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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2002 Volume 10 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

RNA-mediated gene regulation system: Now and the future (Review)

James Q. Yin, Yinsheng Wan
Pages: 355-365
Published online on: 01 October 2002

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Review

Hirschsprung, RET-SOX and beyond: The challenge of examining non-mendelian traits (Review)

C. M. Pusch, M. M. Sasiadek, N. Blin
Pages: 367-370
Published online on: 01 October 2002

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Article

Molecular analysis of TGF-βs and their receptors in human keratinocyte cell lines of different biological behaviour

Beatrice E. Bachmeier, Isabell Ruoss, Hjalmar G. Hagedorn, Andreas G. Nerlich
Pages: 371-376
Published online on: 01 October 2002

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Article

Role of endogenous regucalcin in bone metabolism: Bone loss is induced in regucalcin transgenic rats

Masayoshi Yamaguchi, H. Misawa, S. Uchiyama, Y. Morooka, Y. Tsurusaki
Pages: 377-383
Published online on: 01 October 2002

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Article

Enhanced ability of the progenipoietin-1 to suppress apoptosis in human hematopoietic cells

Oussama A. Saleh, William L. Blalock, Carla Burrows, Linda S. Steelman, Parul D. Doshi, John P. McKearn, James A. McCubrey
Pages: 385-394
Published online on: 01 October 2002

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Article

Codon 45 of the β-catenin gene, a specific mutational target site of Wilms' tumor

T. Kusafuka, J. Miao, S. Kuroda, Y. Udatsu, A. Yoneda
Pages: 395-399
Published online on: 01 October 2002

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Article

Evidence for an autocrine-paracrine role of adrenomedullin in the cultured rat adrenal zona glomerulosa cells

Paola G. Andreis, G. Albertin, Maria Teresa Conconi, G. Carraro, L. K. Malendowicz, Agnieszka Ziolkowska, Gastone G. Nussdorfer
Pages: 401-405
Published online on: 01 October 2002

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Article

Effects of blue-light-exposure on growth of extracorporeally circulated leukemic cells in rats with leukemia induced by 1-ethyl-1-nitrosourea

Masayuki Ohara, Yuzo Kawashima, Hiromitsu Watanabe, Shunichi Kitajima
Pages: 407-411
Published online on: 01 October 2002

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Review

Communication between animal cells and the plant foods they ingest: Phyto-zooidal dependencies and signaling (Review)

George B. Stefano, Jeff Miller
Pages: 413-421
Published online on: 01 October 2002

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Article

Angiopoietin-1 and vascular endothelial growth factor expression in human esophageal cancer

Junko Nagata, Hiroshi Kijima, Hiroyuki Hatanaka, Tetsuji Tokunaga, Junichiro Kamochi, Yoshiyuki Abe, Atsushi Takagi, Tetsuya Mine, Hitoshi Yamazaki, Masato Nakamura, Yoshito Ueyama
Pages: 423-426
Published online on: 01 October 2002

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Article

Efficacy of chemopreventive agents for growth inhibition of Apc [+/-] 1638NCOL colonic epithelial cells

Meena Katdare, Levy Kopelovich, Nitin Telang
Pages: 427-432
Published online on: 01 October 2002

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Article

Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells

Lucia Malaguarnera, Maria Rosaria Pilastro, Shuo Quan, Maivel H. Ghattas, Liming Yang, Alexandre V. Mezentsev, Taketoshi Kushida, Nader G. Abraham, Attalah Kappas
Pages: 433-440
Published online on: 01 October 2002

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Article

Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS

Benedetta Bussolati, Salvatore David, Vincenzo Cambi, Peter S. Tobias, Giovanni Camussi
Pages: 441-449
Published online on: 01 October 2002

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Article

Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro

Maria Teresa Conconi, Mara Tommasini, Silvia Baiguera, Paolo De Coppi, Pier Paolo Parnigotto, Gastone G. Nussdorfer
Pages: 451-456
Published online on: 01 October 2002

