G-CSF: function and modes of action (Review)

  • Authors:
    • Sunanda Basu
    • Ashley Dunn
    • Alister Ward
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/ijmm.10.1.3
  • Pages: 3-10
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Abstract

Since the observations in the 1960s that granulocyte-colony stimulating factor (G-CSF) stimulated the proliferation of granulocytic cells in semisolid cultures of bone marrow cells, G-CSF has established itself as a useful clinical agent for increasing levels of neutrophilic granulocytes. However, these early findings did not firmly establish whether G-CSF is a genuine regulator of granulocyte formation under normal physiological conditions or rather acts as an emergency regulator, playing an important role only under stress conditions. The advent of has allowed us to evaluate these questions in a physiological setting through analysis of mice with a targeted mutation of G-CSF or its receptor, while the development of relevant cell models has enabled us to dissect the molecular basis of G-CSF action. This review discusses our current state of knowledge regarding the role of G-CSF in granulopoiesis.

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July 2002
Volume 10 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Basu S, Dunn A and Ward A: G-CSF: function and modes of action (Review). Int J Mol Med 10: 3-10, 2002
APA
Basu, S., Dunn, A., & Ward, A. (2002). G-CSF: function and modes of action (Review). International Journal of Molecular Medicine, 10, 3-10. https://doi.org/10.3892/ijmm.10.1.3
MLA
Basu, S., Dunn, A., Ward, A."G-CSF: function and modes of action (Review)". International Journal of Molecular Medicine 10.1 (2002): 3-10.
Chicago
Basu, S., Dunn, A., Ward, A."G-CSF: function and modes of action (Review)". International Journal of Molecular Medicine 10, no. 1 (2002): 3-10. https://doi.org/10.3892/ijmm.10.1.3