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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 1998 Volume 1 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1998 Volume 1 Issue 5

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Article

Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.

  • Authors:
    • P E Leone
    • M J Bello
    • M Mendiola
    • M E Kusak
    • J M De Campos
    • J Vaquero
    • J L Sarasa
    • A Pestana
    • J A Rey

  • View Affiliations / Copyright

    Affiliations: Instituto de Investigaciones Biomedicas (CSIC), Madrid, Spain.
  • Pages: 889-981
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/ijmm.1.5.889
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Abstract

Schwannomas are common benign tumours of schwann cell origin, frequently found in patients with neurofibromatosis type 2 (NF2). Inactivation of the NF2 tumour suppressor gene appears to be a molecular event responsible for the development of up to 60% of cases, but no data are available on other superimposed secondary or alternative molecular abnormalities in those schwannomas lacking NF2 gene inactivation. We analysed 23 sporadic schwannomas for mutations in the NF2 gene and for the allelic status at 1p, 14q and 22q, as alterations of these genomic regions appear to be related to tumour progression in meningiomas, another NF2-associated neoplasm. Nine samples displayed allelic losses for markers on chromosome 22, and deletions at 1p were detected in two. No case showed losses for 14q. Three tumours displayed NF2 gene mutations, at exons 2, 7 and 12. Our results confirm that inactivation of the NF2 gene is a primary event in schwannoma development, and provide data suggesting that allelic loss at 1p may contribute to the pathogenesis of a small subgroup of this histological tumour type.

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Copy and paste a formatted citation
Spandidos Publications style
Leone P, Bello M, Mendiola M, Kusak M, De Campos J, Vaquero J, Sarasa J, Pestana A and Rey J: Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.. Int J Mol Med 1: 889-981, 1998.
APA
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J. ... Rey, J. (1998). Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.. International Journal of Molecular Medicine, 1, 889-981. https://doi.org/10.3892/ijmm.1.5.889
MLA
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J., Sarasa, J., Pestana, A., Rey, J."Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.". International Journal of Molecular Medicine 1.5 (1998): 889-981.
Chicago
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J., Sarasa, J., Pestana, A., Rey, J."Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.". International Journal of Molecular Medicine 1, no. 5 (1998): 889-981. https://doi.org/10.3892/ijmm.1.5.889
Copy and paste a formatted citation
x
Spandidos Publications style
Leone P, Bello M, Mendiola M, Kusak M, De Campos J, Vaquero J, Sarasa J, Pestana A and Rey J: Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.. Int J Mol Med 1: 889-981, 1998.
APA
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J. ... Rey, J. (1998). Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.. International Journal of Molecular Medicine, 1, 889-981. https://doi.org/10.3892/ijmm.1.5.889
MLA
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J., Sarasa, J., Pestana, A., Rey, J."Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.". International Journal of Molecular Medicine 1.5 (1998): 889-981.
Chicago
Leone, P., Bello, M., Mendiola, M., Kusak, M., De Campos, J., Vaquero, J., Sarasa, J., Pestana, A., Rey, J."Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.". International Journal of Molecular Medicine 1, no. 5 (1998): 889-981. https://doi.org/10.3892/ijmm.1.5.889
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