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Article

Significance of brain natriuretic peptides in patients on continuous ambulatory peritoneal dialysis

Tatuya Nakatani, Toshihide Naganuma, Chikayoshi Masuda, Junji Uchida, Takeshi Sugimura, Kazunobu Sugimura
Pages: 457-461
Published online on: 01 October 2002

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Article

Induction of cell arrest by transfection of macrophage migration inhibitory factor antisense plasmid

Y. Yasuda, K. Kasuya, J. Nishihira, Y. Sasaki, A. Tsuchida, T. Aoki, Y. Koyanagi
Pages: 463-467
Published online on: 01 October 2002

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Article

Response of peripheral blood mononuclear cells in hemodialyzed patients against endotoxin and muramyldipeptide

Tatsuya Nakatani, Kenji Tsuchida, Kazunobu Sugimura, Rikio Yoshimura, Yoshiaki Takemoto
Pages: 469-472
Published online on: 01 October 2002

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Article

The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide

Renate V. Bardeleben, Torsten Dunkern, Bernd Kaina, Gerhard Fritz
Pages: 473-479
Published online on: 01 October 2002

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Article

Influence of allergen-specific immunotherapy on IL-4-dependent IL-12 production by monocytes

Katarzyna Grzela, Tomasz Grzela, Maciej Lazarczyk, Grazyna Korczak-Kowalska, Piotr Wierzbicki, Anna Zawadzka-Krajewska, Jaroslaw Jozwiak, Piotr Skopinski
Pages: 481-484
Published online on: 01 October 2002

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Article

Direct hemoperfusion by using Lixelle® column for the treatment of systemic inflammatory response syndrome

Kenji Tsuchida, Yoshiaki Takemoto, Kazunobu Sugimura, Rikio Yoshimura, Tatsuya Nakatani
Pages: 485-488
Published online on: 01 October 2002

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Article

Alteration in expression of polyamine and glucose-related enzyme mRNA after small bowel resection in the rat residual ileum

Tomoyuki Tsujikawa, Tetsuya Fukunaga, Akihiko Itoh, Jin Satoh, Takashi Yasuoka, Masaya Sasaki, Yoshihide Fujiyama, Tadao Bamba
Pages: 489-492
Published online on: 01 October 2002

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Review

Myristoyl-CoA:protein N-myristoyltransferase: A novel molecular approach for cancer therapy (Review)

Ponniah Selvakumar, Mohammed Khysar Pasha, Lakshmikuttyamma Ashakumary, Jonathan R. Dimmock, Rajendra K. Sharma
Pages: 493-500
Published online on: 01 October 2002

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Article

Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway

Jian-Jun Liu, Ake Nilsson, Stina Oredsson, Vladimir Badmaev, Rui-Dong Duan
Pages: 501-505
Published online on: 01 October 2002

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Article

Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid

Hiroyuki Kirikoshi, Masaru Katoh
Pages: 507-511
Published online on: 01 October 2002

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Article

An HPLC method for the measurement of 5-fluorouracil in human plasma with a low detection limit and a high extraction yield

Mark Adel Nassim, Farshad H. Shirazi, Christine M. Cripps, Shereeni Veerasinghan, Matshela J. Molepo, Mihail Obrocea, Diedre Redmond, Susan Bates, Diane Fry, David J. Stewart, Rakesh Goel
Pages: 513-516
Published online on: 01 October 2002

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Article

Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus

H. Ben-Hur, G. Kossoy, N. Kossoy, I. Zusman
Pages: 517-521
Published online on: 01 October 2002

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Article

Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice

Akihiro Asakawa, Akio Inui, Kyoko Goto, Hideki Yuzuriha, Yoshiyuki Takimoto, Toshio Inui, Goro Katsuura, Masayuki A. Fujino, Michael M. Meguid, Masato Kasuga
Pages: 523-525
Published online on: 01 October 2002

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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