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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Jun 1998 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.

  • Authors:
    • L Ladriere
    • M M Kadiata
    • W J Malaisse
  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium.
  • Pages: 967-1037
    |
    Published online on: June 1, 1998
       https://doi.org/10.3892/ijmm.1.6.967
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Abstract

D-mannoheptulose, which inhibits hexokinase isoenzymes in a predominantly competitive manner, has been found to decrease much more modestly D-glucose metabolism in pancreatic islets exposed to a low, as distinct from high, concentration of the hexose. In the present study, which aimed at investigating the factor(s) possibly responsible for such a phenomenon, a comparable situation was found to prevail in rat hepatocytes. However, when the hexaacetate ester of D-mannoheptulose was used instead of the unesterified heptose, the relative extent of inhibition of D-[5-3H]glucose utilization and D-[U-14C]glucose conversion to 14C-labelled acidic metabolites was comparable in hepatocytes exposed to either 1.7 or 8.3 mM D-glucose. Moreover, at the low D-glucose level, the incorporation of 3-O-methyl-D-glucose (6.6 mM) into the incubation medium increased the inhibitory action of unesterified D-mannoheptulose upon D-glucose metabolism. These findings suggest that an insufficient uptake of the heptose accounts, in part at least, for its poor efficiency as inhibitor of D-glucose catabolism in liver, and presumably islet cells exposed to low concentrations of the hexose.

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Copy and paste a formatted citation
Spandidos Publications style
Ladriere L, Kadiata M and Malaisse W: Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.. Int J Mol Med 1: 967-1037, 1998.
APA
Ladriere, L., Kadiata, M., & Malaisse, W. (1998). Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.. International Journal of Molecular Medicine, 1, 967-1037. https://doi.org/10.3892/ijmm.1.6.967
MLA
Ladriere, L., Kadiata, M., Malaisse, W."Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.". International Journal of Molecular Medicine 1.6 (1998): 967-1037.
Chicago
Ladriere, L., Kadiata, M., Malaisse, W."Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.". International Journal of Molecular Medicine 1, no. 6 (1998): 967-1037. https://doi.org/10.3892/ijmm.1.6.967
Copy and paste a formatted citation
x
Spandidos Publications style
Ladriere L, Kadiata M and Malaisse W: Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.. Int J Mol Med 1: 967-1037, 1998.
APA
Ladriere, L., Kadiata, M., & Malaisse, W. (1998). Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.. International Journal of Molecular Medicine, 1, 967-1037. https://doi.org/10.3892/ijmm.1.6.967
MLA
Ladriere, L., Kadiata, M., Malaisse, W."Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.". International Journal of Molecular Medicine 1.6 (1998): 967-1037.
Chicago
Ladriere, L., Kadiata, M., Malaisse, W."Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes.". International Journal of Molecular Medicine 1, no. 6 (1998): 967-1037. https://doi.org/10.3892/ijmm.1.6.967
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