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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2002 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro

  • Authors:
    • Maria Teresa Conconi
    • Mara Tommasini
    • Silvia Baiguera
    • Paolo De Coppi
    • Pier Paolo Parnigotto
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Sciences, University of Padua, I-35121 Padua, Italy
  • Pages: 451-456
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijmm.10.4.451
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Abstract

Prostaglandins E (PGEs) are abundantly produced in the skeletal tissue, the turnover of which they can modulate acting on both bone deposition and resorption. We compared the effects of PGE1 and PGE2 on the growth and differentiation of rat bone-marrow osteoblast-like cells cultured in vitro. Both PGEs stimulated cultured cell growth, PGE2 being more effective than PGE1. PGE1 inhibited and PGE2 enhanced alkaline phosphatase activity. Both PGEs markedly raised osteocalcin synthesis, without apparently affecting collagenase-digestible protein production. Scanning electron microscopy showed that untreated cultured osteoblast-like cells were arranged in clusters and displayed a polygonal shape. PGE1 did not alter cell morphology, while PGE2 provoked elongation of cultured cells and sprouting of slend cytoplasmic processes. Morphometric analysis indicated that PGE1 decreased and PGE2 increased cultured-cell dimensions. Collectively, these findings allow us to conclude that PGE1 and PGE2, although being both able to enhance proliferation of osteoblast-like cells cultured in vitro, exert divergent effects on their differentiation. PGE1 seems to slow-down osteoblast maturation, while PGE2 appears to stimulate osteoblast differentiation to mature osteocytes.

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Copy and paste a formatted citation
Spandidos Publications style
Conconi MT, Tommasini M, Baiguera S, De Coppi P, Parnigotto PP and Nussdorfer GG: Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro. Int J Mol Med 10: 451-456, 2002.
APA
Conconi, M.T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P.P., & Nussdorfer, G.G. (2002). Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro. International Journal of Molecular Medicine, 10, 451-456. https://doi.org/10.3892/ijmm.10.4.451
MLA
Conconi, M. T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P. P., Nussdorfer, G. G."Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro". International Journal of Molecular Medicine 10.4 (2002): 451-456.
Chicago
Conconi, M. T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P. P., Nussdorfer, G. G."Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro". International Journal of Molecular Medicine 10, no. 4 (2002): 451-456. https://doi.org/10.3892/ijmm.10.4.451
Copy and paste a formatted citation
x
Spandidos Publications style
Conconi MT, Tommasini M, Baiguera S, De Coppi P, Parnigotto PP and Nussdorfer GG: Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro. Int J Mol Med 10: 451-456, 2002.
APA
Conconi, M.T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P.P., & Nussdorfer, G.G. (2002). Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro. International Journal of Molecular Medicine, 10, 451-456. https://doi.org/10.3892/ijmm.10.4.451
MLA
Conconi, M. T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P. P., Nussdorfer, G. G."Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro". International Journal of Molecular Medicine 10.4 (2002): 451-456.
Chicago
Conconi, M. T., Tommasini, M., Baiguera, S., De Coppi, P., Parnigotto, P. P., Nussdorfer, G. G."Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro". International Journal of Molecular Medicine 10, no. 4 (2002): 451-456. https://doi.org/10.3892/ijmm.10.4.451
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