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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 1998 Volume 1 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1998 Volume 1 Issue 5

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Article

Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).

  • Authors:
    • O Reiner
    • T Sapir
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel.
  • Pages: 849-902
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/ijmm.1.5.849
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Abstract

Lissencephaly is a relatively common brain malformation. Lissencephaly type 1 is characterized by the smooth appearance of the cortex and the presence of four abnormally positioned layers instead of the normal six. Lissencephaly is considered to be an abnormality in neuronal migration. The gene mutated in type 1 lissencephaly was cloned by us and designated LIS1. Recently, several genes involved in cortical development have been cloned in the mouse. In human an additional X-linked lissencephaly gene has been identified. We summarize here our current knowledge on the LIS1 gene and its function. It has been identified as a non-catalytic subunit of PAF-acetylhydrolase, a heterotrimeric enzyme which inactivates the platelet-activating factor (PAF). In addition, we have demonstrated that LIS1 interacts with tubulin, and affects the dynamics properties of microtubles. LIS1 contains seven WD repeats and may structurally resemble the beta-subunit of heterotrimeric G proteins. Interestingly, the catalytic subunit of PAF-acetylhydrolase was found to resemble the alpha subunit of heterotrimeric G proteins. We raise the possibility that LIS1 is part of an intracellular signaling pathway involved in neuronal migration.

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Copy and paste a formatted citation
Spandidos Publications style
Reiner O and Sapir T: Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).. Int J Mol Med 1: 849-902, 1998.
APA
Reiner, O., & Sapir, T. (1998). Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).. International Journal of Molecular Medicine, 1, 849-902. https://doi.org/10.3892/ijmm.1.5.849
MLA
Reiner, O., Sapir, T."Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).". International Journal of Molecular Medicine 1.5 (1998): 849-902.
Chicago
Reiner, O., Sapir, T."Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).". International Journal of Molecular Medicine 1, no. 5 (1998): 849-902. https://doi.org/10.3892/ijmm.1.5.849
Copy and paste a formatted citation
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Spandidos Publications style
Reiner O and Sapir T: Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).. Int J Mol Med 1: 849-902, 1998.
APA
Reiner, O., & Sapir, T. (1998). Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).. International Journal of Molecular Medicine, 1, 849-902. https://doi.org/10.3892/ijmm.1.5.849
MLA
Reiner, O., Sapir, T."Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).". International Journal of Molecular Medicine 1.5 (1998): 849-902.
Chicago
Reiner, O., Sapir, T."Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).". International Journal of Molecular Medicine 1, no. 5 (1998): 849-902. https://doi.org/10.3892/ijmm.1.5.849
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