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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2002 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 10 Issue 3

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Article

Gain of Xq detected by comparative genomic hybridization in elastofibroma

  • Authors:
    • J. Nishio
    • H. Iwasaki
    • Y. Ohjimi
    • M. Ishiguro
    • T. Koga
    • T. Isayama
    • M. Naito
    • M. Kikuchi

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan. nishio@minf.med.fukuoka-u.ac.jp
  • Pages: 277-280
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijmm.10.3.277
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Abstract

Elastofibroma is a rare, benign, slow-growing degenerative pseudotumor that typically occurs in the subscapular region and has been considered a peculiar fibroblastic proliferation with accumulation of abnormal elastic fibers. Very little is known about the cytogenetic and molecular genetic changes in elastofibroma. In the present study, we analyzed DNA copy number changes in 27 elastofibromas by comparative genomic hybridization. DNA was extracted from 22 archival paraffin-embedded tumor tissues and from 5 fresh frozen samples. Nine (33%) of the 27 cases exhibited DNA copy number changes involving one or two chromosomes, whereas the remaining 18 cases exhibited no DNA copy number changes. The majority of the changes were gains (8 cases), whereas 2 cases showed losses. The most common recurrent gains were at chromosomal locations Xq12-q22 (6 cases) and 19 (2 cases). High-level amplifications and recurrent losses were not observed. There was no correlation between DNA copy number changes and the pseudotumor size. The present study has identified a chromosomal region that may contain genes involved in the development of at least some elastofibromas.

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Copy and paste a formatted citation
Spandidos Publications style
Nishio J, Iwasaki H, Ohjimi Y, Ishiguro M, Koga T, Isayama T, Naito M and Kikuchi M: Gain of Xq detected by comparative genomic hybridization in elastofibroma. Int J Mol Med 10: 277-280, 2002.
APA
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T. ... Kikuchi, M. (2002). Gain of Xq detected by comparative genomic hybridization in elastofibroma. International Journal of Molecular Medicine, 10, 277-280. https://doi.org/10.3892/ijmm.10.3.277
MLA
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T., Naito, M., Kikuchi, M."Gain of Xq detected by comparative genomic hybridization in elastofibroma". International Journal of Molecular Medicine 10.3 (2002): 277-280.
Chicago
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T., Naito, M., Kikuchi, M."Gain of Xq detected by comparative genomic hybridization in elastofibroma". International Journal of Molecular Medicine 10, no. 3 (2002): 277-280. https://doi.org/10.3892/ijmm.10.3.277
Copy and paste a formatted citation
x
Spandidos Publications style
Nishio J, Iwasaki H, Ohjimi Y, Ishiguro M, Koga T, Isayama T, Naito M and Kikuchi M: Gain of Xq detected by comparative genomic hybridization in elastofibroma. Int J Mol Med 10: 277-280, 2002.
APA
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T. ... Kikuchi, M. (2002). Gain of Xq detected by comparative genomic hybridization in elastofibroma. International Journal of Molecular Medicine, 10, 277-280. https://doi.org/10.3892/ijmm.10.3.277
MLA
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T., Naito, M., Kikuchi, M."Gain of Xq detected by comparative genomic hybridization in elastofibroma". International Journal of Molecular Medicine 10.3 (2002): 277-280.
Chicago
Nishio, J., Iwasaki, H., Ohjimi, Y., Ishiguro, M., Koga, T., Isayama, T., Naito, M., Kikuchi, M."Gain of Xq detected by comparative genomic hybridization in elastofibroma". International Journal of Molecular Medicine 10, no. 3 (2002): 277-280. https://doi.org/10.3892/ijmm.10.3.277
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