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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2002 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2002 Volume 10 Issue 4

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Article

Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice

  • Authors:
    • Akihiro Asakawa
    • Akio Inui
    • Kyoko Goto
    • Hideki Yuzuriha
    • Yoshiyuki Takimoto
    • Toshio Inui
    • Goro Katsuura
    • Masayuki A. Fujino
    • Michael M. Meguid
    • Masato Kasuga

  • View Affiliations / Copyright

    Affiliations: Division of Diabetes, Digestive and kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
  • Pages: 523-525
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijmm.10.4.523
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Abstract

Neuropeptides in the hypothalamus play a pivotal role in the regulation of energy balance. Agouti-related protein (AGRP), orexin and melanin-concentrating hormone (MCH) have been identified in the hypothalamus as orexigenic peptides. This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption. Oxygen consumption was determined by an O2/CO2 metabolism measuring system at 22°C. Mice were kept unrestrained in the chamber without food or water during the light cycle, and the oxygen consumption was measured for 2 h after intra-cerebroventricular (ICV) administration. ICV administered AGRP (1 nmol/mouse) significantly decreased oxygen consumption compared to ACSF-treated controls. Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls. These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight.

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Copy and paste a formatted citation
Spandidos Publications style
Asakawa A, Inui A, Goto K, Yuzuriha H, Takimoto Y, Inui T, Katsuura G, Fujino MA, Meguid MM, Kasuga M, Kasuga M, et al: Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int J Mol Med 10: 523-525, 2002.
APA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T. ... Kasuga, M. (2002). Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. International Journal of Molecular Medicine, 10, 523-525. https://doi.org/10.3892/ijmm.10.4.523
MLA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10.4 (2002): 523-525.
Chicago
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10, no. 4 (2002): 523-525. https://doi.org/10.3892/ijmm.10.4.523
Copy and paste a formatted citation
x
Spandidos Publications style
Asakawa A, Inui A, Goto K, Yuzuriha H, Takimoto Y, Inui T, Katsuura G, Fujino MA, Meguid MM, Kasuga M, Kasuga M, et al: Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int J Mol Med 10: 523-525, 2002.
APA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T. ... Kasuga, M. (2002). Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. International Journal of Molecular Medicine, 10, 523-525. https://doi.org/10.3892/ijmm.10.4.523
MLA
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10.4 (2002): 523-525.
Chicago
Asakawa, A., Inui, A., Goto, K., Yuzuriha, H., Takimoto, Y., Inui, T., Katsuura, G., Fujino, M. A., Meguid, M. M., Kasuga, M."Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice". International Journal of Molecular Medicine 10, no. 4 (2002): 523-525. https://doi.org/10.3892/ijmm.10.4.523
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