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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2002 Volume 10 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus

  • Authors:
    • H. Ben-Hur
    • G. Kossoy
    • N. Kossoy
    • I. Zusman

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Medicine affiliated to the Institute of Pathology, Assaf Harofeh Medical Center, Tserifin, Israel
  • Pages: 517-521
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijmm.10.4.517
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Abstract

We showed in a previous study that soluble low-molecular-mass tumor-associated antigens (sTAA) promote the anti-tumor effect of the anticancer drug cyclophosphamide (CPA) on rat mammary carcinogenesis. In this report, we analyzed the possible mechanism underlying this phenomenon. Studies were performed on the bone marrow and thymus from the following groups of rats: i) control rats, ii) rats treated with sTAA, iii) rats treated with CPA, iv) rats treated with CPA and sTAA. The cellular content of the bone marrow and thymus (CD4+ and CD8+ lymphocytes) was analyzed morphometrically and immunohistochemically. In the bone marrow, CPA caused significant substitution of cellular components with fatty tissue whereas sTAA repaired this process. We found that CPA affects mainly the process of myelogenesis whereas sTAA protect the production of lymphocytes. In the thymus, CPA alone or in combination with sTAA repaired the inhibition effect of DMBA on synthesis of CD4+ and CD8+ thymocytes. sTAA further increased the amount of CD8+ T lymphocytes in the medulla of the thymus. Data in the literature as well as the findings presented here demonstrate that the tested treatment, including vaccination with sTAA, actively promotes the generation of the host's antitumor immune response.

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Copy and paste a formatted citation
Spandidos Publications style
Ben-Hur H, Kossoy G, Kossoy N and Zusman I: Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. Int J Mol Med 10: 517-521, 2002.
APA
Ben-Hur, H., Kossoy, G., Kossoy, N., & Zusman, I. (2002). Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. International Journal of Molecular Medicine, 10, 517-521. https://doi.org/10.3892/ijmm.10.4.517
MLA
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10.4 (2002): 517-521.
Chicago
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10, no. 4 (2002): 517-521. https://doi.org/10.3892/ijmm.10.4.517
Copy and paste a formatted citation
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Spandidos Publications style
Ben-Hur H, Kossoy G, Kossoy N and Zusman I: Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. Int J Mol Med 10: 517-521, 2002.
APA
Ben-Hur, H., Kossoy, G., Kossoy, N., & Zusman, I. (2002). Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus. International Journal of Molecular Medicine, 10, 517-521. https://doi.org/10.3892/ijmm.10.4.517
MLA
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10.4 (2002): 517-521.
Chicago
Ben-Hur, H., Kossoy, G., Kossoy, N., Zusman, I."Response of the immune system of mammary tumor-bearing rats to cyclophosphamide and soluble low-molecular-mass tumor-associated antigens: The bone marrow and thymus". International Journal of Molecular Medicine 10, no. 4 (2002): 517-521. https://doi.org/10.3892/ijmm.10.4.517
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