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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2002 Volume 10 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands

  • Authors:
    • Piera Rebuffat
    • Myriam L. Forneris
    • Carlo Macchi
    • Ludwik K. Malendowicz
    • Marcin Trejter
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I-35121 Padua, Italy;
  • Pages: 85-88
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijmm.10.1.85
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Abstract

Evidence has been provided that adrenomedullin (ADM) stimulates the proliferative activity of adult rat adrenal zona glomerulosa (ZG). However, the selective ADM receptor antagonist ADM22-52, although being able to block ADM effect, was per se ineffective. In contrast, in the companion paper, we showed that ADM22-52 depresses the proliferation rate of ZG in 20-day-old rats, suggesting the involvement of endogenous ADM system in adrenal maturation. Hence, we investigated by semiquantitative reverse transcription-polymerase chain reaction and radioimmune assay the expression of ADM system in adult and immature rat ZG. ProADM mRNA and ADM-immunoreactivity were both more elevated in immature- than adult-rat ZG. Plasma ADM concentration did not show significant age-related differences. ADM acts via two subtypes of ADM22-52-sensitive receptors: the L1 receptor (L1-R) and the calcitonin-receptor-like-receptor (CRLR), the latter behaves as selective ADM receptor only in the presence of the receptor-activity-modifying proteins (RAMPs)2 and 3. L1-R expression was enhanced in immature rat ZG, while CRLR and RAMP2,3 expression did not display significant differences. It is concluded that the endogenous ADM system located in the ZG is upregulated in immature rats, and plays an important autocrine-paracrine role in the maintenance of the elevated growth rate during adrenal maturation.

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Copy and paste a formatted citation
Spandidos Publications style
Rebuffat P, Forneris ML, Macchi C, Malendowicz LK, Trejter M and Nussdorfer GG: Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands. Int J Mol Med 10: 85-88, 2002.
APA
Rebuffat, P., Forneris, M.L., Macchi, C., Malendowicz, L.K., Trejter, M., & Nussdorfer, G.G. (2002). Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands. International Journal of Molecular Medicine, 10, 85-88. https://doi.org/10.3892/ijmm.10.1.85
MLA
Rebuffat, P., Forneris, M. L., Macchi, C., Malendowicz, L. K., Trejter, M., Nussdorfer, G. G."Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands". International Journal of Molecular Medicine 10.1 (2002): 85-88.
Chicago
Rebuffat, P., Forneris, M. L., Macchi, C., Malendowicz, L. K., Trejter, M., Nussdorfer, G. G."Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands". International Journal of Molecular Medicine 10, no. 1 (2002): 85-88. https://doi.org/10.3892/ijmm.10.1.85
Copy and paste a formatted citation
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Spandidos Publications style
Rebuffat P, Forneris ML, Macchi C, Malendowicz LK, Trejter M and Nussdorfer GG: Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands. Int J Mol Med 10: 85-88, 2002.
APA
Rebuffat, P., Forneris, M.L., Macchi, C., Malendowicz, L.K., Trejter, M., & Nussdorfer, G.G. (2002). Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands. International Journal of Molecular Medicine, 10, 85-88. https://doi.org/10.3892/ijmm.10.1.85
MLA
Rebuffat, P., Forneris, M. L., Macchi, C., Malendowicz, L. K., Trejter, M., Nussdorfer, G. G."Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands". International Journal of Molecular Medicine 10.1 (2002): 85-88.
Chicago
Rebuffat, P., Forneris, M. L., Macchi, C., Malendowicz, L. K., Trejter, M., Nussdorfer, G. G."Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: Evidences of upregulation of ADM system in immature glands". International Journal of Molecular Medicine 10, no. 1 (2002): 85-88. https://doi.org/10.3892/ijmm.10.1.85
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