Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice

  • Authors:
    • Akihiro Asakawa
    • Akio Inui
    • Kyoko Goto
    • Hideki Yuzuriha
    • Yoshiyuki Takimoto
    • Toshio Inui
    • Goro Katsuura
    • Masayuki A. Fujino
    • Michael M. Meguid
    • Masato Kasuga
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijmm.10.4.523
  • Pages: 523-525
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Abstract

Neuropeptides in the hypothalamus play a pivotal role in the regulation of energy balance. Agouti-related protein (AGRP), orexin and melanin-concentrating hormone (MCH) have been identified in the hypothalamus as orexigenic peptides. This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption. Oxygen consumption was determined by an O2/CO2 metabolism measuring system at 22°C. Mice were kept unrestrained in the chamber without food or water during the light cycle, and the oxygen consumption was measured for 2 h after intra-cerebroventricular (ICV) administration. ICV administered AGRP (1 nmol/mouse) significantly decreased oxygen consumption compared to ACSF-treated controls. Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls. These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight.

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October 2002
Volume 10 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Asakawa A, Inui A, Goto K, Yuzuriha H, Takimoto Y, Inui T, Katsuura G, Fujino MA, Meguid MM, Kasuga M, Kasuga M, et al: Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int J Mol Med 10: 523-525, 2002
APA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T. ... Kasuga, M. (2002). Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. International Journal of Molecular Medicine, 10, 523-525. https://doi.org/10.3892/ijmm.10.4.523
MLA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10.4 (2002): 523-525.
Chicago
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10, no. 4 (2002): 523-525. https://doi.org/10.3892/ijmm.10.4.523