 4

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Apr 1998 Volume 1 Issue 4

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Article

Determination of p53 protein and high-risk human papillomavirus DNA in carcinomas of the renal pelvis and ureter.

Authors:
- M Kuwahara
- N Fujisaki
- S Kagawa
- M Furihata
- Y Ohtsuki
View Affiliations / Copyright

Affiliations: Department of Urology, Fujisaki Hospital, Karatsu, Saga 847, Japan.
Pages: 703-710
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Published online on: April 1, 1998

https://doi.org/10.3892/ijmm.1.4.703
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Abstract

The presence and distribution of high-risk human papillomavirus (HPV) DNA type-16 and -18 or overexpression of the p53 protein were determined in 31 patients with renal pelvic and ureteral carcinoma in Saga prefecture of Japan, consisting of 28 transitional cell carcinomas (TCCs) and 3 squamous cell carcinomas (SCCs). In situ hybridization with DNA probes for HPV-16 and -18 was performed as well as immunohistochemical techniques using antibody to p53 protein. Fresh tumor tissues from 8 patients were also studied for p53 mutations in exons 5 through 8 by direct sequencing. Of 28 TCC patients at Saga prefecture in Japan, 10 tested were positive for HPV DNA, 5 for HPV type-16, 4 for HPV type-18 and one doubly-positive case. Of the remaining 18 tumors, seven showed positive nuclear staining in cancer cells with p53 antibody. One of the 3 patients with SCCs also revealed the nuclear positivity of the cancer cells with p53 antibody but not with HPV infection. p53 point mutation was detected in 2 cases also showing p53 immunopositivity. Overexpressed p53 protein was statistically more common in invasive and non-papillary (p<0.05) and in high-grade TCCs (p<0.05). These findings suggest that HPV infection, and expression (mutation) of p53 protein may be intimately related to the pathogenesis of urothelial tumor cell growth and progression.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Determination of p53 protein and high-risk human papillomavirus DNA in carcinomas of the renal pelvis and ureter.

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Abstract

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